VUF-5681
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Preferred IUPAC name 4-[3-(1H-Imidazol-5-yl)propyl]piperidine | |
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Chemical formula | C11H19N3 |
Molar mass | 193.288 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). ![]() ![]() ![]() Infobox references |
Chemical compound
VUF-5681 is a potent and selective histamine antagonist which binds selectively to the H3 subtype.[1] However while VUF-5681 blocks the activity of more potent H3 agonists, recent studies suggest that it may have some weak partial agonist activity when administered by itself.[2]
References
- ^ Moreno-Delgado D, Torrent A, Gómez-Ramírez J, de Esch I, Blanco I, Ortiz J (September 2006). "Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway". Neuropharmacology. 51 (3): 517–23. doi:10.1016/j.neuropharm.2006.04.010. PMID 16769092. S2CID 25209099.
- ^ Baker JG (June 2008). "Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells". BMC Pharmacology. 8: 9. doi:10.1186/1471-2210-8-9. PMC 2430196. PMID 18538007.
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Histamine receptor modulators
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- See also
- Receptor/signaling modulators
- Monoamine metabolism modulators
- Monoamine reuptake inhibitors
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