VVD-118313
Chemical compound
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Formula | C19H22Cl2N2O3S |
Molar mass | 429.36 g·mol−1 |
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VVD-118313 is a chemical compound which acts as a potent and selective negative allosteric modulator of JAK1, and was developed for research into the treatment of inflammatory diseases, especially chronic inflammation involved in the development of cancer.[1][2][3][4]
See also
- Deucravacitinib
References
- ^ Kavanagh ME, Horning BD, Khattri R, Roy N, Lu JP, Whitby LR, et al. (December 2022). "Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine". Nature Chemical Biology. 18 (12): 1388–1398. doi:10.1038/s41589-022-01098-0. PMC 7614775. PMID 36097295.
- ^ Silvennoinen O, Haikarainen T, Virtanen A (December 2022). "Aiming for the pocket". Nature Chemical Biology. 18 (12): 1296–1297. doi:10.1038/s41589-022-01120-5. PMID 36097296.
- ^ Caveney NA, Saxton RA, Waghray D, Glassman CR, Tsutsumi N, Hubbard SR, et al. (March 2023). "Structural basis of Janus kinase trans-activation". Cell Reports. 42 (3): 112201. doi:10.1016/j.celrep.2023.112201. PMC 10180219. PMID 36867534.
- ^ Henry SP, Jorgensen WL (August 2023). "Progress on the Pharmacological Targeting of Janus Pseudokinases". Journal of Medicinal Chemistry. 66 (16): 10959–10990. doi:10.1021/acs.jmedchem.3c00926. PMID 37578217.
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