Vesicle-associated membrane protein
Protein family
Synaptobrevin | |||||||||
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![]() Three different views of the high resolution structure of a truncated neuronal SNARE complex. Legend: synaptobrevin-2 (red), Syntaxin-1 (pink), SNAP-25 (purple). | |||||||||
Identifiers | |||||||||
Symbol | Synaptobrevin | ||||||||
Pfam | PF00957 | ||||||||
InterPro | IPR016444 | ||||||||
PROSITE | PDOC00368 | ||||||||
SCOP2 | 1sfc / SCOPe / SUPFAM | ||||||||
OPM superfamily | 197 | ||||||||
OPM protein | 4wy4 | ||||||||
Membranome | 198 | ||||||||
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![](http://upload.wikimedia.org/wikipedia/commons/thumb/f/fd/Hypothetic_models_of_VAMP2_conformations_and_engagement_in_SNARE_complex_assembly_for_neurotransmitter_release.pdf/page1-220px-Hypothetic_models_of_VAMP2_conformations_and_engagement_in_SNARE_complex_assembly_for_neurotransmitter_release.pdf.jpg)
Vesicle associated membrane proteins (VAMPs) are a family of SNARE proteins with similar structure, and are mostly involved in vesicle fusion.
- VAMP1 and VAMP2 proteins known as synaptobrevins are expressed in brain and are constituents of the synaptic vesicles, where they participate in neurotransmitter release.
- VAMP3 (known as cellubrevin) is ubiquitously expressed and participates in regulated and constitutive exocytosis as a constituent of secretory granules and secretory vesicles.
- VAMP5 and VAMP7 participate in constitutive exocytosis.
- VAMP5 is a constituent of secretory vesicles, myotubes and tubulovesicular structures.
- VAMP7 is found both in secretory granules and endosomes.
- VAMP8 (known as endobrevin) participates in endocytosis and is found in early endosomes. VAMP8 also participates the regulated exocytosis in pancreatic acinar cells.
- VAMP4 is involved in transport from the Golgi.[1]
References
- ^ Steegmaier M, Klumperman J, Foletti DL, Yoo JS, Scheller RH (1999). "Vesicle-associated membrane protein 4 is implicated in trans-Golgi network vesicle trafficking". Mol. Biol. Cell. 10 (6): 1957–72. doi:10.1091/mbc.10.6.1957. PMC 25394. PMID 10359608.
External links
- Vesicle-Associated+Membrane+Protein+1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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see also other cell membrane protein disorders
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