ZMYM2

Protein-coding gene in the species Homo sapiens

ZMYM2

Identifiers

Aliases

ZMYM2, FIM, MYM, RAMP, SCLL, ZNF198, zinc finger MYM-type containing 2, NECRC

External IDs

OMIM: 602221; MGI: 1923257; HomoloGene: 12631; GeneCards: ZMYM2; OMA:ZMYM2 - orthologs

Gene location (Human)

Chr.	Chromosome 13 (human)^[1]

Band	13q12.11	Start	19,958,677 bp^[1]
Band	13q12.11	End	20,091,829 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 14 (mouse)^[2]

Band	14\|14 C3	Start	57,124,110 bp^[2]
Band	14\|14 C3	End	57,200,158 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

sperm

oocyte

secondary oocyte

ganglionic eminence

buccal mucosa cell

right testis

Achilles tendon

left testis

testicle

ventricular zone

Top expressed in

hand

genital tubercle

tail of embryo

spermatocyte

ganglionic eminence

ventricular zone

medial ganglionic eminence

epiblast

neural layer of retina

abdominal wall

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	zinc ion binding metal ion binding ubiquitin conjugating enzyme binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding protein tyrosine kinase activity protein binding
Cellular component	cytosol nucleus PML body cytoplasm nucleoplasm
Biological process	regulation of transcription, DNA-templated transcription, DNA-templated cytoskeleton organization regulation of cell morphogenesis multicellular organism development peptidyl-tyrosine phosphorylation regulation of transcription by RNA polymerase II biological process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


7750


76007

Ensembl


ENSG00000121741


ENSMUSG00000021945

UniProt


Q9UBW7


Q9CU65

RefSeq (mRNA)

NM_001190964 NM_001190965 NM_003453 NM_197968 NM_001353157
NM_001353159 NM_001353161 NM_001353162 NM_001353163 NM_001353164 NM_001353165


NM_029498 NM_177627 NM_001360643

RefSeq (protein)

NP_001177893 NP_001177894 NP_003444 NP_932072 NP_001340086
NP_001340088 NP_001340090 NP_001340091 NP_001340092 NP_001340093 NP_001340094


NP_083774 NP_001347572 NP_808295

Location (UCSC)

Chr 13: 19.96 – 20.09 Mb

Chr 14: 57.12 – 57.2 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Zinc finger MYM-type protein 2 is a protein that in humans is encoded by the ZMYM2 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000121741 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021945 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Smedley D, Hamoudi R, Clark J, Warren W, Abdul-Rauf M, Somers G, Venter D, Fagan K, Cooper C, Shipley J (April 1998). "The t(8;13)(p11;q11-12) rearrangement associated with an atypical myeloproliferative disorder fuses the fibroblast growth factor receptor 1 gene to a novel gene RAMP". Human Molecular Genetics. 7 (4): 637–42. doi:10.1093/hmg/7.4.637. PMID 9499416.
^ Xiao S, Nalabolu SR, Aster JC, Ma J, Abruzzo L, Jaffe ES, Stone R, Weissman SM, Hudson TJ, Fletcher JA (January 1998). "FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome". Nature Genetics. 18 (1): 84–7. doi:10.1038/ng0198-84. PMID 9425908. S2CID 826758.
^ "Entrez Gene: ZMYM2 zinc finger, MYM-type 2".

Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Popovici C, Adélaïde J, Ollendorff V, Chaffanet M, Guasch G, Jacrot M, Leroux D, Birnbaum D, Pébusque MJ (May 1998). "Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13)". Proceedings of the National Academy of Sciences of the United States of America. 95 (10): 5712–7. doi:10.1073/pnas.95.10.5712. PMC 20444. PMID 9576949.
Still IH, Cowell JK (August 1998). "The t(8;13) atypical myeloproliferative disorder: further analysis of the ZNF198 gene and lack of evidence for multiple genes disrupted on chromosome 13". Blood. 92 (4): 1456–8. doi:10.1182/blood.V92.4.1456.splL3_1456_1458. PMID 9694738.
Reiter A, Sohal J, Kulkarni S, Chase A, Macdonald DH, Aguiar RC, Gonçalves C, Hernandez JM, Jennings BA, Goldman JM, Cross NC (September 1998). "Consistent fusion of ZNF198 to the fibroblast growth factor receptor-1 in the t(8;13)(p11;q12) myeloproliferative syndrome". Blood. 92 (5): 1735–42. doi:10.1182/blood.V92.5.1735. PMID 9716603.
Kulkarni S, Reiter A, Smedley D, Goldman JM, Cross NC (January 1999). "The genomic structure of ZNF198 and location of breakpoints in the t(8;13) myeloproliferative syndrome". Genomics. 55 (1): 118–21. doi:10.1006/geno.1998.5634. PMID 9889006.
Ollendorff V, Guasch G, Isnardon D, Galindo R, Birnbaum D, Pébusque MJ (September 1999). "Characterization of FIM-FGFR1, the fusion product of the myeloproliferative disorder-associated t(8;13) translocation". The Journal of Biological Chemistry. 274 (38): 26922–30. doi:10.1074/jbc.274.38.26922. PMID 10480903.
Matsumoto K, Morita K, Takada S, Sakura T, Shiozaki H, Murakami H, Miyawaki S (December 1999). "A chronic myelogenous leukemia-like myeloproliferative disorder accompanied by T-cell lymphoblastic lymphoma with chromosome translocation t(8;13)(p11;q12): a Japanese case". International Journal of Hematology. 70 (4): 278–82. PMID 10643154.
Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (February 2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". The Journal of Biological Chemistry. 278 (9): 7234–9. doi:10.1074/jbc.M208992200. PMID 12493763.
Baumann H, Kunapuli P, Tracy E, Cowell JK (May 2003). "The oncogenic fusion protein-tyrosine kinase ZNF198/fibroblast growth factor receptor-1 has signaling function comparable with interleukin-6 cytokine receptors". The Journal of Biological Chemistry. 278 (18): 16198–208. doi:10.1074/jbc.M300018200. PMID 12594223.
Kunapuli P, Somerville R, Still IH, Cowell JK (May 2003). "ZNF198 protein, involved in rearrangement in myeloproliferative disease, forms complexes with the DNA repair-associated HHR6A/6B and RAD18 proteins". Oncogene. 22 (22): 3417–23. doi:10.1038/sj.onc.1206408. PMID 12776193. S2CID 21536204.
Warner DR, Roberts EA, Greene RM, Pisano MM (December 2003). "Identification of novel Smad binding proteins". Biochemical and Biophysical Research Communications. 312 (4): 1185–90. doi:10.1016/j.bbrc.2003.11.049. PMID 14651998.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (July 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.