Ouabaina
Ouabaina | |
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Formula kimikoa | C29H44O12 |
SMILES kanonikoa | 2D eredua |
SMILES isomerikoa | C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@H]2C[C@H]([C@@]3([C@@H]4[C@@H](CC[C@@]3(C2)O)[C@]5(CC[C@@H]([C@]5(C[C@H]4O)C)C6=CC(=O)OC6)O)CO)O)O)O)O |
MolView | 3D eredua |
Mota | [[3-[(1R,3S,5S,8R,9S,10R,11R,13R,14S,17R)-1,5,11,14-tetrahydroxy-10-(hydroxymethyl)-13-methyl-3-[(2R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2H-furan-5-one|3-[(1R,3S,5S,8R,9S,10R,11R,13R,14S,17R)-1,5,11,14-tetrahydroxy-10-(hydroxymethyl)-13-methyl-3-[(2R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2H-furan-5-one]] (en) ![]() ![]() |
Estereoisomeroa | [[3-[(1R,3S,5S,8R,9S,10R,11R,13R,14S,17R)-1,5,11,14-tetrahydroxy-10-(hydroxymethyl)-13-methyl-3-[(2R,3R,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2H-furan-5-one|3-[(1R,3S,5S,8R,9S,10R,11R,13R,14S,17R)-1,5,11,14-tetrahydroxy-10-(hydroxymethyl)-13-methyl-3-[(2R,3R,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2H-furan-5-one]] (en) ![]() |
Masa molekularra | 584,283 Da |
Erabilera | |
Rola | Entzimen inhibitzaile eta cardiotonic (en) ![]() |
Identifikatzaileak | |
InChlKey | LPMXVESGRSUGHW-HBYQJFLCSA-N |
CAS zenbakia | 630-60-4 |
ChemSpider | 388599 |
PubChem | 439501 |
Reaxys | 101712 |
Gmelin | 472805 |
ChEMBL | CHEMBL222863 |
ZVG | 510358 |
EC zenbakia | 211-139-3 |
ECHA | 100.010.128 |
MeSH | D010042 |
RxNorm | 7762 |
Human Metabolome Database | HMDB0015224 |
KNApSAcK | C00003633 |
UNII | 5ACL011P69 |
KEGG | C01443 |
PDB Ligand | OBN |
Ouabaina (wabaina gisa ahoskatua; somalieraz: waabaayo, "gezi pozoia") edo g-estrofantina landareetatik ateratzen den sustantzia toxiko bat da. Afrikako ekialdean geziak pozoitzeko erabili da tradizionalki, bai ehizan zein gerran. Glukosido kardiotoxiko bat da, eta dosi txikietan hipotentsioa eta arritmiak tratatzeko erabil daiteke. Sodio-potasio ponpa inhibitzen du. Hala ere, intsektu belarjale espezie batzuek sodio-potasio ponparen alfa azpiunitatean aldaketak izan dituzte aminoazido mailan, toxina honi erresistentzia erakutsiz[1].
Acokanthera generoan eta Strophanthus gratus espeziearen sustrai, enbor, hosto eta hazietan aurki daiteke[2].
Erreferentziak
- ↑ (Ingelesez) Dobler, Susanne; Dalla, Safaa; Wagschal, Vera; Agrawal, Anurag A.. (2012-08-07). «Community-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in the Na,K-ATPase» Proceedings of the National Academy of Sciences 109 (32): 13040–13045. doi:10.1073/pnas.1202111109. ISSN 0027-8424. PMID 22826239. PMC PMC3420205. (Noiz kontsultatua: 2020-08-29).
- ↑ Miller, James S.. (1999-07). «African Ethnobotany: Poisons and Drugs Hans Dieter Neuwinger (St. Leon-Rot, Germany). Chapman and Hall, Weinheim, Germany. 1999. xviii + 941 pp. 19 × 27 cm. $119.95. ISBN 3-8876-30661.» Journal of Natural Products 62 (7): 1077–1078. doi:10.1021/np990752a. ISSN 0163-3864. (Noiz kontsultatua: 2020-08-29).
Kanpo estekak
Datuak: Q285911
Multimedia: Ouabain / Q285911