IFNA14

Interferon, alpha 14

Tanda pengenal

Simbol

IFNA14; IFN-alphaH; LEIF2H

ID eksternal

OMIM: 147579 HomoloGene: 122139 GeneCards: IFNA14 Gene

Gene Ontology
Fungsi molekul	• cytokine activity • cytokine receptor binding
Komponen sel	• extracellular region • extracellular space
Proses biologis	• blood coagulation • cytokine-mediated signaling pathway • innate immune response • defense response to virus • type I interferon-mediated signaling pathway • regulation of type I interferon-mediated signaling pathway
Sumber: Amigo / QuickGO

Orthologs

Spesies

Manusia

Tikus

Entrez

3448

n/a

Ensembl

ENSG00000228083

n/a

UniProt

P01570

n/a

RefSeq (mRNA)

NM_002172

n/a

RefSeq (protein)

NP_002163

n/a

Lokasi (UCSC)

Chr 9:
21.24 – 21.24 Mb

n/a

PubMed

[1]

n/a

Interferon alpha-14 adalah protein yang pada manusia disandikan oleh gen IFNA14.^[1]^[2]

Referensi

^ Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics. 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID 1385305. Parameter |month= yang tidak diketahui akan diabaikan (bantuan)Pemeliharaan CS1: Banyak nama: authors list (link)
^ "Entrez Gene: IFNA14 interferon, alpha 14".

Bacaan lanjutan

Sen GC, Lengyel P (1992). "The interferon system. A bird's eye view of its biochemistry". J. Biol. Chem. 267 (8): 5017–20. PMID 1371992.
Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
Henco K, Brosius J, Fujisawa A; et al. (1985). "Structural relationship of human interferon alpha genes and pseudogenes". J. Mol. Biol. 185 (2): 227–60. doi:10.1016/0022-2836(85)90401-2. PMID 4057246. Pemeliharaan CS1: Penggunaan et al. yang eksplisit (link) Pemeliharaan CS1: Banyak nama: authors list (link)
Goeddel DV, Leung DW, Dull TJ; et al. (1981). "The structure of eight distinct cloned human leukocyte interferon cDNAs". Nature. 290 (5801): 20–6. doi:10.1038/290020a0. PMID 6163083. Pemeliharaan CS1: Penggunaan et al. yang eksplisit (link) Pemeliharaan CS1: Banyak nama: authors list (link)
Lawn RM, Adelman J, Dull TJ; et al. (1981). "DNA sequence of two closely linked human leukocyte interferon genes". Science. 212 (4499): 1159–62. doi:10.1126/science.6165082. PMID 6165082. Pemeliharaan CS1: Penggunaan et al. yang eksplisit (link) Pemeliharaan CS1: Banyak nama: authors list (link)
Tiefenbrun N, Melamed D, Levy N; et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7): 3934–44. PMC 231390 . PMID 8668211. Pemeliharaan CS1: Penggunaan et al. yang eksplisit (link) Pemeliharaan CS1: Banyak nama: authors list (link)
Hussain M, Gill DS, Liao MJ (1997). "Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population". J. Interferon Cytokine Res. 16 (10): 853–9. doi:10.1089/jir.1996.16.853. PMID 8910771. Pemeliharaan CS1: Banyak nama: authors list (link)
Nyman TA, Tölö H, Parkkinen J, Kalkkinen N (1998). "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes". Biochem. J. 329 ( Pt 2) (Pt 2): 295–302. PMC 1219044 . PMID 9425112. Pemeliharaan CS1: Banyak nama: authors list (link)
Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 . PMID 12477932. Pemeliharaan CS1: Penggunaan et al. yang eksplisit (link) Pemeliharaan CS1: Banyak nama: authors list (link)
Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334. Pemeliharaan CS1: Penggunaan et al. yang eksplisit (link) Pemeliharaan CS1: Banyak nama: authors list (link)

Pensinyalan sel: sitokin

Menurut keluarga

Kemokin

CCL	CCL1 CCL2/MCP-1 CCL3/MIP-1α CCL4/MIP-1β CCL5/RANTES CCL6 CCL7 CCL8 CCL9 CCL11 CCL12 CCL13 CCL14 CCL15 CCL16 CCL17 CCL18 CCL19 CCL20 CCL21 CCL22 CCL23 CCL24 CCL25 CCL26 CCL27 CCL28
CXCL	CXCL1/KC CXCL2 CXCL3 CXCL4 CXCL5 CXCL6 CXCL7 CXCL8/IL8 CXCL9 CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL15 CXCL16 CXCL17
CX3CL	CX3CL1
XCL	XCL1 XCL2

TNF

TNFA
Lymphotoxin
- TNFB/LTA
- TNFC/LTB
TNFSF4
TNFSF5/CD40LG
TNFSF6
TNFSF7
TNFSF8
TNFSF9
TNFSF10
TNFSF11
TNFSF13B
EDA

Interleukin

Tipe I
(menurut
subunit
reseptor)

Rantai γ	IL2/IL15 IL4/IL13 IL7 IL9 IL21
Rantai β	IL3 IL5 GM-CSF
IL6 like/gp130	IL6 IL11 IL27 IL30 IL31 +non IL OSM LIF CNTF CTF1
IL-12 family/IL12RB1	IL12 IL23 IL27 IL35
Other	IL14 IL16 IL32 IL34