Chimerin 2

CHN2
PDBに登録されている構造
PDBオルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧

1XA6

識別子
記号CHN2, ARHGAP3, BCH, CHN2-3, RHOGAP3, chimerin 2
外部IDOMIM: 602857 MGI: 1917243 HomoloGene: 31213 GeneCards: CHN2
遺伝子の位置 (マウス)
6番染色体 (マウス)
染色体6番染色体 (マウス)[1]
6番染色体 (マウス)
CHN2遺伝子の位置
CHN2遺伝子の位置
バンドデータ無し開始点54,016,539 bp[1]
終点54,278,795 bp[1]
RNA発現パターン




さらなる参照発現データ
遺伝子オントロジー
分子機能• 血漿タンパク結合
• 金属イオン結合
• GTPase activator activity
細胞の構成要素• 細胞質
• 細胞質基質
• 膜
生物学的プロセス• intracellular signal transduction
• regulation of small GTPase mediated signal transduction
• シグナル伝達
• positive regulation of signal transduction
• positive regulation of GTPase activity
• regulation of GTPase activity
出典:Amigo / QuickGO
オルソログ
種ヒトマウス
Entrez

1124

69993

Ensembl

ENSG00000106069

ENSMUSG00000004633

UniProt

P52757,B3VCG5,H0YG02

Q80XD1

RefSeq
(mRNA)
NM_001039936
NM_001293069
NM_001293070
NM_001293071
NM_001293072

NM_001293073
NM_001293075
NM_001293076
NM_001293077
NM_001293078
NM_001293079
NM_001293080
NM_001293081
NM_004067
NM_001398427

NM_001163640
NM_023543
NM_001311133
NM_001311134

RefSeq
(タンパク質)
NP_001035025
NP_001279998
NP_001279999
NP_001280000
NP_001280001

NP_001280002
NP_001280004
NP_001280005
NP_001280006
NP_001280007
NP_001280008
NP_001280009
NP_001280010
NP_004058

NP_001157112
NP_001298062
NP_001298063
NP_076032

場所
(UCSC)		n/aChr : 54.02 – 54.28 Mb
PubMed検索[2][3]
ウィキデータ
閲覧/編集 ヒト閲覧/編集 マウス

β-chimaerin（ベータ-キメリン、ベータ-カイメリン）はヒトにおいてCHN2遺伝子にコードされているタンパク質である[4][5]。

この遺伝子はchimerinファミリーのメンバーであり、ホルボールエステル/DAGタイプ亜鉛フィンガー、Rho-GAPドメイン、SH2ドメインを持つタンパク質をコードしている。このタンパク質は、リン脂質結合およびジアシルグリセロール (DAG) の結合が誘導するタンパク質の細胞質ゾルからゴルジ体膜への移行によって制御されているGTPアーゼ活性化タンパク質活性を有する。このタンパク質は平滑筋細胞の増殖および移動に役割を果たしている。この遺伝子の発現の減少は悪性度の高い神経膠腫および乳がんと関連しており、この遺伝子の発現の上昇はリンパ腫と関連している。この遺伝子の変異は、ヒトの統合失調症と関連している。異なるアイソフォームをコードしている選択的転写スプライシングバリアントが同定されている[5]。

脚注

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004633 - Ensembl, May 2017
  2. ^ Human PubMed Reference:
  3. ^ Mouse PubMed Reference:
  4. ^ Leung T, How BE, Manser E, Lim L (Jun 1994), “Cerebellar beta 2-chimaerin, a GTPase-activating protein for p21 ras-related rac is specifically expressed in granule cells and has a unique N-terminal SH2 domain”, J Biol Chem 269 (17): 12888–92, PMID 8175705 
  5. ^ a b “Entrez Gene: CHN2 chimerin (chimaerin) 2”. 2012年1月26日閲覧。

推薦文献

  • Yuan S, Miller DW, Barnett GH, et al. (1995), “Identification and characterization of human beta 2-chimaerin: association with malignant transformation in astrocytoma”, Cancer Res. 55 (15): 3456–61, PMID 7614486 
  • Caloca MJ, Fernandez N, Lewin NE, et al. (1997), “Beta2-chimaerin is a high affinity receptor for the phorbol ester tumor promoters”, J. Biol. Chem. 272 (42): 26488–96, doi:10.1074/jbc.272.42.26488, PMID 9334226 
  • Caloca MJ, Garcia-Bermejo ML, Blumberg PM, et al. (1999), “beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain”, Proc. Natl. Acad. Sci. U.S.A. 96 (21): 11854–9, doi:10.1073/pnas.96.21.11854, PMC 18376, PMID 10518540, http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=18376 
  • Caloca MJ, Wang H, Delemos A, et al. (2001), “Phorbol esters and related analogs regulate the subcellular localization of beta 2-chimaerin, a non-protein kinase C phorbol ester receptor”, J. Biol. Chem. 276 (21): 18303–12, doi:10.1074/jbc.M011368200, PMID 11278894 
  • Wang H, Kazanietz MG (2002), “Chimaerins, novel non-protein kinase C phorbol ester receptors, associate with Tmp21-I (p23): evidence for a novel anchoring mechanism involving the chimaerin C1 domain”, J. Biol. Chem. 277 (6): 4541–50, doi:10.1074/jbc.M107150200, PMID 11689559 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003), “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”, Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903, doi:10.1073/pnas.242603899, PMC 139241, PMID 12477932, http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241 
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003), “Human chromosome 7: DNA sequence and biology”, Science 300 (5620): 767–72, doi:10.1126/science.1083423, PMC 2882961, PMID 12690205, http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2882961 
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  • Hillier LW, Fulton RS, Fulton LA, et al. (2003), “The DNA sequence of human chromosome 7”, Nature 424 (6945): 157–64, doi:10.1038/nature01782, PMID 12853948 
  • Caloca MJ, Wang H, Kazanietz MG (2004), “Characterization of the Rac-GAP (Rac-GTPase-activating protein) activity of beta2-chimaerin, a 'non-protein kinase C' phorbol ester receptor”, Biochem. J. 375 (Pt 2): 313–21, doi:10.1042/BJ20030727, PMC 1223697, PMID 12877655, http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1223697 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004), “Complete sequencing and characterization of 21,243 full-length human cDNAs”, Nat. Genet. 36 (1): 40–5, doi:10.1038/ng1285, PMID 14702039 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004), “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”, Genome Res. 14 (10B): 2121–7, doi:10.1101/gr.2596504, PMC 528928, PMID 15489334, http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928 
  • Canagarajah B, Leskow FC, Ho JY, et al. (2004), “Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin”, Cell 119 (3): 407–18, doi:10.1016/j.cell.2004.10.012, PMID 15507211 
  • Hashimoto R, Yoshida M, Kunugi H, et al. (2005), “A missense polymorphism (H204R) of a Rho GTPase-activating protein, the chimerin 2 gene, is associated with schizophrenia in men”, Schizophrenia Research 73 (2–3): 383–5, doi:10.1016/j.schres.2004.01.017, PMID 15653288 
  • Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005), “High-throughput mapping of a dynamic signaling network in mammalian cells”, Science 307 (5715): 1621–5, doi:10.1126/science.1105776, PMID 15761153 
  • Yang C, Liu Y, Leskow FC, et al. (2005), “Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin.”, J. Biol. Chem. 280 (26): 24363–70, doi:10.1074/jbc.M411629200, PMID 15863513 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006), “Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes”, Genome Res. 16 (1): 55–65, doi:10.1101/gr.4039406, PMC 1356129, PMID 16344560, http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129 
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