뉴로텐신 수용체 1

뉴로텐신 수용체 1(Neurotensin receptor type 1, NTR1)은 인간에서 NTSR1 유전자에 의해 암호화 된 단백질이다.[1][2]

기능

NTR1이라고도 하는 뉴로텐신 수용체 1은 G단백질 결합 수용체의 초 군에 속하며 클래스 A GPCR로 간주된다. NTSR1은 여러 생물학적 변조를 통해 저혈압, 고혈당, 저체온증, 장 운동 및 분비를 조절한다.[2]

리간드

  • ML314-β 어레스틴 편향 작용제[3]
  • 뉴로텐신(NT1)

같이 보기

  • 뉴로텐신 수용체

각주

  1. ↑ “Chromosomal localization of mouse and human neurotensin receptor genes”. 《Mammalian Genome》 5 (5): 303–6. May 1994. doi:10.1007/BF00389545. PMID 8075503. 
  2. ↑ 가 나 “Entrez Gene: NTSR1 neurotensin receptor 1 (high affinity)”. 
  3. ↑ “Discovery of ML314, a Brain Penetrant Non-Peptidic β-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor”. 《ACS Med Chem Lett》 4 (9): 846–851. 2013. doi:10.1021/ml400176n. PMC 3940307. PMID 24611085. 

추가 자료

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