4-Kumarat-KoA ligaza
4-kumarat-KoA ligaza | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifikatori | |||||||||
EC broj | 6.2.1.12 | ||||||||
CAS broj | 37332-51-7 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
|
4-kumarat-KoA ligaza (EC 6.2.1.12, 4-kumaroil-KoA sintetaza, p-kumaroil KoA ligaza, p-kumaril koenzim A sintetaza, p-kumaril-KoA sintetaza, p-kumaril-KoA ligaza, feruloil KoA ligaza, hidroksicinamoil KoA sintetaza, 4-kumarat:koenzim A ligaza, kafeolil koenzim A sintetaza, p-hidroksicinamoil koenzim A sintetaza, feruloil koenzim A sintetaza, sinapoil koenzim A sintetaza, 4-kumaril-KoA sintetaza, hidroksicinamat:KoA ligaza, p-kumaril-KoA ligaza, p-hidroksicinaminska kiselina:KoA ligaza, 4CL) je enzim sa sistematskim imenom 4-kumarat:KoA ligaza (formira AMP).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- ATP + 4-kumarat + KoA AMP + difosfat + 4-kumaroil-KoA
Reference
- ↑ Gross, G.G. and Zenk, M.H. (1974). „Isolation and properties of hydroxycinnamate: CoA ligase from lignifying tissue of Forsythia”. Eur. J. Biochem. 42: 453-459. PMID 4364250.
- ↑ Lindl, T., Kreuzaler, F. and Hahlbrock, F. (1973). „Synthesis of p-coumaroyl coenzyme A with a partially purified p-coumarate:CoA ligase from cell suspension cultures of soybean (Glycine max)”. Biochim. Biophys. Acta 302: 457-464. PMID 4699252.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Spoljašnje veze
- MeSH 4-coumarate---CoA+ligase
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6