Abl (gen)
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ABL proto-onkogen 1, nereceptorska tirozinska kinaza | |||||||||||
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![]() PDB prikaz baziran na 1ab2. | |||||||||||
Dostupne strukture | |||||||||||
1AB2, 1ABL, 1AWO, 1BBZ, 1JU5, 1OPL, 1ZZP, 2ABL, 2E2B, 2F4J, 2FO0, 2G1T, 2G2F, 2G2H, 2G2I, 2GQG, 2HIW, 2HYY, 2HZ0, 2HZ4, 2HZI, 2O88, 2V7A, 3CS9, 3EG0, 3EG1, 3EG2, 3EG3, 3EGU, 3K2M, 3PYY, 3QRI, 3QRJ, 3QRK, 3T04, 3UE4, 3UYO, 4J9B, 4J9C, 4J9D, 4J9E, 4J9F, 4J9G, 4J9H, 4J9I, 4JJB, 4JJC, 4JJD | |||||||||||
Identifikatori | |||||||||||
Simboli | ABL1; ABL; JTK7; bcr/abl; c-ABL; c-ABL1; p150; v-abl | ||||||||||
Vanjski ID | OMIM: 189980 MGI: 87859 HomoloGene: 3783 GeneCards: ABL1 Gene | ||||||||||
EC broj | 2.7.10.2 | ||||||||||
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Pregled RNK izražavanja | |||||||||||
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podaci | |||||||||||
Ortolozi | |||||||||||
Vrsta | Čovek | Miš | |||||||||
Entrez | 25 | 11350 | |||||||||
Ensembl | ENSG00000097007 | ENSMUSG00000026842 | |||||||||
UniProt | P00519 | P00520 | |||||||||
Ref. Sekv. (iRNK) | NM_005157 | NM_001112703 | |||||||||
Ref. Sekv. (protein) | NP_005148 | NP_001106174 | |||||||||
Lokacija (UCSC) | Chr 9: 133.59 - 133.76 Mb | Chr 2: 31.69 - 31.8 Mb | |||||||||
PubMed pretraga | [1] | [2] |
Abelsonov mišji leukemijski viralni onkogen homolog 1 (ABL1) protein je koji je kod ljudi kodiran ABL1 genom (raniji simbol ABL) lociranim na hromozomu 9.[1] c-Abl se ponekad koristi za imenovanje verzije gena prisutnog u genomu sisara, dok se v-Abl odnosi na viralni gen.
Interakcije
Abl gen formira interakcije sa:
- ABI1,[2][3][4]
- ABI2,[5][6]
- ABL2,[5]
- ATM,[7][8][9]
- BCAR1,[10][11]
- BCR,[12][13][14]
- BRCA1,[15]
- CAT,[16]
- CBL,[17][18]
- CRKL,[19][20][21]
- DOK1,[22][23]
- EPHB2,[24]
- GPX1,[25]
- GRB10,[26][27]
- MTOR,[28]
- GRB2,[19][29]
- MDM2,[30]
- NCK1,[17][19]
- NEDD9,[31][32]
- NTRK1,[33][34]
- P73,[35][36]
- PAG1,[37]
- PAK2,[38]
- PSTPIP1,[39]
- RAD9A,[40]
- RAD51,[7]
- RB1,[41][42]
- RFX1,[43]
- RYBP,[44]
- SHC1,[12][45]
- SORBS2,[18][46]
- SPTA1,[47]
- SPTAN1,[47]
- TERF1,[9]
- VAV1,[48] and
- YTHDC1.[49]
Regulacija
Postoje izvesni dokazi da je izražavanje Abl regulisano posredstvom mikroRNK miR-203.[50]
Povezano
- BCR gen
Reference
- ↑ Szczylik C, Skorski T, Nicolaides NC, Manzella L, Malaguarnera L, Venturelli D, Gewirtz AM, Calabretta B (August 1991). „Selective inhibition of leukemia cell proliferation by BCR-ABL antisense oligodeoxynucleotides”. Science 253 (5019): 562–5. DOI:10.1126/science.1857987. PMID 1857987.
- ↑ Tani K, Sato Seiichi, Sukezane Taiko, Kojima Hiroshi, Hirose Hidenori, Hanafusa Hidesaburo, Shishido Tomoyuki (June 2003). „Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase”. J. Biol. Chem. 278 (24): 21685–92. DOI:10.1074/jbc.M301447200. PMID 12672821.
- ↑ Biesova Z, Piccoli C, Wong W T (January 1997). „Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth”. Oncogene 14 (2): 233–41. DOI:10.1038/sj.onc.1200822. PMID 9010225.
- ↑ Yamamoto A, Suzuki T, Sakaki Y (June 2001). „Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease”. Gene 271 (2): 159–69. DOI:10.1016/S0378-1119(01)00521-2. PMID 11418237.
- ↑ 5,0 5,1 Cao C, Leng Yumei, Li Chufang, Kufe Donald (April 2003). „Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response”. J. Biol. Chem. 278 (15): 12961–7. DOI:10.1074/jbc.M300058200. PMID 12569093.
- ↑ Dai Z, Pendergast A M (November 1995). „Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity”. Genes Dev. 9 (21): 2569–82. DOI:10.1101/gad.9.21.2569. PMID 7590236.
- ↑ 7,0 7,1 Chen G, Yuan S S, Liu W, Xu Y, Trujillo K, Song B, Cong F, Goff S P, Wu Y, Arlinghaus R, Baltimore D, Gasser P J, Park M S, Sung P, Lee E Y (April 1999). „Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl”. J. Biol. Chem. 274 (18): 12748–52. DOI:10.1074/jbc.274.18.12748. PMID 10212258.
- ↑ Shafman T, Khanna K K, Kedar P, Spring K, Kozlov S, Yen T, Hobson K, Gatei M, Zhang N, Watters D, Egerton M, Shiloh Y, Kharbanda S, Kufe D, Lavin M F (May 1997). „Interaction between ATM protein and c-Abl in response to DNA damage”. Nature 387 (6632): 520–3. DOI:10.1038/387520a0. PMID 9168117.
- ↑ 9,0 9,1 Kishi S, Zhou X Z, Ziv Y, Khoo C, Hill D E, Shiloh Y, Lu K P (August 2001). „Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks”. J. Biol. Chem. 276 (31): 29282–91. DOI:10.1074/jbc.M011534200. PMID 11375976.
- ↑ Salgia R, Pisick E, Sattler M, Li J L, Uemura N, Wong W K, Burky S A, Hirai H, Chen L B, Griffin J D (October 1996). „p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene”. J. Biol. Chem. 271 (41): 25198–203. DOI:10.1074/jbc.271.41.25198. PMID 8810278.
- ↑ Mayer BJ, Hirai H, Sakai R (March 1995). „Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases”. Curr. Biol. 5 (3): 296–305. DOI:10.1016/S0960-9822(95)00060-1. PMID 7780740.
- ↑ 12,0 12,1 Puil L, Liu J, Gish G, Mbamalu G, Bowtell D, Pelicci P G, Arlinghaus R, Pawson T (February 1994). „Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway”. EMBO J. 13 (4): 764–73. PMC 394874. PMID 8112292.
- ↑ Ling X, Ma Guozhen, Sun Tong, Liu Jiaxin, Arlinghaus Ralph B (January 2003). „Bcr and Abl interaction: oncogenic activation of c-Abl by sequestering Bcr”. Cancer Res. 63 (2): 298–303. PMID 12543778.
- ↑ Pendergast AM, Muller A J, Havlik M H, Maru Y, Witte O N (July 1991). „BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner”. Cell 66 (1): 161–71. DOI:10.1016/0092-8674(91)90148-R. PMID 1712671.
- ↑ Foray N, Marot Didier, Randrianarison Voahangy, Venezia Nicole Dalla, Picard Didier, Perricaudet Michel, Favaudon Vincent, Jeggo Penny (June 2002). „Constitutive Association of BRCA1 and c-Abl and Its ATM-Dependent Disruption after Irradiation”. Mol. Cell. Biol. 22 (12): 4020–32. DOI:10.1128/MCB.22.12.4020-4032.2002. PMC 133860. PMID 12024016.
- ↑ Cao C, Leng Yumei, Kufe Donald (August 2003). „Catalase activity is regulated by c-Abl and Arg in the oxidative stress response”. J. Biol. Chem. 278 (32): 29667–75. DOI:10.1074/jbc.M301292200. PMID 12777400.
- ↑ 17,0 17,1 Miyoshi-Akiyama T, Aleman L M, Smith J M, Adler C E, Mayer B J (July 2001). „Regulation of Cbl phosphorylation by the Abl tyrosine kinase and the Nck SH2/SH3 adaptor”. Oncogene 20 (30): 4058–69. DOI:10.1038/sj.onc.1204528. PMID 11494134.
- ↑ 18,0 18,1 Soubeyran P, Barac Ana, Szymkiewicz Iwona, Dikic Ivan (February 2003). „Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl”. Biochem. J. 370 (Pt 1): 29–34. DOI:10.1042/BJ20021539. PMC 1223168. PMID 12475393.
- ↑ 19,0 19,1 19,2 Ren R, Ye Z S, Baltimore D (April 1994). „Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites”. Genes Dev. 8 (7): 783–95. DOI:10.1101/gad.8.7.783. PMID 7926767.
- ↑ Heaney C, Kolibaba K, Bhat A, Oda T, Ohno S, Fanning S, Druker B J (January 1997). „Direct binding of CRKL to BCR-ABL is not required for BCR-ABL transformation”. Blood 89 (1): 297–306. PMID 8978305.
- ↑ Kyono WT, de Jong R, Park R K, Liu Y, Heisterkamp N, Groffen J, Durden D L (November 1998). „Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc gamma RI)”. J. Immunol. 161 (10): 5555–63. PMID 9820532.
- ↑ van Dijk TB, van Den Akker E, Amelsvoort M P, Mano H, Löwenberg B, von Lindern M (November 2000). „Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells”. Blood 96 (10): 3406–13. PMID 11071635.
- ↑ Yamanashi Y, Baltimore D (January 1997). „Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok”. Cell 88 (2): 205–11. DOI:10.1016/S0092-8674(00)81841-3. PMID 9008161.
- ↑ Yu HH, Zisch A H, Dodelet V C, Pasquale E B (July 2001). „Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor”. Oncogene 20 (30): 3995–4006. DOI:10.1038/sj.onc.1204524. PMID 11494128.
- ↑ Cao C, Leng Yumei, Huang Wei, Liu Xuan, Kufe Donald (October 2003). „Glutathione peroxidase 1 is regulated by the c-Abl and Arg tyrosine kinases”. J. Biol. Chem. 278 (41): 39609–14. DOI:10.1074/jbc.M305770200. PMID 12893824.
- ↑ Bai RY, Jahn T, Schrem S, Munzert G, Weidner K M, Wang J Y, Duyster J (August 1998). „The SH2-containing adapter protein GRB10 interacts with BCR-ABL”. Oncogene 17 (8): 941–8. DOI:10.1038/sj.onc.1202024. PMID 9747873.
- ↑ Frantz JD, Giorgetti-Peraldi S, Ottinger E A, Shoelson S E (January 1997). „Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains”. J. Biol. Chem. 272 (5): 2659–67. DOI:10.1074/jbc.272.5.2659. PMID 9006901.
- ↑ Kumar V, Sabatini D, Pandey P, Gingras A C, Majumder P K, Kumar M, Yuan Z M, Carmichael G, Weichselbaum R, Sonenberg N, Kufe D, Kharbanda S (April 2000). „Regulation of the rapamycin and FKBP-target 1/mammalian target of rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinase”. J. Biol. Chem. 275 (15): 10779–87. DOI:10.1074/jbc.275.15.10779. PMID 10753870.
- ↑ Warmuth M, Bergmann M, Priess A, Häuslmann K, Emmerich B, Hallek M (December 1997). „The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr”. J. Biol. Chem. 272 (52): 33260–70. DOI:10.1074/jbc.272.52.33260. PMID 9407116.
- ↑ Goldberg Z, Vogt Sionov Ronit, Berger Michael, Zwang Yaara, Perets Ruth, Van Etten Richard A, Oren Moshe, Taya Yoichi, Haupt Ygal (July 2002). „Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation”. EMBO J. 21 (14): 3715–27. DOI:10.1093/emboj/cdf384. PMC 125401. PMID 12110584.
- ↑ Minegishi M, Tachibana K, Sato T, Iwata S, Nojima Y, Morimoto C (October 1996). „Structure and function of Cas-L, a 105-kD Crk-associated substrate- related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes”. J. Exp. Med. 184 (4): 1365–75. DOI:10.1084/jem.184.4.1365. PMC 2192828. PMID 8879209.
- ↑ Law SF, Estojak J, Wang B, Mysliwiec T, Kruh G, Golemis E A (July 1996). „Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae”. Mol. Cell. Biol. 16 (7): 3327–37. PMC 231327. PMID 8668148.
- ↑ Koch A, Mancini A, Stefan M, Niedenthal R, Niemann H, Tamura T (March 2000). „Direct interaction of nerve growth factor receptor, TrkA, with non-receptor tyrosine kinase, c-Abl, through the activation loop”. FEBS Lett. 469 (1): 72–6. DOI:10.1016/S0014-5793(00)01242-4. PMID 10708759.
- ↑ Yano H, Cong F, Birge R B, Goff S P, Chao M V (February 2000). „Association of the Abl tyrosine kinase with the Trk nerve growth factor receptor”. J. Neurosci. Res. 59 (3): 356–64. DOI:10.1002/(SICI)1097-4547(20000201)59:3<356::AID-JNR9>3.0.CO;2-G. PMID 10679771.
- ↑ Yuan ZM, Shioya H, Ishiko T, Sun X, Gu J, Huang Y Y, Lu H, Kharbanda S, Weichselbaum R, Kufe D (June 1999). „p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage”. Nature 399 (6738): 814–7. DOI:10.1038/21704. PMID 10391251.
- ↑ Agami R, Blandino G, Oren M, Shaul Y (June 1999). „Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis”. Nature 399 (6738): 809–13. DOI:10.1038/21697. PMID 10391250.
- ↑ Wen ST, Van Etten R A (October 1997). „The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity”. Genes Dev. 11 (19): 2456–67. DOI:10.1101/gad.11.19.2456. PMC 316562. PMID 9334312.
- ↑ Roig J, Tuazon P T, Zipfel P A, Pendergast A M, Traugh J A (December 2000). „Functional interaction between c-Abl and the p21-activated protein kinase γ-PAK”. PNAS 97 (26): 14346–51. DOI:10.1073/pnas.97.26.14346. PMC 18921. PMID 11121037.
- ↑ Cong F, Spencer S, Côté J F, Wu Y, Tremblay M L, Lasky L A, Goff S P (December 2000). „Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation”. Mol. Cell 6 (6): 1413–23. DOI:10.1016/S1097-2765(00)00138-6. PMID 11163214.
- ↑ Yoshida K, Komatsu Kiyoshi, Wang Hong-Gang, Kufe Donald (May 2002). „c-Abl Tyrosine Kinase Regulates the Human Rad9 Checkpoint Protein in Response to DNA Damage”. Mol. Cell. Biol. 22 (10): 3292–300. DOI:10.1128/MCB.22.10.3292-3300.2002. PMC 133797. PMID 11971963.
- ↑ Miyamura T, Nishimura J, Yufu Y, Nawata H (February 1997). „Interaction of BCR-ABL with the retinoblastoma protein in Philadelphia chromosome-positive cell lines”. Int. J. Hematol. 65 (2): 115–21. DOI:10.1016/S0925-5710(96)00539-7. PMID 9071815.
- ↑ Welch PJ, Wang J Y (November 1993). „A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle”. Cell 75 (4): 779–90. DOI:10.1016/0092-8674(93)90497-E. PMID 8242749.
- ↑ Agami R, Shaul Y (April 1998). „The kinase activity of c-Abl but not v-Abl is potentiated by direct interaction with RFXI, a protein that binds the enhancers of several viruses and cell-cycle regulated genes”. Oncogene 16 (14): 1779–88. DOI:10.1038/sj.onc.1201708. PMID 9583676.
- ↑ Zhu J, Shore S K (December 1996). „c-ABL tyrosine kinase activity is regulated by association with a novel SH3-domain-binding protein”. Mol. Cell. Biol. 16 (12): 7054–62. PMC 231708. PMID 8943360.
- ↑ Wisniewski D, Strife A, Swendeman S, Erdjument-Bromage H, Geromanos S, Kavanaugh W M, Tempst P, Clarkson B (April 1999). „A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells”. Blood 93 (8): 2707–20. PMID 10194451.
- ↑ Wang B, Golemis E A, Kruh G D (July 1997). „ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks”. J. Biol. Chem. 272 (28): 17542–50. DOI:10.1074/jbc.272.28.17542. PMID 9211900.
- ↑ 47,0 47,1 Ziemnicka-Kotula D, Xu J, Gu H, Potempska A, Kim K S, Jenkins E C, Trenkner E, Kotula L (May 1998). „Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton”. J. Biol. Chem. 273 (22): 13681–92. DOI:10.1074/jbc.273.22.13681. PMID 9593709.
- ↑ Bassermann F, Jahn Thomas, Miething Cornelius, Seipel Petra, Bai Ren-Yuan, Coutinho Sunita, Tybulewicz Victor L, Peschel Christian, Duyster Justus (April 2002). „Association of Bcr-Abl with the proto-oncogene Vav is implicated in activation of the Rac-1 pathway”. J. Biol. Chem. 277 (14): 12437–45. DOI:10.1074/jbc.M112397200. PMID 11790798.
- ↑ Rafalska I, Zhang Zhaiyi, Benderska Natalya, Wolff Horst, Hartmann Annette M, Brack-Werner Ruth, Stamm Stefan (August 2004). „The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation”. Hum. Mol. Genet. 13 (15): 1535–49. DOI:10.1093/hmg/ddh167. PMID 15175272.
- ↑ Bueno MJ, Pérez de Castro I, Gómez de Cedrón M, Santos J, Calin GA, Cigudosa JC, Croce CM, Fernández-Piqueras J, Malumbres M (June 2008). „Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression”. Cancer Cell 13 (6): 496–506. DOI:10.1016/j.ccr.2008.04.018. PMID 18538733.
Literatura
- Shore SK, Tantravahi RV, Reddy EP (December 2002). „Transforming pathways activated by the v-Abl tyrosine kinase”. Oncogene 21 (56): 8568–76. DOI:10.1038/sj.onc.1206084. PMID 12476303.
- Shaul Y (2000). „c-Abl: activation and nuclear targets”. Cell Death Differ. 7 (1): 10–6. DOI:10.1038/sj.cdd.4400626. PMID 10713716.
- Era T (2002). „Bcr-Abl is a "molecular switch" for the decision for growth and differentiation in hematopoietic stem cells”. Int. J. Hematol. 76 (1): 35–43. DOI:10.1007/BF02982716. PMID 12138893.
- Pendergast AM (2003). „The Abl family kinases: mechanisms of regulation and signaling”. Adv. Cancer Res. 85: 51–100. DOI:10.1016/S0065-230X(02)85003-5. PMID 12374288.
- Keung YK, Beaty M, Steward W, et al. (2003). „Chronic myelocytic leukemia with eosinophilia, t(9;12)(q34;p13), and ETV6-ABL gene rearrangement: case report and review of the literature”. Cancer Genet. Cytogenet. 138 (2): 139–42. DOI:10.1016/S0165-4608(02)00609-X. PMID 12505259.
- Saglio G, Cilloni D (2005). „Abl: the prototype of oncogenic fusion proteins”. Cell. Mol. Life Sci. 61 (23): 2897–911. DOI:10.1007/s00018-004-4271-0. PMID 15583852.
- Shaul Y, Ben-Yehoyada M (2005). „Role of c-Abl in the DNA damage stress response”. Cell Res. 15 (1): 33–5. DOI:10.1038/sj.cr.7290261. PMID 15686624.
- Yoshida K (2007). „Regulation for nuclear targeting of the Abl tyrosine kinase in response to DNA damage”. Adv. Exp. Med. Biol. 604: 155–65. DOI:10.1007/978-0-387-69116-9_15. PMID 17695727.
Vanjske veze
- MeSH Genes,+abl
- Online Mendelovsko nasleđivanje kod čoveka (OMIM) 189980 (ABL)
- MeSH Abelson+Leukemia+Virus
- Drosophila Abl tyrosine kinase - The Interactive Fly
- ABL1 Arhivirano 2011-07-04 na Wayback Machine-u Info with links in the Cell Migration Gateway Arhivirano 2014-12-11 na Wayback Machine-u
- ABL1 Arhivirano 2011-11-04 na Wayback Machine-u on the Atlas of Genetics and Cytogenetics in Oncology and Haematology
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