Bromizoval
Bromizoval | |||
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IUPAC ime |
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Identifikacija | |||
CAS registarski broj | 496-67-3 ![]() ![]() | ||
PubChem[1][2] | 2447, 146955 R, 735997 S | ||
ChemSpider[3] | 2353 ![]() ![]() ![]() | ||
UNII | 469GW8R486 ![]() | ||
EINECS broj | 207-825-7 | ||
KEGG[4] | D01391 | ||
MeSH | Bromisovalum | ||
ChEMBL[5] | CHEMBL1515611 ![]() | ||
ATC code | N05CM03 | ||
Jmol-3D slike | Slika 1 Slika 2 | ||
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Svojstva | |||
Molekulska formula | C6H11BrN2O2 | ||
Molarna masa | 223.07 g mol−1 | ||
log P | 1,057 | ||
pKa | 10,536 | ||
Baznost (pKb) | 3;461 | ||
Farmakologija | |||
Načini upotrebe | Oralno | ||
Srodna jedinjenja | |||
Srodna ureje | Karbromal | ||
Srodna jedinjenja |
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Infobox references |
Bromizoval (bromvalerilureja) je hipnotik i sedativ koji je bio otkriven 1907.[6] One je u prodaji na slobodno u Aziji pod mnoštvom naziva (kao što je Brovarin[7]). On se obično koristi u kombinaciji sa nesteroidnim antiinflamatornim lekovima.
Hronična upotreba bromizovala je vezana za trovanje bromom.[8][9][10][11]
Reference
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ US patent 914518, "Alpha-halogen-isovaleryl-urea and process of making the same", issued 09. 03. 1909., assigned to Knoll
- ↑ „Bromisoval”. International. Drugs.com.
- ↑ Hashida, H.; Honda, T.; Morimoto, H.; Aibara, Y. (2001). „A case of chronic bromvalerylurea intoxication due to habitual use of commercially available nonsteroidal anti-inflammatory drugs presenting an indefinite hyperchloremia” (japanese) (pdf). Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics 38 (5): 700–703. DOI:10.3143/geriatrics.38.700. ISSN 0300-9173. PMID 11605223.
- ↑ Kawakami, T.; Takiyama, Y.; Yanaka, I.; Taguchi, T.; Tanaka, Y.; Nishizawa, M.; Nakano, I. (1998). „Chronic bromvalerylurea intoxication: Dystonic posture and cerebellar ataxia due to nonsteroidal anti-inflammatory drug abuse” (pdf). Internal Medicine (Tokyo, Japan) 37 (9): 788–791. DOI:10.2169/internalmedicine.37.788. PMID 9804091.
- ↑ Wang, Y. -T.; Yang, S. Y.; Wu, V. C.; Wu, K. D.; Fang, C. C. (2005). „Pseudohyperchloraemia due to bromvalerylurea abuse”. Nephrology Dialysis Transplantation 20 (8): 1767–1768. DOI:10.1093/ndt/gfh945. PMID 15972320.
- ↑ Arai, A.; Sato, M.; Hozumi, I.; Matsubara, N.; Tanaka, K.; Soma, Y.; Adachi, T.; Tsuji, S. (1997). „Cerebellar Ataxia and Peripheral Neuropathy due to Chronic Bromvalerylurea Poisoning” (pdf). Internal Medicine (Tokyo, Japan) 36 (10): 742–746. DOI:10.2169/internalmedicine.36.742. PMID 9372340.
Povezano
Spoljašnje veze
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Dialkil-fenoli | |||||||||
CL-218,872 • Eszopiklon • Indiplon • Nekopidem • Pazinaklon • ROD-188 • Saripidem • Suproklon • Suriklon • SX-3228 • U-89843A • U-90042 • Zaleplon • Zolpidem • Zopiklon | |||||||||
Neuroaktivni steroidi |
receptor
Acetilholinski receptor
α1- adrenergički
Selektivni 5-HT2A & α1-adrenergički antagonisti |
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GHB receptor
GHB Tip |
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Oreksinski antagonisti |
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negrupisani
Drugi | 2-Metil-2-butanol • Acekarbromal • Acetofenon • Apronal • Bromidi • Bromizoval • Karbromal • Hloralosa • Klometiazol • Embutramid • Etomidat • Evoksin • Fenadiazol • Gaboksadol • Loreklezol • Mefenoksalon • Sulfonmetan • Trihloroetanol • Triklofos • Valerian • Valnoktamid |
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