CD117
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V-kit Hardi-Zakerman 4, homolog mačijeg sarkoma viralnog onkogena | |||||||||||
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![]() PDB prikaz baziran na 1pkg. | |||||||||||
Dostupne strukture | |||||||||||
1PKG, 1T45, 1T46, 2E9W, 2EC8, 2VIF, 3G0E, 3G0F | |||||||||||
Identifikatori | |||||||||||
Simboli | KIT; C-Kit; CD117; PBT; SCFR | ||||||||||
Vanjski ID | OMIM: 164920 MGI: 96677 HomoloGene: 187 GeneCards: KIT Gene | ||||||||||
EC broj | 2.7.10.1 | ||||||||||
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Ortolozi | |||||||||||
Vrsta | Čovek | Miš | |||||||||
Entrez | 3815 | 16590 | |||||||||
Ensembl | ENSG00000157404 | ENSMUSG00000005672 | |||||||||
UniProt | P10721 | P05532 | |||||||||
RefSeq (mRNA) | NM_000222.2 | NM_001122733.1 | |||||||||
RefSeq (protein) | NP_000213.1 | NP_001116205.1 | |||||||||
Lokacija (UCSC) | Chr 4: 55.52 - 55.61 Mb | Chr 5: 75.97 - 76.05 Mb | |||||||||
PubMed pretraga | [1] | [2] |
Receptor faktora rasta mastocita/matičnih ćelija (engl. Mast/stem cell growth factor receptor - SCFR), takođe poznat kao proto-onkogen c-Kit ili tirozinska proteinska kinaza Kit ili CD117, je protein koji je kod ljudi kodiran KIT genom.[1] Višestruke transkriptne varijante koje kodiraju različite izoforme ovog gena su poznate.[2] KIT prvi opisao nemački biohemičar Aksel Ulrič 1987. kao ćelijski homolog mačijeg sarkomnog viralnog onkogena v-kit.[3]
Interakcije
CD117 formira interakcije sa:
- APS,[4]
- BCR,[5]
- CD63,[6]
- CD81,[6]
- CD9,[6]
- CRK,[7][7]
- CRKL,[8][9]
- DOK1,[10]
- FES,[11][11]
- GRB10,[12]
- Grb2,[13][14][15]
- KITLG,[16][17]
- LNK,[18]
- LYN,[10][19]
- MATK,[20][21]
- MPDZ,[22]
- PIK3R1,[8][13][23]
- PTPN11,[24][25]
- PTPN6,[25][26]
- STAT1,[27]
- SOCS1,[13]
- SOCS6,[28]
- SRC,[29] i
- TEC.[30]
Reference
- ↑ Andre C, Hampe A, Lachaume P, Martin E, Wang XP, Manus V, Hu WX, Galibert F (January 1997). „Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes”. Genomics 39 (2): 216–26. DOI:10.1006/geno.1996.4482. PMID 9027509.
- ↑ „Entrez Gene: KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog”.
- ↑ Yarden Y, Kuang WJ, Yang-Feng T, Coussens L, Munemitsu S, Dull TJ, Chen E, Schlessinger J, Francke U, Ullrich A (November 1987). „Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand”. EMBO J. 6 (11): 3341–51. PMC 553789. PMID 2448137.
- ↑ Wollberg P, Lennartsson J, Gottfridsson E, Yoshimura A, Rönnstrand L (March 2003). „The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit”. Biochem. J. 370 (Pt 3): 1033–8. DOI:10.1042/BJ20020716. PMC 1223215. PMID 12444928.
- ↑ Hallek M, Danhauser-Riedl S, Herbst R, Warmuth M, Winkler A, Kolb HJ, Druker B, Griffin JD, Emmerich B, Ullrich A (July 1996). „Interaction of the receptor tyrosine kinase p145c-kit with the p210bcr/abl kinase in myeloid cells”. Br. J. Haematol. 94 (1): 5–16. DOI:10.1046/j.1365-2141.1996.6102053.x. PMID 8757502.
- ↑ 6,0 6,1 6,2 Anzai N, Lee Y, Youn BS, Fukuda S, Kim YJ, Mantel C, Akashi M, Broxmeyer HE (June 2002). „C-kit associated with the transmembrane 4 superfamily proteins constitutes a functionally distinct subunit in human hematopoietic progenitors”. Blood 99 (12): 4413–21. DOI:10.1182/blood.V99.12.4413. PMID 12036870.
- ↑ 7,0 7,1 Lennartsson J, Wernstedt C, Engström U, Hellman U, Rönnstrand L (August 2003). „Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk”. Exp. Cell Res. 288 (1): 110–8. DOI:10.1016/S0014-4827(03)00206-4. PMID 12878163.
- ↑ 8,0 8,1 van Dijk TB, van Den Akker E, Amelsvoort MP, Mano H, Löwenberg B, von Lindern M (November 2000). „Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells”. Blood 96 (10): 3406–13. PMID 11071635.
- ↑ Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD (April 1997). „Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)”. J. Biol. Chem. 272 (15): 10248–53. DOI:10.1074/jbc.272.15.10248. PMID 9092574.
- ↑ 10,0 10,1 Liang X, Wisniewski D, Strife A, Shivakrupa, Clarkson B, Resh MD (April 2002). „Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling”. J. Biol. Chem. 277 (16): 13732–8. DOI:10.1074/jbc.M200277200. PMID 11825908.
- ↑ 11,0 11,1 Voisset E, Lopez S, Chaix A, Vita M, George C, Dubreuil P, De Sepulveda P (February 2010). „FES kinase participates in KIT-ligand induced chemotaxis”. Biochem. Biophys. Res. Commun. 393 (1): 174–8. DOI:10.1016/j.bbrc.2010.01.116. PMID 20117079.
- ↑ Jahn T, Seipel P, Urschel S, Peschel C, Duyster J (February 2002). „Role for the adaptor protein Grb10 in the activation of Akt”. Mol. Cell. Biol. 22 (4): 979–91. DOI:10.1128/MCB.22.4.979-991.2002. PMC 134632. PMID 11809791.
- ↑ 13,0 13,1 13,2 De Sepulveda P, Okkenhaug K, Rose JL, Hawley RG, Dubreuil P, Rottapel R (February 1999). „Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation”. EMBO J. 18 (4): 904–15. DOI:10.1093/emboj/18.4.904. PMC 1171183. PMID 10022833.
- ↑ Thömmes K, Lennartsson J, Carlberg M, Rönnstrand L (July 1999). „Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor”. Biochem. J. 341 ( Pt 1): 211–6. DOI:10.1042/0264-6021:3410211. PMC 1220349. PMID 10377264.
- ↑ Feng GS, Ouyang YB, Hu DP, Shi ZQ, Gentz R, Ni J (May 1996). „Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway”. J. Biol. Chem. 271 (21): 12129–32. DOI:10.1074/jbc.271.21.12129. PMID 8647802.
- ↑ Lev S, Yarden Y, Givol D (May 1992). „A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses”. J. Biol. Chem. 267 (15): 10866–73. PMID 1375232.
- ↑ Blechman JM, Lev S, Brizzi MF, Leitner O, Pegoraro L, Givol D, Yarden Y (February 1993). „Soluble c-kit proteins and antireceptor monoclonal antibodies confine the binding site of the stem cell factor”. J. Biol. Chem. 268 (6): 4399–406. PMID 7680037.
- ↑ Gueller S, Gery S, Nowak V, Liu L, Serve H, Koeffler HP (October 2008). „Adaptor protein Lnk associates with Tyr(568) in c-Kit”. Biochem. J. 415 (2): 241–5. DOI:10.1042/BJ20080102. PMID 18588518.
- ↑ Linnekin D, DeBerry CS, Mou S (October 1997). „Lyn associates with the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells”. J. Biol. Chem. 272 (43): 27450–5. DOI:10.1074/jbc.272.43.27450. PMID 9341198.
- ↑ Jhun BH, Rivnay B, Price D, Avraham H (April 1995). „The MATK tyrosine kinase interacts in a specific and SH2-dependent manner with c-Kit”. J. Biol. Chem. 270 (16): 9661–6. DOI:10.1074/jbc.270.16.9661. PMID 7536744.
- ↑ Price DJ, Rivnay B, Fu Y, Jiang S, Avraham S, Avraham H (February 1997). „Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes”. J. Biol. Chem. 272 (9): 5915–20. DOI:10.1074/jbc.272.9.5915. PMID 9038210.
- ↑ Mancini A, Koch A, Stefan M, Niemann H, Tamura T (September 2000). „The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity”. FEBS Lett. 482 (1-2): 54–8. DOI:10.1016/S0014-5793(00)02036-6. PMID 11018522.
- ↑ Serve H, Hsu YC, Besmer P (February 1994). „Tyrosine residue 719 of the c-kit receptor is essential for binding of the P85 subunit of phosphatidylinositol (PI) 3-kinase and for c-kit-associated PI 3-kinase activity in COS-1 cells”. J. Biol. Chem. 269 (8): 6026–30. PMID 7509796.
- ↑ Tauchi T, Feng GS, Marshall MS, Shen R, Mantel C, Pawson T, Broxmeyer HE (October 1994). „The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells”. J. Biol. Chem. 269 (40): 25206–11. PMID 7523381.
- ↑ 25,0 25,1 Kozlowski M, Larose L, Lee F, Le DM, Rottapel R, Siminovitch KA (April 1998). „SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain”. Mol. Cell. Biol. 18 (4): 2089–99. PMC 121439. PMID 9528781.
- ↑ Yi T, Ihle JN (June 1993). „Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand”. Mol. Cell. Biol. 13 (6): 3350–8. PMC 359793. PMID 7684496.
- ↑ Deberry C, Mou S, Linnekin D (October 1997). „Stat1 associates with c-kit and is activated in response to stem cell factor”. Biochem. J. 327 ( Pt 1): 73–80. PMC 1218765. PMID 9355737.
- ↑ Bayle J, Letard S, Frank R, Dubreuil P, De Sepulveda P (March 2004). „Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling”. J. Biol. Chem. 279 (13): 12249–59. DOI:10.1074/jbc.M313381200. PMID 14707129.
- ↑ Lennartsson J, Blume-Jensen P, Hermanson M, Pontén E, Carlberg M, Rönnstrand L (September 1999). „Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction”. Oncogene 18 (40): 5546–53. DOI:10.1038/sj.onc.1202929. PMID 10523831.
- ↑ Tang B, Mano H, Yi T, Ihle JN (December 1994). „Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding”. Mol. Cell. Biol. 14 (12): 8432–7. PMC 359382. PMID 7526158.
Literatura
- Lennartsson J, Rönnstrand L (2006). „The stem cell factor receptor/c-Kit as a drug target in cancer”. Curr. Cancer Drug Targ. 6 (1): 65–75. DOI:10.2174/156800906775471725. PMID 16475976.
- Rönnstrand L (2004). „Signal transduction via the stem cell factor receptor/c-Kit”. Cell. Mol. Life Sci. 61 (19–20): 2535–2548. DOI:10.1007/s00018-004-4189-6. PMID 15526160.
- Linnekin D (2000). „Early signaling pathways activated by c-Kit in hematopoietic cells”. Int. J. Biochem. Cell Biol. 31 (10): 1053–74. DOI:10.1016/S1357-2725(99)00078-3. PMID 10582339.
- Canonico B, Felici C, Papa S (2001). „CD117”. J. Biol. Regul. Homeost. Agents 15 (1): 90–4. PMID 11388751.
- Gupta R, Bain BJ, Knight CL (2002). „Cytogenetic and molecular genetic abnormalities in systemic mastocytosis”. Acta Haematol. 107 (2): 123–8. DOI:10.1159/000046642. PMID 11919394.
- Valent P, Ghannadan M, Hauswirth AW, et al. (2003). „Signal transduction-associated and cell activation-linked antigens expressed in human mast cells”. Int. J. Hematol. 75 (4): 357–62. DOI:10.1007/BF02982124. PMID 12041664.
- Sandberg AA, Bridge JA (2002). „Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. gastrointestinal stromal tumors”. Cancer Genet. Cytogenet. 135 (1): 1–22. DOI:10.1016/S0165-4608(02)00546-0. PMID 12072198.
- Kitamura Y, Hirotab S (2005). „Kit as a human oncogenic tyrosine kinase”. Cell. Mol. Life Sci. 61 (23): 2924–31. DOI:10.1007/s00018-004-4273-y. PMID 15583854.
- Larizza L, Magnani I, Beghini A (2005). „The Kasumi-1 cell line: a t(8;21)-kit mutant model for acute myeloid leukemia”. Leuk. Lymphoma 46 (2): 247–55. DOI:10.1080/10428190400007565. PMID 15621809.
- Miettinen M, Lasota J (2006). „KIT (CD117): a review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation”. Appl. Immunohistochem. Mol. Morphol. 13 (3): 205–20. PMID 16082245.
- Lasota J, Miettinen M (2007). „KIT and PDGFRA mutations in gastrointestinal stromal tumors (GISTs)”. Semin Diagn Pathol 23 (2): 91–102. DOI:10.1053/j.semdp.2006.08.006. PMID 17193822.
- Patnaik MM, Tefferi A, Pardanani A (2007). „Kit: molecule of interest for the diagnosis and treatment of mastocytosis and other neoplastic disorders”. Current cancer drug targets 7 (5): 492–503. DOI:10.2174/156800907781386614. PMID 17691909.
- Giebel LB, Strunk KM, Holmes SA, Spritz RA (1992). „Organization and nucleotide sequence of the human KIT (mast/stem cell growth factor receptor) proto-oncogene”. Oncogene 7 (11): 2207–17. PMID 1279499.
- Spritz RA, Droetto S, Fukushima Y (1992). „Deletion of the KIT and PDGFRA genes in a patient with piebaldism”. Am. J. Med. Genet. 44 (4): 492–5. DOI:10.1002/ajmg.1320440422. PMID 1279971.
- Spritz RA, Giebel LB, Holmes SA (1992). „Dominant negative and loss of function mutations of the c-kit (mast/stem cell growth factor receptor) proto-oncogene in human piebaldism”. Am. J. Hum. Genet. 50 (2): 261–9. PMC 1682440. PMID 1370874.
- Duronio V, Welham MJ, Abraham S, et al. (1992). „p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein”. Proc. Natl. Acad. Sci. U.S.A. 89 (5): 1587–91. DOI:10.1073/pnas.89.5.1587. PMC 48497. PMID 1371879.
- André C, Martin E, Cornu F, et al. (1992). „Genomic organization of the human c-kit gene: evolution of the receptor tyrosine kinase subclass III”. Oncogene 7 (4): 685–91. PMID 1373482.
- Lev S, Yarden Y, Givol D (1992). „A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses”. J. Biol. Chem. 267 (15): 10866–73. PMID 1375232.
- Fleischman RA (1992). „Human piebald trait resulting from a dominant negative mutant allele of the c-kit membrane receptor gene”. J. Clin. Invest. 89 (6): 1713–7. DOI:10.1172/JCI115772. PMC 295855. PMID 1376329.
- Vandenbark GR, deCastro CM, Taylor H, et al. (1992). „Cloning and structural analysis of the human c-kit gene”. Oncogene 7 (7): 1259–66. PMID 1377810.
- Alai M, Mui AL, Cutler RL, et al. (1992). „Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells”. J. Biol. Chem. 267 (25): 18021–5. PMID 1381360.
- Ashman LK, Cambareri AC, To LB, et al. (1991). „Expression of the YB5.B8 antigen (c-kit proto-oncogene product) in normal human bone marrow”. Blood 78 (1): 30–7. PMID 1712644.
Povezano
Vanjske veze
- MeSH Proto-Oncogene+Proteins+c-kit
- C-kit receptor Arhivirano 2009-05-10 na Wayback Machine-u
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