DUTP difosfataza
DUTP difosfataza | |||||||||
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Trimer DUTP difosfataze (čovjek) | |||||||||
Identifikatori | |||||||||
EC broj | 3.6.1.23 | ||||||||
CAS broj | 37289-34-2 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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DUTP difosfataza (EC 3.6.1.23, dezoksiuridin-trifosfataza, dUTPaza, dUTP pirofosfataza, dezoksiuridin 5'-trifosfatna nukleotidohidrolaza, desoksiuridinska 5'-trifosfataza) je enzim sa sistematskim imenom dUTP nukleotidohidrolaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- dUTP + H2O dUMP + difosfat
Reference
- ↑ Bertani, L.E., Häggmark, A. and Reichard, P. (1963). „Enzymatic synthesis of deoxyribonucleotides. II. Formation and interconversion of deoxyuridine phosphates”. J. Biol. Chem. 238: 3407-3413. PMID 14085395.
- ↑ Giroir, L.E. and Deutsch, W.A. (1987). „Drosophila deoxyuridine triphosphatase. Purification and characterization”. J. Biol. Chem. 262: 130-134. PMID 3025197.
- ↑ Greenberg, G.R. and Somerville, R.L. (1962). „Deoxyuridylate kinase activity and deoxyuridinetriphosphatase in Escherichia coli”. Proc. Natl. Acad. Sci. USA 48: 247-257. PMID 13901467.
- ↑ Grindey, G.B. and Nichol, C.A. (1971). „Mammalian deoxyuridine 5′-triphosphate pyrophosphatase”. Biochim. Biophys. Acta 240: 180-183. PMID 5105331.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Spoljašnje veze
- MeSH DUTP+diphosphatase
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6