FZD3
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Uvojiti receptor 3 | |||||||||||
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Identifikatori | |||||||||||
Simboli | FZD3; Fz-3 | ||||||||||
Vanjski ID | OMIM: 606143 MGI: 108476 HomoloGene: 23004 IUPHAR: FZD3 GeneCards: FZD3 Gene | ||||||||||
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Pregled RNK izražavanja | |||||||||||
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Ortolozi | |||||||||||
Vrsta | Čovek | Miš | |||||||||
Entrez | 7976 | 14365 | |||||||||
Ensembl | ENSG00000104290 | ENSMUSG00000007989 | |||||||||
UniProt | A8K615 | Q61086 | |||||||||
RefSeq (mRNA) | NM_017412.3 | NM_021458.2 | |||||||||
RefSeq (protein) | NP_059108.1 | NP_067433.1 | |||||||||
Lokacija (UCSC) | Chr 8: 28.35 - 28.43 Mb | Chr 14: 65.82 - 65.88 Mb | |||||||||
PubMed pretraga | [1] | [2] |
Uvojiti-3 je protein koji je kod ljudi kodiran FZD3 genom.[1][2][3]
Članovi familije 'uvojitih' proteina su 7-transmembranski receptori za Wnt signalne proteine. FZD3 protein sadrži signalni peptid, cisteinom bogati domen u N-terminalnom ekstracelularnom regionu, 7 transmembranski domen, i C-terminalni PDZ vezujući motiv. FZD3 transkript je izražen u različitim tkivima. Funkcija ovog proteina nije poznata. Postoje izvesne indikacije da učestvuje u razvoju folikula dlake kod sisara.[3]
Reference
- ↑ Kirikoshi H, Koike J, Sagara N, Saitoh T, Tokuhara M, Tanaka K, Sekihara H, Hirai M, Katoh M (Jun 2000). „Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21”. Biochem Biophys Res Commun 271 (1): 8–14. DOI:10.1006/bbrc.2000.2578. PMID 10777673.
- ↑ Sala CF, Formenti E, Terstappen GC, Caricasole A (Jul 2000). „Identification, gene structure, and expression of human frizzled-3 (FZD3)”. Biochem Biophys Res Commun 273 (1): 27–34. DOI:10.1006/bbrc.2000.2882. PMID 10873558.
- ↑ 3,0 3,1 „Entrez Gene: FZD3 frizzled homolog 3 (Drosophila)”.
Literatura
- Katoh M (2002). „GIPC gene family (Review).”. Int. J. Mol. Med. 9 (6): 585–9. PMID 12011974.
- Finch PW, He X, Kelley MJ, et al. (1997). „Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.”. Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. DOI:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.
- Wright M, Aikawa M, Szeto W, Papkoff J (1999). „Identification of a Wnt-responsive signal transduction pathway in primary endothelial cells.”. Biochem. Biophys. Res. Commun. 263 (2): 384–8. DOI:10.1006/bbrc.1999.1344. PMID 10491302.
- Hung BS, Wang XQ, Cam GR, Rothnagel JA (2001). „Characterization of mouse Frizzled-3 expression in hair follicle development and identification of the human homolog in keratinocytes.”. J. Invest. Dermatol. 116 (6): 940–6. DOI:10.1046/j.1523-1747.2001.01336.x. PMID 11407985.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Katsu T, Ujike H, Nakano T, et al. (2004). „The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia.”. Neurosci. Lett. 353 (1): 53–6. DOI:10.1016/j.neulet.2003.09.017. PMID 14642436.
- Zhang Y, Yu X, Yuan Y, et al. (2005). „Positive association of the human frizzled 3 (FZD3) gene haplotype with schizophrenia in Chinese Han population.”. Am. J. Med. Genet. B Neuropsychiatr. Genet. 129 (1): 16–9. DOI:10.1002/ajmg.b.30076. PMID 15274031.
- Zhang Z, Henzel WJ (2005). „Signal peptide prediction based on analysis of experimentally verified cleavage sites.”. Protein Sci. 13 (10): 2819–24. DOI:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
- Omoto S, Hayashi T, Kitahara K, et al. (2004). „Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).”. Ophthalmic Genet. 25 (2): 81–90. DOI:10.1080/13816810490514270. PMID 15370539.
- Hashimoto R, Suzuki T, Iwata N, et al. (2005). „Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders.”. Journal of neural transmission (Vienna, Austria : 1996) 112 (2): 303–7. DOI:10.1007/s00702-004-0264-2. PMID 15657645.
Povezano
Spoljašnje veze
- „Frizzled Receptors: FZD3”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2014-09-03.
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Drugi | Moždano specifični angiogenezni inhibitor (1, 2, 3) • Cadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2) |
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glutamat / feromon
Drugi |
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Frizzled / Zaglađeni
Uvojiti | |
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Zaglađeni |
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)