Fosforibozilaminoimidazolna karboksilaza
Fosforibozilaminoimidazolna karboksilaza | |||||||||
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Fosforibozilaminoimidazolna karboksilaza oktamer, Human | |||||||||
Identifikatori | |||||||||
EC broj | 4.1.1.21 | ||||||||
CAS broj | 2605007 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Fosforibozilaminoimidazolna karboksilaza (EC 4.1.1.21, 5-fosforibozil-5-aminoimidazolna karboksilaza, 5-amino-1-ribozilimidazol 5-fosfatna karboksilaza, AIR karboksilaza, 1-(5-fosforibozil)-5-amino-4-imidazolkarboksilatna karboksi-lijaza, ADE2, klasa II PurE, 5-amino-1-(5-fosfo-D-ribozil)imidazol-4-karboksilatna karboksi-lijaza) je enzim sa sistematskim imenom 5-amino-1-(5-fosfo-D-ribozil)imidazol-4-karboksilat karboksi-lijaza (formira 5-amino-1-(5-fosfo-D-ribozil)imidazol).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 5-amino-1-(5-fosfo-D-ribozil)imidazol-4-karboksilat 5-amino-1-(5-fosfo-D-ribozil)imidazol + CO2
Ova reakcija se odvija u kičmenjacima tokom purinske biosinteza.
Reference
- ↑ Lukens, L.N. and Buchanan, J.M. (1959). „Biosynthesis of purines. XXIV. The enzymatic synthesis of 5-amino-1-ribosyl-4-imidazolecarboxylic acid 5′-phosphate from 5-amino-1-ribosylimidazole 5′-phosphate and carbon dioxide”. J. Biol. Chem. 234: 1799-1805. PMID 13672967.
- ↑ Firestine, S.M., Poon, S.W., Mueller, E.J., Stubbe, J. and Davisson, V.J. (1994). „Reactions catalyzed by 5-aminoimidazole ribonucleotide carboxylases from Escherichia coli and Gallus gallus: a case for divergent catalytic mechanisms”. Biochemistry 33: 11927-11934. PMID 7918411.
- ↑ Firestine, S.M., Misialek, S., Toffaletti, D.L., Klem, T.J., Perfect, J.R. and Davisson, V.J. (1998). „Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis”. Arch. Biochem. Biophys. 351: 123-134. PMID 9500840.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Spoljašnje veze
- MeSH Phosphoribosylaminoimidazole+carboxylase
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6