Histamin trifluorometil toluidid
Histamin trifluorometil toluidid | |||
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IUPAC ime |
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Drugi nazivi | HTMT | ||
Identifikacija | |||
CAS registarski broj | 103827-16-3 ![]() | ||
PubChem[1][2] | 124846 | ||
ChemSpider[3] | 111155 ![]() | ||
IUPHAR ligand | 1273 | ||
Jmol-3D slike | Slika 1 | ||
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Svojstva | |||
Molekulska formula | C19H25F3N4O | ||
Molarna masa | 382,42321 | ||
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala | |||
Infobox references |
Histamin trifluorometil toluidid (HTMT) je mešoviti H1/H2 histaminski agonist koji je znatno potentniji od samog histamina.[4] On isto tako proizvodi dodatna dejstva koji su nezavisna od histaminskih receptora.[5][6]
Reference
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Whyment AD, Blanks AM, Lee K, Renaud LP, Spanswick D. Histamine excites neonatal rat sympathetic preganglionic neurons in vitro via activation of H1 receptors. Journal of Neurophysiology. 2006 Apr;95(4):2492-500. PMID 16354729
- ↑ Qiu R, Melmon KL, Khan MM. Effects of histamine-trifluoromethyl-toluidide derivative (HTMT) on intracellular calcium in human lymphocytes. Journal of Pharmacology and Experimental Therapeutics. 1990 Jun;253(3):1245-52. PMID 2359026
- ↑ Kim DC, Lee SY, Jun DJ, Kim SH, Lee JH, Hur EM, Baek NI, Kim KT. Inhibition of store-operated calcium entry-mediated superoxide generation by histamine trifluoromethyltoluide independent of histamine receptors. Biochemical Pharmacology. 2005 Nov 25;70(11):1613-22. PMID 16219299
Spoljašnje veze
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Inhibitori: Aminoguanidin |
Histamin; Prekursori: L-Histidin; Kofaktori: Vitamin B6 |