Histaminski H1 receptor
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Histamine receptor H1 | |||||||||||
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![]() Histaminski H1 receptor u kompleksu sa doksepinom (3RZE) | |||||||||||
Dostupne strukture | |||||||||||
3RZE | |||||||||||
Identifikatori | |||||||||||
Simboli | HRH1; H1-R; hisH1 | ||||||||||
Vanjski ID | OMIM: 600167 MGI: 107619 HomoloGene: 668 IUPHAR: H1 GeneCards: HRH1 Gene | ||||||||||
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Pregled RNK izražavanja | |||||||||||
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podaci | |||||||||||
Ortolozi | |||||||||||
Vrsta | Čovek | Miš | |||||||||
Entrez | 3269 | 15465 | |||||||||
Ensembl | ENSG00000196639 | ENSMUSG00000053004 | |||||||||
UniProt | P35367 | P70174 | |||||||||
RefSeq (mRNA) | NM_000861.3 | NM_001252642.1 | |||||||||
RefSeq (protein) | NP_000852.1 | NP_001239571.1 | |||||||||
Lokacija (UCSC) | Chr 3: 11.18 - 11.31 Mb | Chr 6: 114.35 - 114.43 Mb | |||||||||
PubMed pretraga | [1] | [2] |
H1 receptor je histaminski receptor iz familije rodopsinu sličnih G protein spregnutih receptora. Ovaj receptor, koji aktivira biogeni amin histamin, je izražen širom tela, u glatkim mišićima, vaskularnim endotelnim ćelijama, u srcu, i u centralnom nervnom sistemu. H1 receptor je spregnut sa intracelularnim G proteinom (Gq) koji aktivira signalni put fosfolipaze C i fosfatidilinozitola (PIP2). Antihistamini koji deluju na ovaj receptor se koriste kao lekovi protiv alergije. Kristalna struktura receptora je određena.[1]
Reference
- ↑ Tatsuro Shimamura, Mitsunori Shiroishi, Simone Weyand, Hirokazu Tsujimoto, Graeme Winter, Vsevolod Katritch, Ruben Abagyan, Vadim Cherezov, Wei Liu, Gye Won Han, Takuya Kobayashi, Raymond C. Stevens & So Iwata (July 2011). „Structure of the human histamine H1 receptor complex with doxepin”. Nature 475 (7354): 65–70. DOI:10.1038/nature10236. PMID 21697825.
Literatura
- Mitsuchashi M, Payan DG (1989). „Molecular and cellular analysis of histamine H1 receptors on cultured smooth muscle cells.”. J. Cell. Biochem. 40 (2): 183–92. DOI:10.1002/jcb.240400207. PMID 2670975.
- Braman SS (1987). „Histamine receptors in the lung.”. N Engl Reg Allergy Proc 8 (2): 116–20. DOI:10.2500/108854187778994446. PMID 2886904.
- Hill SJ, Ganellin CR, Timmerman H, et al. (1997). „International Union of Pharmacology. XIII. Classification of histamine receptors.”. Pharmacol. Rev. 49 (3): 253–78. PMID 9311023.
- Holden CA, Chan SC, Norris S, Hanifin JM (1988). „Histamine induced elevation of cyclic AMP phosphodiesterase activity in human monocytes.”. Agents Actions 22 (1–2): 36–42. DOI:10.1007/BF01968814. PMID 2891264.
- Moguilevsky N, Varsalona F, Noyer M, et al. (1994). „Stable expression of human H1-histamine-receptor cDNA in Chinese hamster ovary cells. Pharmacological characterisation of the protein, tissue distribution of messenger RNA and chromosomal localisation of the gene”. Eur. J. Biochem. 224 (2): 489–95. DOI:10.1111/j.1432-1033.1994.00489.x. PMID 7925364.
- Fukui H, Fujimoto K, Mizuguchi H, et al. (1994). „Molecular cloning of the human histamine H1 receptor gene”. Biochem. Biophys. Res. Commun. 201 (2): 894–901. DOI:10.1006/bbrc.1994.1786. PMID 8003029.
- Le Coniat M, Traiffort E, Ruat M, et al. (1994). „Chromosomal localization of the human histamine H1-receptor gene”. Hum. Genet. 94 (2): 186–8. PMID 8045566.
- De Backer MD, Gommeren W, Moereels H, et al. (1994). „Genomic cloning, heterologous expression and pharmacological characterization of a human histamine H1 receptor”. Biochem. Biophys. Res. Commun. 197 (3): 1601–8. DOI:10.1006/bbrc.1993.2662. PMID 8280179.
- Hishinuma S, Young JM (1996). „Characteristics of the binding of [3H-mepyramine to intact human U373 MG astrocytoma cells: evidence for histamine-induced H1-receptor internalisation”]. Br. J. Pharmacol. 116 (6): 2715–23. PMC 1909113. PMID 8590995.
- Max SI, Chowdhury BA, Fraser CM (1996). „Sequence analysis of the 5'-untranslated region of the human H1 histamine receptor-encoding gene”. Gene 171 (2): 309–10. DOI:10.1016/0378-1119(96)00036-4. PMID 8666296.
- De Backer MD, Loonen I, Verhasselt P, et al. (1998). „Structure of the human histamine H1 receptor gene”. Biochem. J. 335 (3): 663–70. PMC 1219830. PMID 9794809.
- Horváth BV, Szalai C, Mándi Y, et al. (1999). „Histamine and histamine-receptor antagonists modify gene expression and biosynthesis of interferon gamma in peripheral human blood mononuclear cells and in CD19-depleted cell subsets”. Immunol. Lett. 70 (2): 95–9. DOI:10.1016/S0165-2478(99)00126-1. PMID 10569698.
- Wang KY, Arima N, Higuchi S, et al. (2000). „Switch of histamine receptor expression from H2 to H1 during differentiation of monocytes into macrophages”. FEBS Lett. 473 (3): 345–8. DOI:10.1016/S0014-5793(00)01560-X. PMID 10818238.
- Oda T, Morikawa N, Saito Y, et al. (2001). „Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes”. J. Biol. Chem. 275 (47): 36781–6. DOI:10.1074/jbc.M006480200. PMID 10973974.
- Brew OB, Sullivan MH (2002). „Localisation of mRNAs for diamine oxidase and histamine receptors H1 and H2, at the feto-maternal interface of human pregnancy”. Inflamm. Res. 50 (9): 449–52. DOI:10.1007/PL00000269. PMID 11603849.
- Gutzmer R, Langer K, Lisewski M, et al. (2002). „Expression and function of histamine receptors 1 and 2 on human monocyte-derived dendritic cells”. J. Allergy Clin. Immunol. 109 (3): 524–31. DOI:10.1067/mai.2002.121944. PMID 11898002.
- Idzko M, la Sala A, Ferrari D, et al. (2002). „Expression and function of histamine receptors in human monocyte-derived dendritic cells”. J. Allergy Clin. Immunol. 109 (5): 839–46. DOI:10.1067/mai.2002.124044. PMID 11994709.
Povezano
- Antihistaminik – antagonist H1 receptora
Spoljašnje veze
- „Histamine Receptors: H1”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.
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Drugi | Moždano specifični angiogenezni inhibitor (1, 2, 3) • Cadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2) |
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glutamat / feromon
Drugi |
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Frizzled / Zaglađeni
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Zaglađeni |
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)