INHBC

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Inhibin, beta C
Identifikatori
SimboliINHBC; IHBC
Vanjski IDOMIM: 601233 MGI: 105932 HomoloGene: 21142 GeneCards: INHBC Gene
Ontologija gena
Molekularna funkcija • transformirajući faktor rasta beta receptorskog vezivanja
• hormonska aktivnost
• aktivnost faktora rasta
Celularna komponenta • ekstracelularni region
Biološki proces • razviće
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez362616325
EnsemblENSG00000175189ENSMUSG00000025405
UniProtP55103P55104
RefSeq (mRNA)NM_005538.2NM_010565.3
RefSeq (protein)NP_005529.1NP_034695.1
Lokacija (UCSC)Chr 12:
57.83 - 57.85 Mb		Chr 10:
127.36 - 127.37 Mb
PubMed pretraga[1][2]

Inhibin beta C lanac je protein koji je kod ljudi kodiran INHBC genom.[1][2]

Ovaj gen protein koji je član TGF-beta familije. Ova podjedinica formira heterodimere sa beta A i beta B podjedinicama. Inhibini i aktivini, takođe članovi TGF-beta familije, su hormoni sa suprotnim destvom koji učestvuju u hipotalamusnoj, hipofiznoj, i gonadalnoj hormonskoj sekreciji, kao i u razviću i diferencijaciji raznih ćelijskih tipova.[2]

Reference

  1. ↑ H tten G, Neidhardt H, Schneider C, Pohl J (Feb 1995). „Cloning of a new member of the TGF-beta family: a putative new activin beta C chain”. Biochem Biophys Res Commun 206 (2): 608–13. DOI:10.1006/bbrc.1995.1086. PMID 7826378. 
  2. ↑ 2,0 2,1 „Entrez Gene: INHBC inhibin, beta C”. 

Literatura

  • Bernard DJ, Chapman SC, Woodruff TK (2001). „Mechanisms of inhibin signal transduction.”. Recent Prog. Horm. Res. 56: 417–50. DOI:10.1210/rp.56.1.417. PMID 11237224. 
  • Mathews LS, Vale WW (1991). „Expression cloning of an activin receptor, a predicted transmembrane serine kinase.”. Cell 65 (6): 973–82. DOI:10.1016/0092-8674(91)90549-E. PMID 1646080. 
  • Schmitt J, Hötten G, Jenkins NA, et al. (1997). „Structure, chromosomal localization, and expression analysis of the mouse inhibin/activin beta C (Inhbc) gene.”. Genomics 32 (3): 358–66. DOI:10.1006/geno.1996.0130. PMID 8838799. 
  • Thomas TZ, Chapman SM, Hong W, et al. (1998). „Inhibins, activins, and follistatins: expression of mRNAs and cellular localization in tissues from men with benign prostatic hyperplasia.”. Prostate 34 (1): 34–43. DOI:10.1002/(SICI)1097-0045(19980101)34:1<34::AID-PROS5>3.0.CO;2-K. PMID 9428386. 
  • Mellor SL, Cranfield M, Ries R, et al. (2001). „Localization of activin beta(A)-, beta(B)-, and beta(C)-subunits in humanprostate and evidence for formation of new activin heterodimers of beta(C)-subunit.”. J. Clin. Endocrinol. Metab. 85 (12): 4851–8. DOI:10.1210/jc.85.12.4851. PMID 11134153. 
  • Casagrandi D, Bearfield C, Geary J, et al. (2003). „Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia.”. Mol. Hum. Reprod. 9 (4): 199–203. DOI:10.1093/molehr/gag029. PMID 12651901. 
  • Mellor SL, Ball EM, O'Connor AE, et al. (2003). „Activin betaC-subunit heterodimers provide a new mechanism of regulating activin levels in the prostate.”. Endocrinology 144 (10): 4410–9. DOI:10.1210/en.2003-0225. PMID 12960042. 
  • Ushiro Y, Hashimoto O, Seki M, et al. (2007). „Analysis of the function of activin betaC subunit using recombinant protein.”. J. Reprod. Dev. 52 (4): 487–95. DOI:10.1262/jrd.17110. PMID 16627954. 

Povezano

  • p
  • r
  • u
Endokrine
žlezde
Hipotalamusno-
hipofizni
Druge endokrine
žlezde
Neendokrine
žlezde

M: END

anat/phys/devp/horm/cell

noco(d)/cong/tumr, sysi/epon

proc, lek (A10/H1/H2/H3/H5)