P2RY1
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Purinski receptor P2Y, G-protein spregnuti, 1 | |||||||||||
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Identifikatori | |||||||||||
Simboli | P2RY1; P2Y1 | ||||||||||
Vanjski ID | OMIM: 601167 MGI: 105049 HomoloGene: 1926 IUPHAR: P2Y1 GeneCards: P2RY1 Gene | ||||||||||
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Pregled RNK izražavanja | |||||||||||
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Ortolozi | |||||||||||
Vrsta | Čovek | Miš | |||||||||
Entrez | 5028 | 18441 | |||||||||
Ensembl | ENSG00000169860 | ENSMUSG00000027765 | |||||||||
UniProt | P47900 | Q544J5 | |||||||||
RefSeq (mRNA) | NM_002563 | NM_008772 | |||||||||
RefSeq (protein) | NP_002554 | NP_032798 | |||||||||
Lokacija (UCSC) | Chr 3: 154.04 - 154.04 Mb | Chr 3: 61.09 - 61.1 Mb | |||||||||
PubMed pretraga | [1] | [2] |
P2Y purinoceptor 1 je protein koji kod je kod ljudi kodiran P2RY1 genom.[1]
Produkt ovog gena, P2Y1 pripada P2Y familiji GPCR receptora. Ta familija ima nekoliko receptorskih podtipova sa različitom farmakološkom selektivnošću. Ovaj receptor funkcioniše kao receptor za ekstracelularni ATP i ADP. U trombocitima ADP vezivanje dovodi do mobilizacije intracelularnih jona kalcijuma putem aktivacije fosfolipaze C, promene oblika trombocita, i verovatno doprinosi njihovoj agregaciji.[2]
Povezano
- P2Y receptor
Reference
- ↑ Ayyanathan K, Webbs TE, Sandhu AK, Athwal RS, Barnard EA, Kunapuli SP (Mar 1996). „Cloning and chromosomal localization of the human P2Y1 purinoceptor”. Biochem Biophys Res Commun 218 (3): 783–8. DOI:10.1006/bbrc.1996.0139. PMID 8579591.
- ↑ „Entrez Gene: P2RY1 purinergic receptor P2Y, G-protein coupled, 1”.
Literatura
- Janssens R, Communi D, Pirotton S, et al. (1996). „Cloning and tissue distribution of the human P2Y1 receptor.”. Biochem. Biophys. Res. Commun. 221 (3): 588–93. DOI:10.1006/bbrc.1996.0640. PMID 8630005.
- Léon C, Vial C, Cazenave JP, Gachet C (1996). „Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor.”. Gene 171 (2): 295–7. DOI:10.1016/0378-1119(96)00027-3. PMID 8666290.
- Léon C, Hechler B, Vial C, et al. (1997). „The P2Y1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells.”. FEBS Lett. 403 (1): 26–30. DOI:10.1016/S0014-5793(97)00022-7. PMID 9038354.
- Ayyanathan K, Naylor SL, Kunapuli SP (1997). „Structural characterization and fine chromosomal mapping of the human P2Y1 purinergic receptor gene (P2RY1).”. Somat. Cell Mol. Genet. 22 (5): 419–24. DOI:10.1007/BF02369897. PMID 9039850.
- Maier R, Glatz A, Mosbacher J, Bilbe G (1997). „Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues.”. Biochem. Biophys. Res. Commun. 237 (2): 297–302. DOI:10.1006/bbrc.1997.7135. PMID 9268704.
- Jin J, Daniel JL, Kunapuli SP (1998). „Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets.”. J. Biol. Chem. 273 (4): 2030–4. DOI:10.1074/jbc.273.4.2030. PMID 9442040.
- Hall RA, Ostedgaard LS, Premont RT, et al. (1998). „A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins.”. Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8496–501. DOI:10.1073/pnas.95.15.8496. PMC 21104. PMID 9671706.
- Sabala P, Czajkowski R, Przybyłek K, et al. (2001). „Two subtypes of G protein-coupled nucleotide receptors, P2Y(1) and P2Y(2) are involved in calcium signalling in glioma C6 cells.”. Br. J. Pharmacol. 132 (2): 393–402. DOI:10.1038/sj.bjp.0703843. PMC 1572584. PMID 11159687.
- Yoshioka K, Saitoh O, Nakata H (2001). „Heteromeric association creates a P2Y-like adenosine receptor.”. Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7617–22. DOI:10.1073/pnas.121587098. PMC 34717. PMID 11390975.
- James G, Butt AM (2001). „Changes in P2Y and P2X purinoceptors in reactive glia following axonal degeneration in the rat optic nerve.”. Neurosci. Lett. 312 (1): 33–6. DOI:10.1016/S0304-3940(01)02189-9. PMID 11578839.
- Moore DJ, Chambers JK, Wahlin JP, et al. (2001). „Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study.”. Biochim. Biophys. Acta 1521 (1-3): 107–19. PMID 11690642.
- Czajkowski R, Lei L, Sabała P, Barańska J (2002). „ADP-evoked phospholipase C stimulation and adenylyl cyclase inhibition in glioma C6 cells occur through two distinct nucleotide receptors, P2Y(1) and P2Y(12).”. FEBS Lett. 513 (2-3): 179–83. DOI:10.1016/S0014-5793(02)02255-X. PMID 11904146.
- Aktas B, Hönig-Liedl P, Walter U, Geiger J (2002). „Inhibition of platelet P2Y12 and alpha2A receptor signaling by cGMP-dependent protein kinase.”. Biochem. Pharmacol. 64 (3): 433–9. DOI:10.1016/S0006-2952(02)01113-9. PMID 12147294.
- Nurden P, Poujol C, Winckler J, et al. (2003). „Immunolocalization of P2Y1 and TPalpha receptors in platelets showed a major pool associated with the membranes of alpha -granules and the open canalicular system.”. Blood 101 (4): 1400–8. DOI:10.1182/blood-2002-02-0642. PMID 12393588.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Burrell HE, Bowler WB, Gallagher JA, Sharpe GR (2003). „Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors.”. J. Invest. Dermatol. 120 (3): 440–7. DOI:10.1046/j.1523-1747.2003.12050.x. PMID 12603858.
- Jagroop IA, Burnstock G, Mikhailidis DP (2003). „Both the ADP receptors P2Y1 and P2Y12, play a role in controlling shape change in human platelets.”. Platelets 14 (1): 15–20. DOI:10.1080/0953710021000062914. PMID 12623443.
- Greig AV, Linge C, Terenghi G, et al. (2003). „Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes.”. J. Invest. Dermatol. 120 (6): 1007–15. DOI:10.1046/j.1523-1747.2003.12261.x. PMID 12787128.
- Wang L, Ostberg O, Wihlborg AK, et al. (2003). „Quantification of ADP and ATP receptor expression in human platelets.”. J. Thromb. Haemost. 1 (2): 330–6. DOI:10.1046/j.1538-7836.2003.00070.x. PMID 12871508.
- „P2Y Receptors: P2Y1”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.
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Drugi | Moždano specifični angiogenezni inhibitor (1, 2, 3) • Cadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2) |
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glutamat / feromon
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Frizzled / Zaglađeni
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Zaglađeni |
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)