Prostaciklinski receptor
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Prostaglandinski I2 (prostaciklinski) receptor (IP1) | |||||||||||
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Identifikatori | |||||||||||
Simboli | PTGIR; MGC102830; PRIPR | ||||||||||
Vanjski ID | OMIM: 600022 MGI: 99535 HomoloGene: 7496 IUPHAR: IP1 GeneCards: PTGIR Gene | ||||||||||
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Pregled RNK izražavanja | |||||||||||
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podaci | |||||||||||
Ortolozi | |||||||||||
Vrsta | Čovek | Miš | |||||||||
Entrez | 5739 | 19222 | |||||||||
Ensembl | ENSG00000160013 | ENSMUSG00000043017 | |||||||||
UniProt | P43119 | Q3U4F1 | |||||||||
RefSeq (mRNA) | NM_000960 | NM_008967 | |||||||||
RefSeq (protein) | NP_000951 | NP_032993 | |||||||||
Lokacija (UCSC) | Chr 19: 51.82 - 51.82 Mb | Chr 7: 16.07 - 16.07 Mb | |||||||||
PubMed pretraga | [1] | [2] |
Prostaciklinski receptor (ili prostaglandinski I2 receptor, IP1) je receptor za prostaciklin.
On je član familije G-protein spregnutih receptora. Prostaciklin, glavni proizvod ciklooksigenaze u makrovaskularnom endotelu, uzrokuje potentnu vazodilataciju i inhibiciju agregacije trombocita putem vezivanja za ovaj receptor.[1]
Transdukcija
Prilikom vezivanja za molekul prostaciklina, receptor konformaciju i aktivira Gs, koji aktivira cAMP i povećava aktivnost proteinske kinaze A (PKA).
Reference
- ↑ „Entrez Gene: PTGIR prostaglandin I2 (prostacyclin) receptor (IP)”.
Literatura
- Coleman RA, Smith WL, Narumiya S (1994). „International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.”. Pharmacol. Rev. 46 (2): 205–29. PMID 7938166.
- Rauvala H, Peng HB (1997). „HB-GAM (heparin-binding growth-associated molecule) and heparin-type glycans in the development and plasticity of neuron-target contacts.”. Prog. Neurobiol. 52 (2): 127–44. DOI:10.1016/S0301-0082(97)00007-5. PMID 9185236.
- Smyth EM, FitzGerald GA (2003). „Human prostacyclin receptor.”. Vitam. Horm. 65: 149–65. DOI:10.1016/S0083-6729(02)65063-0. PMID 12481546.
- Boie Y, Rushmore TH, Darmon-Goodwin A, et al. (1994). „Cloning and expression of a cDNA for the human prostanoid IP receptor.”. J. Biol. Chem. 269 (16): 12173–8. PMID 7512962.
- Katsuyama M, Sugimoto Y, Namba T, et al. (1994). „Cloning and expression of a cDNA for the human prostacyclin receptor.”. FEBS Lett. 344 (1): 74–8. DOI:10.1016/0014-5793(94)00355-6. PMID 7514139.
- Ogawa Y, Tanaka I, Inoue M, et al. (1995). „Structural organization and chromosomal assignment of the human prostacyclin receptor gene.”. Genomics 27 (1): 142–8. DOI:10.1006/geno.1995.1016. PMID 7665161.
- Duncan AM, Anderson LL, Funk CD, et al. (1995). „Chromosomal localization of the human prostanoid receptor gene family.”. Genomics 25 (3): 740–2. DOI:10.1016/0888-7543(95)80022-E. PMID 7759114.
- Nakagawa O, Tanaka I, Usui T, et al. (1994). „Molecular cloning of human prostacyclin receptor cDNA and its gene expression in the cardiovascular system.”. Circulation 90 (4): 1643–7. PMID 7923647.
- Bonaldo MF, Lennon G, Soares MB (1997). „Normalization and subtraction: two approaches to facilitate gene discovery.”. Genome Res. 6 (9): 791–806. DOI:10.1101/gr.6.9.791. PMID 8889548.
- Sasaki Y, Takahashi T, Tanaka I, et al. (1997). „Expression of prostacyclin receptor in human megakaryocytes.”. Blood 90 (3): 1039–46. PMID 9242534.
- Fisch A, Tobusch K, Veit K, et al. (1997). „Prostacyclin receptor desensitization is a reversible phenomenon in human platelets.”. Circulation 96 (3): 756–60. PMID 9264479.
- Smyth EM, Li WH, FitzGerald GA (1998). „Phosphorylation of the prostacyclin receptor during homologous desensitization. A critical role for protein kinase c.”. J. Biol. Chem. 273 (36): 23258–66. DOI:10.1074/jbc.273.36.23258. PMID 9722557.
- Kömhoff M, Lesener B, Nakao K, et al. (1999). „Localization of the prostacyclin receptor in human kidney.”. Kidney Int. 54 (6): 1899–908. DOI:10.1046/j.1523-1755.1998.00213.x. PMID 9853255.
- Hayes JS, Lawler OA, Walsh MT, Kinsella BT (1999). „The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling.”. J. Biol. Chem. 274 (34): 23707–18. DOI:10.1074/jbc.274.34.23707. PMID 10446129.
- Smyth EM, Austin SC, Reilly MP, FitzGerald GA (2000). „Internalization and sequestration of the human prostacyclin receptor.”. J. Biol. Chem. 275 (41): 32037–45. DOI:10.1074/jbc.M003873200. PMID 10889200.
- Lawler OA, Miggin SM, Kinsella BT (2001). „Protein kinase A-mediated phosphorylation of serine 357 of the mouse prostacyclin receptor regulates its coupling to G(s)-, to G(i)-, and to G(q)-coupled effector signaling.”. J. Biol. Chem. 276 (36): 33596–607. DOI:10.1074/jbc.M104434200. PMID 11443126.
- Zhang Z, Austin SC, Smyth EM (2001). „Glycosylation of the human prostacyclin receptor: role in ligand binding and signal transduction.”. Mol. Pharmacol. 60 (3): 480–7. PMID 11502878.
- Fortier I, Patry C, Lora M, et al. (2001). „Immunohistochemical localization of the prostacyclin receptor (IP) human bone.”. Prostaglandins Leukot. Essent. Fatty Acids 65 (2): 79–83. DOI:10.1054/plef.2001.0292. PMID 11545623.
Povezano
Spoljašnje veze
- „Prostanoid Receptors: IP1”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.
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Drugi | Moždano specifični angiogenezni inhibitor (1, 2, 3) • Cadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2) |
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glutamat / feromon
Drugi |
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Frizzled / Zaglađeni
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Zaglađeni |
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)