Receptor glukagonu sličnog peptida 2
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Receptor glukagonu sličnog peptida 2 | |||||||||||
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Identifikatori | |||||||||||
Simbol | GLP2R | ||||||||||
Vanjski ID | OMIM: 603659 MGI: 2136733 HomoloGene: 3132 IUPHAR: GLP-2 GeneCards: GLP2R Gene | ||||||||||
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Pregled RNK izražavanja | |||||||||||
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podaci | |||||||||||
Ortolozi | |||||||||||
Vrsta | Čovek | Miš | |||||||||
Entrez | 9340 | 93896 | |||||||||
Ensembl | ENSG00000065325 | ENSMUSG00000049928 | |||||||||
UniProt | O95838 | Q5IXF8 | |||||||||
RefSeq (mRNA) | NM_004246.1 | NM_175681.3 | |||||||||
RefSeq (protein) | NP_004237.1 | NP_783612.2 | |||||||||
Lokacija (UCSC) | Chr 17: 9.73 - 9.8 Mb | Chr 11: 67.48 - 67.58 Mb | |||||||||
PubMed pretraga | [1] | [2] |
Gen za receptor glukagonu sličnog peptida 2 (GLP-2) se nalazi na hromozomu 17.[1]
Reference
- ↑ Brubaker PL, Drucker DJ (2002). „Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors”. Recept. Channels 8 (3–4): 179–88. DOI:10.1080/10606820213687. PMID 12529935. Arhivirano iz originala na datum 2006-10-20. Pristupljeno 2007-08-24.
Literatura
- Burrin DG, Petersen Y, Stoll B, Sangild P (2001). „Glucagon-like peptide 2: a nutrient-responsive gut growth factor”. J. Nutr. 131 (3): 709–12. PMID 11238747.
- Munroe DG, Gupta AK, Kooshesh F i dr.. (1999). „Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2”. Proc. Natl. Acad. Sci. U.S.A. 96 (4): 1569–73. DOI:10.1073/pnas.96.4.1569. PMC 15520. PMID 9990065.
- Yusta B, Huang L, Munroe D i dr.. (2000). „Enteroendocrine localization of GLP-2 receptor expression in humans and rodents”. Gastroenterology 119 (3): 744–55. DOI:10.1053/gast.2000.16489. PMID 10982769.
- Thulesen J, Knudsen LB, Hartmann B i dr.. (2002). „The truncated metabolite GLP-2 (3-33) interacts with the GLP-2 receptor as a partial agonist”. Regul. Pept. 103 (1): 9–15. DOI:10.1016/S0167-0115(01)00316-0. PMID 11738243.
- Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Koehler JA, Yusta B, Drucker DJ (2005). „The HeLa cell glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways”. Mol. Endocrinol. 19 (2): 459–73. DOI:10.1210/me.2004-0196. PMID 15471943.
- Ørskov C, Hartmann B, Poulsen SS i dr.. (2005). „GLP-2 stimulates colonic growth via KGF, released by subepithelial myofibroblasts with GLP-2 receptors”. Regul. Pept. 124 (1–3): 105–12. DOI:10.1016/j.regpep.2004.07.009. PMID 15544847.
- Mahon MJ, Shimada M (2005). „Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors”. FEBS Lett. 579 (3): 803–7. DOI:10.1016/j.febslet.2004.12.056. PMID 15670850.
- Estall JL, Koehler JA, Yusta B, Drucker DJ (2005). „The glucagon-like peptide-2 receptor C terminus modulates beta-arrestin-2 association but is dispensable for ligand-induced desensitization, endocytosis, and G-protein-dependent effector activation”. J. Biol. Chem. 280 (23): 22124–34. DOI:10.1074/jbc.M500078200. PMID 15817468.
- Guan X, Karpen HE, Stephens J i dr.. (2006). „GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow”. Gastroenterology 130 (1): 150–64. DOI:10.1053/j.gastro.2005.11.005. PMID 16401478.
- Sams A, Hastrup S, Andersen M, Thim L (2006). „Naturally occurring glucagon-like peptide-2 (GLP-2) receptors in human intestinal cell lines”. Eur. J. Pharmacol. 532 (1–2): 18–23. DOI:10.1016/j.ejphar.2005.12.001. PMID 16448646.
Povezano
Spoljašnje veze
- „Glucagon Receptor Family: GLP-2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2015-02-16.
- MeSH glucagon-like+peptide+receptor
- p
- r
- u
Drugi | Moždano specifični angiogenezni inhibitor (1, 2, 3) • Cadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2) |
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glutamat / feromon
Drugi |
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Frizzled / Zaglađeni
Uvojiti | |
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Zaglađeni |
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)