Receptor slobodnih masnih kiselina 1
edit |
Receptor slobodnih masnih kiselina 1 | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Identifikatori | |||||||||||
Simboli | FFAR1; FFA1R; GPCR40; GPR40 | ||||||||||
Vanjski ID | OMIM: 603820 MGI: 2684079 HomoloGene: 3876 IUPHAR: FFA1 GeneCards: FFAR1 Gene | ||||||||||
| |||||||||||
Ortolozi | |||||||||||
Vrsta | Čovek | Miš | |||||||||
Entrez | 2864 | 233081 | |||||||||
Ensembl | ENSG00000126266 | ENSMUSG00000044453 | |||||||||
UniProt | O14842 | Q76JU9 | |||||||||
RefSeq (mRNA) | NM_005303.2 | NM_194057.2 | |||||||||
RefSeq (protein) | NP_005294.1 | NP_918946.2 | |||||||||
Lokacija (UCSC) | Chr 19: 35.84 - 35.84 Mb | Chr 7: 31.65 - 31.65 Mb | |||||||||
PubMed pretraga | [1] | [2] |
Receptor slobodnih masnih kiselina 1 (FFA1) je G protein spregnuti receptor kodiran ljudskim genom FFAR1.[1] On je u znatnoj meri izražen u ćelijama pankreasa, a u manjoj meri u materici i mozgu.[2]
Reference
Literatura
- Brown AJ, Jupe S, Briscoe CP (2005). „A family of fatty acid binding receptors.”. DNA Cell Biol. 24 (1): 54–61. DOI:10.1089/dna.2005.24.54. PMID 15684720.
- Sawzdargo M, George SR, Nguyen T, et al. (1997). „A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.”. Biochem. Biophys. Res. Commun. 239 (2): 543–7. DOI:10.1006/bbrc.1997.7513. PMID 9344866.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Briscoe CP, Tadayyon M, Andrews JL, et al. (2003). „The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.”. J. Biol. Chem. 278 (13): 11303–11. DOI:10.1074/jbc.M211495200. PMID 12496284.
- Kotarsky K, Nilsson NE, Flodgren E, et al. (2003). „A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs.”. Biochem. Biophys. Res. Commun. 301 (2): 406–10. DOI:10.1016/S0006-291X(02)03064-4. PMID 12565875.
- Itoh Y, Kawamata Y, Harada M, et al. (2003). „Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.”. Nature 422 (6928): 173–6. DOI:10.1038/nature01478. PMID 12629551.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Hardy S, St-Onge GG, Joly E, et al. (2005). „Oleate promotes the proliferation of breast cancer cells via the G protein-coupled receptor GPR40.”. J. Biol. Chem. 280 (14): 13285–91. DOI:10.1074/jbc.M410922200. PMID 15695516.
- Ogawa T, Hirose H, Miyashita K, et al. (2005). „GPR40 gene Arg211His polymorphism may contribute to the variation of insulin secretory capacity in Japanese men.”. Metab. Clin. Exp. 54 (3): 296–9. DOI:10.1016/j.metabol.2004.09.008. PMID 15736105.
- Tomita T, Masuzaki H, Noguchi M, et al. (2006). „GPR40 gene expression in human pancreas and insulinoma.”. Biochem. Biophys. Res. Commun. 338 (4): 1788–90. DOI:10.1016/j.bbrc.2005.10.161. PMID 16289108.
- Tomita T, Masuzaki H, Iwakura H, et al. (2006). „Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumours in humans: evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretion.”. Diabetologia 49 (5): 962–8. DOI:10.1007/s00125-006-0193-8. PMID 16525841.
- Stoddart LA, Brown AJ, Milligan G (2007). „Uncovering the pharmacology of the G protein-coupled receptor GPR40: high apparent constitutive activity in guanosine 5'-O-(3-[35S]thio)triphosphate binding studies reflects binding of an endogenous agonist.”. Mol. Pharmacol. 71 (4): 994–1005. DOI:10.1124/mol.106.031534. PMID 17200419.
- Bartoov-Shifman R, Ridner G, Bahar K, et al. (2007). „Regulation of the gene encoding GPR40, a fatty acid receptor expressed selectively in pancreatic beta cells.”. J. Biol. Chem. 282 (32): 23561–71. DOI:10.1074/jbc.M702115200. PMID 17525159.
- Sum CS, Tikhonova IG, Neumann S, et al. (2007). „Identification of residues important for agonist recognition and activation in GPR40.”. J. Biol. Chem. 282 (40): 29248–55. DOI:10.1074/jbc.M705077200. PMID 17699519.
Povezano
Spoljašnje veze
- „Free Fatty Acid Receptors: FFA1”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-04.
- p
- r
- u
Drugi | Moždano specifični angiogenezni inhibitor (1, 2, 3) • Cadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2) |
---|
glutamat / feromon
Drugi |
---|
Frizzled / Zaglađeni
Uvojiti | |
---|---|
Zaglađeni |
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)