Undekaprenilna difosfataza

Undekaprenilna difosfataza
Identifikatori
EC broj 3.6.1.27
CAS broj 9077-80-9
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
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Undekaprenilna difosfataza (EC 3.6.1.27, C55-izoprenilna difosfataza, C55-izoprenilna pirofosfataza, izoprenilna pirofosfataza, undekaprenil pirofosfatna fosfataza, undekaprenil pirofosfatna pirofosfataza, UPP fosfataza, Und-PP pirofosfataza, UppP, BacA, undekaprenil-difosfatna fosfohidrolaza, undekaprenil-difosfataza) je enzim sa sistematskim imenom ditrans,oktacis-undekaprenil-difosfat fosfohidrolaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

ditrans,oktacis-undekaprenil difosfat + H2O ⇌ {\displaystyle \rightleftharpoons } ditrans,oktacis-undekaprenil fosfat + fosfat

Ovaj enzim je izolovan iz bakterija Micrococcus lysodeikticus, Escherichia coli i Bacillus subtilis.

Reference

  1. ↑ Goldman, R. and Strominger, J.L. (1972). „Purification and properties of C55-isoprenylpyrophosphate phosphatase from Micrococcus lysodeikticus”. J. Biol. Chem. 247: 5116-5122. PMID 4341539. 
  2. ↑ El Ghachi, M., Bouhss, A., Blanot, D. and Mengin-Lecreulx, D. (2004). „The bacA gene of Escherichia coli encodes an undecaprenyl pyrophosphate phosphatase activity”. J. Biol. Chem. 279: 30106-30113. PMID 15138271. 
  3. ↑ El Ghachi, M., Derbise, A., Bouhss, A. and Mengin-Lecreulx, D. (2005). „Identification of multiple genes encoding membrane proteins with undecaprenyl pyrophosphate phosphatase (UppP) activity in Escherichia coli”. J. Biol. Chem. 280: 18689-18695. PMID 15778224. 
  4. ↑ Bernard, R., El Ghachi, M., Mengin-Lecreulx, D., Chippaux, M. and Denizot, F. (2005). „BcrC from Bacillus subtilis acts as an undecaprenyl pyrophosphate phosphatase in bacitracin resistance”. J. Biol. Chem. 280: 28852-28857. PMID 15946938. 
  5. ↑ Tatar, L.D., Marolda, C.L., Polischuk, A.N., van Leeuwen, D. and Valvano, M.A. (2007). „An Escherichia coli undecaprenyl-pyrophosphate phosphatase implicated in undecaprenyl phosphate recycling”. Microbiology 153: 2518-2529. PMID 17660416. 
  6. ↑ Touze, T., Blanot, D. and Mengin-Lecreulx, D. (2008). „Substrate specificity and membrane topology of Escherichia coli PgpB, an undecaprenyl pyrophosphate phosphatase”. J. Biol. Chem. 283: 16573-16583. PMID 18411271. 

Literatura

  • Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
  • Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
  • Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
  • Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
  • Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
  • Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Spoljašnje veze

  • MeSH Undecaprenyl-diphosphate+phosphatase
  • p
  • r
  • u
TemeTipovi
EC1 Oksidoreduktaze/spisak  • EC2 Transferaze/spisak  • EC3 Hidrolaze/spisak  • EC4 Lijaze/spisak  • EC5 Izomeraze/spisak  • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6