Fenilalanin N-monooksigenaza
Fenilalanin N-monooksigenaza | |||||||||
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Identifikatori | |||||||||
EC broj | 1.14.13.124 | ||||||||
Baze podataka | |||||||||
IntEnz | IntEnz pregled | ||||||||
BRENDA | BRENDA pristup | ||||||||
ExPASy | NiceZyme pregled | ||||||||
KEGG | KEGG pristup | ||||||||
MetaCyc | metabolički put | ||||||||
PRIAM | profil | ||||||||
Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Fenilalanin N-monooksigenaza (EC 1.14.13.124, fenilalaninska N-hidroksilaza, CYP79A2) je enzim sa sistematskim imenom L-fenilalanin,NADPH:kiseonik oksidoreduktaza (N-hidroksilacija).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-fenilalanin + 2 O2 + 2 NADPH + 2 H+ (E)-fenilacetaldoksim + 2 NADP+ + CO2 + 3H2O (sveukupna reakcija)
- (1a) L-fenilalanin + O2 + NADPH + H+ N-hidroksi-L-fenilalanin + NADP+ + H2O
- (1b) N-hidroksi-L-fenilalanin + O2 + NADPH + H+ N,N-dihidroksi-L-fenilalanin + NADP+ +H2O
- (1c) N,N-dihidroksi-L-fenilalanin (E)-fenilacetaldoksim + CO2 +H2O
Ovaj enzim je hem-tiolatni protein (P-450). On katalizuje dve sukcesivne N-hidroksilacije L-fenilalanina.
Reference
- ^ Wittstock, U. & Halkier, B.A. (2000). „Cytochrome P450 CYP79A2 from Arabidopsis thaliana L. Catalyzes the conversion of L-phenylalanine to phenylacetaldoxime in the biosynthesis of benzylglucosinolate”. J. Biol. Chem. 275: 14659—14666. PMID 10799553.
Literatura
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
- Phenylalanine+N-monooxygenase на US National Library of Medicine Medical Subject Headings (MeSH)
- п
- р
- у
- EC1 Oksidoreduktaze /spisak
- EC2 Transferaze /spisak
- EC3 Hidrolaze /spisak
- EC4 Lijaze /spisak
- EC5 Izomeraze /spisak
- EC6 Ligaze /spisak
- B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6