GNA11

Guanin nukleotid-vezujući protein (G protein), alfa 11 (Gq klasa)
Identifikatori
Simboli GNA11; GNA-11
Vanjski ID OMIM: 139313 MGI: 95766 HomoloGene: 20474 GeneCards: GNA11 Gene
Ontologija gena
Molekularna funkcija vezivanje nukleotida
motorna aktivnost
aktivnost GTPaze
aktivnost prenosnika signala
GTP vezivanje
Celularna komponenta citoplazma
membrana plazme
kompleks miozina
Biološki proces skeletalni razvoj
regulacija akcionog potencijala
proteinska ADP-ribozilacija
prenos signala
signalni put G-protein spregnutog receptora
razvoj srca
regulacija melanocitne diferencijacije
pigmentacija tokom razvoja
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 2767 14672
Ensembl ENSG00000088256 ENSMUSG00000034781
UniProt P29992 Q3UPA1
RefSeq (mRNA) NM_002067 NM_010301
RefSeq (protein) NP_002058 NP_034431
Lokacija (UCSC) Chr 19:
3.05 - 3.07 Mb
Chr 10:
80.93 - 80.95 Mb
PubMed pretraga [1] [2]

GNA11, Guanin nukleotid-vezujući protein alfa 11, je protein koji je kod ljudi kodiran GNA11 genom.[1][2]


Vidi još

  • Gq alfa podjedinica

Референце

  1. ^ TM, Wilkie; DJ, Gilbert; AS, Olsen; XN, Chen; TT, Amatruda; JR, Korenberg; BJ, Trask; de Jong P; RR, Reed; Simon MI; et al. (1993). „Evolution of the mammalian G protein alpha subunit multigene family”. Nat Genet. 1 (2): 85—91. PMID 1302014. doi:10.1038/ng0592-85. CS1 одржавање: Експлицитна употреба et al. (веза)
  2. ^ „Entrez Gene: GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)”. 

Dodatna literatura

  • JR, Raymond; YV, Mukhin; A, Gelasco; et al. (2002). „Multiplicity of mechanisms of serotonin receptor signal transduction.”. Pharmacol. Ther. 92 (2-3): 179—212. PMID 11916537. doi:10.1016/S0163-7258(01)00169-3. CS1 одржавање: Експлицитна употреба et al. (веза)
  • Jiang M, Pandey S, Tran VT, Fong HK (1991). „Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells.”. Proc. Natl. Acad. Sci. U.S.A. 88 (9): 3907—11. PMC 51562 Слободан приступ. PMID 1902575. doi:10.1073/pnas.88.9.3907. 
  • Thomas CP, Dunn MJ, Mattera R (1996). „Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways.”. Biochem. J. 312 ( Pt 1): 151—8. PMC 1136238 Слободан приступ. PMID 7492305. 
  • Offermanns S, Simon MI (1995). „G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C.”. J. Biol. Chem. 270 (25): 15175—80. PMID 7797501. doi:10.1074/jbc.270.25.15175. 
  • Stanners J, Kabouridis PS, McGuire KL, Tsoukas CD (1996). „Interaction between G proteins and tyrosine kinases upon T cell receptor.CD3-mediated signaling.”. J. Biol. Chem. 270 (51): 30635—42. PMID 8530500. doi:10.1074/jbc.270.51.30635. 
  • KL, Laugwitz; A, Allgeier; S, Offermanns; et al. (1996). „The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families.”. Proc. Natl. Acad. Sci. U.S.A. 93 (1): 116—20. PMC 40189 Слободан приступ. PMID 8552586. doi:10.1073/pnas.93.1.116. CS1 одржавање: Експлицитна употреба et al. (веза)
  • JM, Launay; G, Birraux; D, Bondoux; et al. (1996). „Ras involvement in signal transduction by the serotonin 5-HT2B receptor.”. J. Biol. Chem. 271 (6): 3141—7. PMID 8621713. doi:10.1074/jbc.271.6.3141. CS1 одржавање: Експлицитна употреба et al. (веза)
  • Johnson GJ, Leis LA, Dunlop PC (1996). „Specificity of G alpha q and G alpha 11 gene expression in platelets and erythrocytes. Expressions of cellular differentiation and species differences.”. Biochem. J. 318 ( Pt 3): 1023—31. PMC 1217719 Слободан приступ. PMID 8836152. 
  • Kinsella BT, O'Mahony DJ, Fitzgerald GA (1997). „The human thromboxane A2 receptor alpha isoform (TP alpha) functionally couples to the G proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2 alpha.”. J. Pharmacol. Exp. Ther. 281 (2): 957—64. PMID 9152406. 
  • Wise A, Parenti M, Milligan G (1997). „Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane association.”. FEBS Lett. 407 (3): 257—60. PMID 9175863. doi:10.1016/S0014-5793(97)00300-1. 
  • Carrasco MP, Asbóth G, Phaneuf S, López Bernal A (1998). „Activation of the prostaglandin FP receptor in human granulosa cells.”. J. Reprod. Fertil. 111 (2): 309—17. PMID 9462300. 
  • Qian A, Wang W, Sanborn BM (1998). „Evidence for the involvement of several intracellular domains in the coupling of oxytocin receptor to G alpha(q/11).”. Cell. Signal. 10 (2): 101—5. PMID 9481484. doi:10.1016/S0898-6568(97)00097-1. 
  • NO, Dulin; A, Sorokin; E, Reed; et al. (1999). „RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to Galpha11.”. Mol. Cell. Biol. 19 (1): 714—23. PMC 83928 Слободан приступ. PMID 9858594. CS1 одржавање: Експлицитна употреба et al. (веза)
  • Hayes JS, Lawler OA, Walsh MT, Kinsella BT (1999). „The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling.”. J. Biol. Chem. 274 (34): 23707—18. PMID 10446129. doi:10.1074/jbc.274.34.23707. 
  • L, Brydon; F, Roka; L, Petit; et al. (2000). „Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins.”. Mol. Endocrinol. 13 (12): 2025—38. PMID 10598579. doi:10.1210/me.13.12.2025. CS1 одржавање: Експлицитна употреба et al. (веза)
  • S, Corbetta; G, Mantovani; A, Lania; et al. (2000). „Calcium-sensing receptor expression and signalling in human parathyroid adenomas and primary hyperplasia.”. Clin. Endocrinol. (Oxf). 52 (3): 339—48. PMID 10718832. doi:10.1046/j.1365-2265.2000.00933.x. CS1 одржавање: Експлицитна употреба et al. (веза)
  • Shraga-Levine Z, Sokolovsky M (2000). „Functional coupling of G proteins to endothelin receptors is ligand and receptor subtype specific.”. Cell. Mol. Neurobiol. 20 (3): 305—17. PMID 10789830. doi:10.1023/A:1007010125316. 
  • AbdAlla S, Lother H, Abdel-tawab AM, Quitterer U (2001). „The angiotensin II AT2 receptor is an AT1 receptor antagonist.”. J. Biol. Chem. 276 (43): 39721—6. PMID 11507095. doi:10.1074/jbc.M105253200. 
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3.6.1
Pirofosfataza (Neorganska, Tiamin) · Apiraza · Tiamin trifosfataza
3.6.23.6.3-4: ATPaza
3.6.3
Cu++ (3.6.3.4)
Menkes/ATP7A · Vilson/ATP7B
Ca+ (3.6.3.8)
SERCA (ATP2A1, ATP2A2, ATP2A3) · Membrana plazme (ATP2B1, ATP2B2, ATP2B3, ATP2B4) · SPCA (ATP2C1, ATP2C2)
Na+/K+ (3.6.3.9)
ATP1A1 · ATP1A2 · ATP1A3 · ATP1A4 · ATP1B1 · ATP1B2 · ATP1B3 · ATP1B4
H+/K+ (3.6.3.10)
ATP4A
Druge P-tip ATPaze
ATP8B1 · ATP10A · ATP11B · ATP12A · ATP13A2 · ATP13A3 ·
3.6.4
3.6.5: GTPaze
3.6.5.1: Heterotrimerni G protein
Gαs · Gαi (GNAI1, GNAI2, GNAI3· Gαq/11 (GNAQ, GNA11) · Gα12/13 (GNA12, GNA13· Transducin (GNAT1, GNAT2)
3.6.5.2: Male GTPaze > Ras superfamilija
Ras · Rab (Rab27) · Arf (Arf6) · Ran · Rheb · Ro familija (RhoA, RhoB, CDC42, Rac1) · Rap
3.6.5.3: GTPaza proteinske sinteze
Prokariotski (IF-2, EF-Tu, EF-G· Eukariotski
3.6.5.5-6: Polimerizacioni motori
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6