Neuropilin 1

Neuropilin 1
PDB prikaz baziran na 1kex​.
Dostupne strukture
1KEX​, 2QQI​, 2QQM​, 2QQN​, 3I97​, 4DEQ​
Identifikatori
Simboli NRP1; BDCA4; CD304; NP1; NRP; VEGF165R
Vanjski ID OMIM: 602069 MGI: 106206 HomoloGene: 2876 GeneCards: NRP1 Gene
Ontologija gena
Molekularna funkcija • aktivnost aktiviranog receptora vaskularnog endotelnog faktora rasta
• heparinsko vezivanje
• aktivnost koreceptora
Celularna komponenta • kompleks semaforinskog receptora
• ekstracelularni region
• citozol
Biološki proces • angiogeneza
• pozitivna regulacija endotelne ćelijske proliferacije
• ćelijska adhezija
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 8829 18186
Ensembl ENSG00000099250 ENSMUSG00000025810
UniProt O14786 P97333
RefSeq (mRNA) NM_001024628.2 NM_008737.2
RefSeq (protein) NP_001019799.1 NP_032763.2
Lokacija (UCSC) Chr 10:
33.47 - 33.63 Mb		 Chr 8:
128.36 - 128.51 Mb
PubMed pretraga [1] [2]

Neuropilin-1 je protein koji je kod ljudi kodiran NRP1 genom.[1][2][3] On je jedan od dva ljudska neuropilina.

NRP1 je za membranu vezan koreceptor receptora tirozinske kinaze za vaskularni endotelni faktor rasta (VEGF; MIM 192240) i članove familije semaforina (SEMA3A; MIM 603961). NRP1 ima više uloga u angiogenezi, navođenju aksona, ćelijskom opstanku, migraciji, i invaziji.[3]

Interakcije

Neuropilin 1 formira interakcije sa vaskularnim endotelnim faktorom rasta A.[1][4]

Reference

  1. ^ а б Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M (1998). „Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor”. Cell. 92 (6): 735—45. PMID 9529250. doi:10.1016/S0092-8674(00)81402-6. 
  2. ^ Chen H, Chedotal A, He Z, Goodman CS, Tessier-Lavigne M (1997). „Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III”. Neuron. 19 (3): 547—59. PMID 9331348. doi:10.1016/S0896-6273(00)80371-2. 
  3. ^ а б „Entrez Gene: NRP1 neuropilin 1”. 
  4. ^ Mamluk, Roni; Gechtman Ze'ev; et al. (2002). „Neuropilin-1 binds vascular endothelial growth factor 165, placenta growth factor-2, and heparin via its b1b2 domain”. J. Biol. Chem. United States. 277 (27): 24818—25. ISSN 0021-9258. PMID 11986311. doi:10.1074/jbc.M200730200. 

Literatura

  • Zachary I, Gliki G (2001). „Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family.”. Cardiovasc. Res. 49 (3): 568—81. PMID 11166270. doi:10.1016/S0008-6363(00)00268-6. 
  • He Z, Tessier-Lavigne M (1997). „Neuropilin is a receptor for the axonal chemorepellent Semaphorin III.”. Cell. 90 (4): 739—51. PMID 9288753. doi:10.1016/S0092-8674(00)80534-6. 
  • Giger RJ; Urquhart ER; Gillespie SK; et al. (1999). „Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity.”. Neuron. 21 (5): 1079—92. PMID 9856463. doi:10.1016/S0896-6273(00)80625-X. 
  • Chen H, He Z, Bagri A, Tessier-Lavigne M (1999). „Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins.”. Neuron. 21 (6): 1283—90. PMID 9883722. doi:10.1016/S0896-6273(00)80648-0. 
  • Takahashi T; Nakamura F; Jin Z; et al. (1999). „Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors.”. Nat. Neurosci. 1 (6): 487—93. PMID 10196546. doi:10.1038/2203. 
  • Rossignol M, Beggs AH, Pierce EA, Klagsbrun M (1999). „Human neuropilin-1 and neuropilin-2 map to 10p12 and 2q34, respectively.”. Genomics. 57 (3): 459—60. PMID 10329017. doi:10.1006/geno.1999.5790. 
  • Makinen T; Olofsson B; Karpanen T; et al. (1999). „Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1.”. J. Biol. Chem. 274 (30): 21217—22. PMID 10409677. doi:10.1074/jbc.274.30.21217. 
  • Cai H, Reed RR (1999). „Cloning and characterization of neuropilin-1-interacting protein: a PSD-95/Dlg/ZO-1 domain-containing protein that interacts with the cytoplasmic domain of neuropilin-1.”. J. Neurosci. 19 (15): 6519—27. PMID 10414980. 
  • Takahashi T; Fournier A; Nakamura F; et al. (1999). „Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors.”. Cell. 99 (1): 59—69. PMID 10520994. doi:10.1016/S0092-8674(00)80062-8. 
  • Tamagnone L; Artigiani S; Chen H; et al. (1999). „Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.”. Cell. 99 (1): 71—80. PMID 10520995. doi:10.1016/S0092-8674(00)80063-X. 
  • Gagnon ML; Bielenberg DR; Gechtman Z; et al. (2000). „Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: In vivo expression and antitumor activity.”. Proc. Natl. Acad. Sci. U.S.A. 97 (6): 2573—8. PMC 15970 Слободан приступ. PMID 10688880. doi:10.1073/pnas.040337597. 
  • Gluzman-Poltorak Z, Cohen T, Herzog Y, Neufeld G (2000). „Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected].”. J. Biol. Chem. 275 (24): 18040—5. PMID 10748121. doi:10.1074/jbc.M909259199. 
  • Fuh G, Garcia KC, de Vos AM (2000). „The interaction of neuropilin-1 with vascular endothelial growth factor and its receptor flt-1.”. J. Biol. Chem. 275 (35): 26690—5. PMID 10842181. doi:10.1074/jbc.M003955200. 
  • Rossignol M, Gagnon ML, Klagsbrun M (2001). „Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms.”. Genomics. 70 (2): 211—22. PMID 11112349. doi:10.1006/geno.2000.6381. 
  • Simpson JC; Wellenreuther R; Poustka A; et al. (2001). „Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.”. EMBO Rep. 1 (3): 287—92. PMC 1083732 Слободан приступ. PMID 11256614. doi:10.1093/embo-reports/kvd058. 
  • Whitaker GB, Limberg BJ, Rosenbaum JS (2001). „Vascular endothelial growth factor receptor-2 and neuropilin-1 form a receptor complex that is responsible for the differential signaling potency of VEGF(165) and VEGF(121).”. J. Biol. Chem. 276 (27): 25520—31. PMID 11333271. doi:10.1074/jbc.M102315200. 
  • Walter JW; North PE; Waner M; et al. (2002). „Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma.”. Genes Chromosomes Cancer. 33 (3): 295—303. PMID 11807987. doi:10.1002/gcc.10028. 
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PDB Galerija
  • 1kex​: Kristalna struktura b1 domena ljudskog neuropilin-1
    1kex​: Kristalna struktura b1 domena ljudskog neuropilin-1
  • 2orx​: Strukturna baza za vezivanje liganda i heparinom posredovanu aktivaciju neuropilina
    2orx​: Strukturna baza za vezivanje liganda i heparinom posredovanu aktivaciju neuropilina
  • 2orz​: Strukturna baza za vezivanje liganda i heparinom posredovanu aktivaciju neuropilina
    2orz​: Strukturna baza za vezivanje liganda i heparinom posredovanu aktivaciju neuropilina