PCCG-4
IUPAC ime | |
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(2S,1'S,2'S,3'R)-2-(2'karboksi-3'-fenilciklopropil)glicin | |
Identifikatori | |
ATC kod | none |
PubChem | CID 5311344 |
ChemSpider | 4470843 Y |
ChEMBL | CHEMBL39573 Y |
Hemijski podaci | |
Formula | C12H13NO4 |
Molarna masa | 235,235 g/mol |
SMILES
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InChI
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PCCG-4 je istraživački lek koji deluje kao selektivni antagonist za grupu II metabotropnih glutamatnih receptora (mGluR2/3), sa neznatnom selektivnošću za mGluR2. Ona nije dovoljna za razlikovanje mGluR2 i mGluR3 responsa. PCCG-4 se koristi u istraživanjima funkcije grupe II metabotropnih glutamatnih receptora.[1][2][3][4][5]
Reference
- ^ Pellicciari R, Marinozzi M, Natalini B, Costantino G, Luneia R, Giorgi G, Moroni F, Thomsen C (1996). „Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2'-carboxy-3'-phenylcyclopropyl)glycine. Focus on (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptors antagonist”. Journal of Medicinal Chemistry. 39 (11): 2259—69. PMID 8667369. doi:10.1021/jm960059+.
- ^ Thomsen C, Bruno V, Nicoletti F, Marinozzi M, Pellicciari R (1996). „(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a potent and selective antagonist of type 2 metabotropic glutamate receptors”. Molecular Pharmacology. 50 (1): 6—9. PMID 8700119.
- ^ Cozzi A, Attucci S, Peruginelli F, Marinozzi M, Luneia R, Pellicciari R, Moroni F (1997). „Type 2 metabotropic glutamate (mGlu) receptors tonically inhibit transmitter release in rat caudate nucleus: in vivo studies with (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a new potent and selective antagonist”. The European Journal of Neuroscience. 9 (7): 1350—5. PMID 9240392.
- ^ Ciccarelli R, Di Iorio P, Bruno V, Battaglia G, D'Alimonte I, D'Onofrio M, Nicoletti F, Caciagli F (1999). „Activation of A(1) adenosine or mGlu3 metabotropic glutamate receptors enhances the release of nerve growth factor and S-100beta protein from cultured astrocytes”. Glia. 27 (3): 275—81. PMID 10457374.
- ^ Vetter P, Garthwaite J, Batchelor AM (1999). „Regulation of synaptic transmission in the mossy fibre-granule cell pathway of rat cerebellum by metabotropic glutamate receptors”. Neuropharmacology. 38 (6): 805—15. PMID 10465684. doi:10.1016/S0028-3908(99)00003-9.
Spoljašnje veze
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Glutamatergični ligandi
Grupa I | Agonisti: Neselektivni: ACPD • DHPG • Kuiskualinska kiselina; mGlu1-selektivni: Ro01-6128 • Ro67-4853 • Ro67-7476 • VU-71; mGlu5-selektivni: ADX-47273 • CDPPB • CHPG • DFB • VU-1545 Antagonisti: Neselektivni: MCPG • NPS-2390; mGlu1-selektivni: BAY 36-7620 • CPCCOEt • LY-367,385 • LY-456,236; mGlu5-selektivni: DMeOB • Fenobam • LY-344,545 • MPEP • MTEP • SIB-1757 • SIB-1893 |
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Grupa II | Agonisti: Neselektivni: CBiPES • DCG-IV • Eglumegad • LY-379,268 • LY-404,039 • LY-487,379 • MGS-0028; mGlu2-selektivni: BINA • LY-566,332 Antagonisti: Neselektivni: APICA • EGLU • HYDIA • LY-307,452 • LY-341,495 • MCPG • MGS-0039; mGlu2-selektivni: PCCG-4; mGlu3-selektivni: CECXG; Negativni alosterni modulatori: RO4491533 |
Grupa III | Agonisti: Neselektivni: L-AP4; mGlu4-selektivni: PHCCC • VU-001,171 • VU-0155,041; mGlu7-selektivni: AMN082; mGlu8-selektivni: DCPG Antagonisti: Neselektivni: CPPG • MAP4 • MSOP • MPPG • MTPG • UBP-1112; mGlu7-selektivni: MMPIP |
transporta
EAAT | |
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vGluT |