Riboza-fosfat difosfokinaza

Identifikatori

EC broj

2.7.6.1

CAS broj

9015-83-2

Baze podataka

IntEnz

IntEnz pregled

BRENDA

BRENDA pristup

ExPASy

NiceZyme pregled

KEGG

KEGG pristup

MetaCyc

metabolički put

PRIAM

profil

Strukture PBP

RCSB PDB PDBe PDBj PDBsum

Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Riboza-fosfat difosfokinaza (EC 2.7.6.1, riboza-fosfatna pirofosfokinaza, PRPP sintetaza, fosforibozilpirofosfatna sintetaza, PPRibP sintetaza, PP-riboza P sintetaza, 5-fosforibozil-1-pirofosfatna sintetaza, 5-fosforibozna pirofosforilaza, 5-fosforibozil-alfa-1-pirofosfatna sintetaza, fosforibozil-difosfatna sintetaza, fosforibozilpirofosfatna sintaza, pirofosforibozilfosfatna sintetaza, ribofosfatna pirofosfokinaza, riboza-5-fosfatna pirofosfokinaza) je enzim sa sistematskim imenom ATP:D-riboza-5-fosfat difosfotransferaza.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + D-riboza 5-fosfat

\rightleftharpoons

AMP + 5-fosfo-alfa-D-riboza 1-difosfat

dATP takođe može da deluje kao donor.

Reference

^ Hughes, D.E. & Williamson, D.H. (1952). „Some properties of glutaminase of Clostridium welchii”. Biochem. J. 51: 45—55. PMID 14944530.
^ Hurlbert, R.B. & Reichard, P. (1955). „The conversion of orotic acid to uridine nucleotides in vitro”. Acta Chem. Scand. 9: 251—262.
^ Remy, C.N., Remy, W.T. and Buchanan, J.M. (1955). „Biosynthesis of the purines. VIII. Enzymatic synthesis and utilization of α-5-phosphoribosylpyrophosphate”. J. Biol. Chem. 217: 885—895. PMID 13271449. CS1 одржавање: Вишеструка имена: списак аутора (веза)
^ Switzer, R.L. (1969). „Regulation and mechanism of phosphoribosylpyrophosphate synthetase. I. Purification and properties of the enzyme from Salmonella typhimurium”. J. Biol. Chem. 244: 2854—2863. PMID 4306285.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Ribose-phosphate+diphosphokinase на US National Library of Medicine Medical Subject Headings (MeSH)

Enzimi

Teme

Tipovi

EC1 Oksidoreduktaze /spisak
EC2 Transferaze /spisak
EC3 Hidrolaze /spisak
EC4 Lijaze /spisak
EC5 Izomeraze /spisak
EC6 Ligaze /spisak

B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6