Vapreotid
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Klinički podaci | |
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Prodajno ime | Sanvar, Sanvar IR |
Drugs.com | Monografija |
Farmakokinetički podaci | |
Poluvreme eliminacije | 30 minuta |
Identifikatori | |
CAS broj | 103222-11-3 ![]() |
ATC kod | H01CB04 (WHO) |
PubChem | CID 23725064 |
DrugBank | DB04894 ![]() |
ChemSpider | 64425 ![]() |
Hemijski podaci | |
Formula | C57H70N12O9S2 |
Molarna masa | 1131,371 |
SMILES
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InChI
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Vapreotid je organsko jedinjenje, koje sadrži 57 atoma ugljenika i ima molekulsku masu od 1131,371 Da.[1][2][3][4][5][6][7][8][9]
Osobine
Osobina | Vrednost |
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Broj akceptora vodonika | 13 |
Broj donora vodonika | 13 |
Broj rotacionih veza | 18 |
Particioni koeficijent[10] (ALogP) | 3,2 |
Rastvorljivost[11] (logS, log(mol/L)) | -13,3 |
Polarna površina[12] (PSA, Å2) | 401,2 |
Reference
- ^ Sarr, M. G.; Pancreatic Surgery Group (2003). „The potent somatostatin analogue vapreotide does not decrease pancreas-specific complications after elective pancreatectomy: A prospective, multicenter, double-blinded, randomized, placebo-controlled trial”. Journal of the American College of Surgeons. 196 (4): 556—64; discussion 564—5; author reply 565. PMID 12691930. doi:10.1016/S1072-7515(03)00104-2.
- ^ „Vapreotide: BMY 41606, RC 160, Sanvar”. Drugs in R&D. 4 (5): 326—30. 2003. PMID 12952505. S2CID 241912168. doi:10.2165/00126839-200304050-00010.
- ^ Norman, P. (новембар 2000). „Vapreotide (Debipharm)”. Idrugs : The Investigational Drugs Journal. 3 (11): 1358—72. PMID 16047258. CS1 одржавање: Формат датума (веза)
- ^ Betoin, F.; Ardid, D.; Herbet, A.; Aumaitre, O.; Kemeny, J. L.; Duchene-Marullaz, P.; Lavarenne, J.; Eschalier, A. (април 1994). „Evidence for a central long-lasting antinociceptive effect of vapreotide, an analog of somatostatin, involving an opioidergic mechanism”. The Journal of Pharmacology and Experimental Therapeutics. 269 (1): 7—14. PMID 7909563. CS1 одржавање: Формат датума (веза)
- ^ Girard, P. M.; Goldschmidt, E.; Vittecoq, D.; Massip, P.; Gastiaburu, J.; Meyohas, M. C.; Coulaud, J. P.; Schally, A. V. (јул 1992). „Vapreotide, a somatostatin analogue, in cryptosporidiosis and other AIDS-related diarrhoeal diseases”. Aids (London, England). 6 (7): 715—8. PMID 1354449. S2CID 21204910. doi:10.1097/00002030-199207000-00015. CS1 одржавање: Формат датума (веза)}-
- ^ Stiefel, F.; Morant, R. (јануар 1993). „Vapreotide, a new somatostatin analogue in the palliative management of obstructive ileus in advanced cancer”. Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer. 1 (1): 57—8. PMID 7511473. S2CID 5672220. doi:10.1007/BF00326640. CS1 одржавање: Формат датума (веза)}-
- ^ Betoin, F.; Eschalier, A.; Duchene-Marullaz, P.; Lavarenne, J. (1994-01-31). „Seven-day antinociceptive effect of a sustained release vapreotide formulation”. NeuroReport. 5 (5): 642—4. PMID 7912964. doi:10.1097/00001756-199401000-00028. }-
- ^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709
. PMID 21059682. doi:10.1093/nar/gkq1126.
- ^ Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889
. PMID 18048412. doi:10.1093/nar/gkm958.
- ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
- ^ Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
- ^ Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.
Literatura
- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze
- Vapreotide
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