ABCC8

Tanımlayıcılar

Başka adlar

ABCC8

Dış kimlikler

OMIM: 600509 MGI: 1352629 HomoloGene: 68048 GeneCards: ABCC8

Gen yerleşimi (İnsan)

Krom.	11. Kromozom (insan)^[1]

Bant	11p15.1	Başlangıç	17,392,498 bç^[1]
Bant	11p15.1	Bitiş	17,476,894 bç^[1]

RNA ekspresyonu deseni

Daha çok ekspresyon verisi başvurusu

Gen ontolojisi
Moleküler işlevi	• nucleotide binding • transmembrane transporter binding • sulfonylurea receptor activity • ATPase activity • ATP binding • ATP-activated inward rectifier potassium channel activity • ATPase-coupled transmembrane transporter activity • GO:0001948, GO:0016582 protein bağlanması • potassium channel activity
Hücresel bileşeni	• integral component of membrane • membrane • Hücre zarı • inward rectifying potassium channel • Miyolem • mitokondri • synaptic vesicle membrane
Biyolojik süreci	• regulation of insulin secretion • potassium ion transport • GO:0072468 Sinyal transdüksiyonu • potassium ion transmembrane transport • transmembrane transport • cellular glucose homeostasis • female pregnancy • bellek • visual learning • response to pH • response to zinc ion • negative regulation of low-density lipoprotein particle clearance • negative regulation of angiogenesis • response to lipopolysaccharide • positive regulation of tumor necrosis factor production • response to insulin • positive regulation of potassium ion transport • negative regulation of insulin secretion • negative regulation of neurogenesis • negative regulation of glial cell proliferation • negative regulation of wound healing • negative regulation of neuroblast migration • cellular response to organic substance • positive regulation of uterine smooth muscle relaxation • positive regulation of voltage-gated potassium channel activity • positive regulation of tight junction disassembly • negative regulation of blood-brain barrier permeability
Kaynaklar:Amigo / QuickGO

Ortologlar

Türler

İnsan

Fare

Entrez


6833


20927

Ensembl


ENSG00000006071


ENSMUSG00000040136

UniProt


Q09428


n/a

RefSeq (mRNA)


NM_000352 NM_001287174 NM_001351295 NM_001351296 NM_001351297


NM_011510 NM_001357538

RefSeq (protein)


NP_000343 NP_001274103 NP_001338224 NP_001338225 NP_001338226


n/a

Yerleşim (UCSC)

Krom. 11: 17.39 – 17.48 Mb

n/a

PubMed araması

^[2]

^[3]

Vikiveri

İnsan'ı Gör/Düzenle

Fare'yi Gör/Düzenle

ATP bağlayıcı kaset taşıyıcı C alt ailesinin 8. üyesi, insanların 11. kromozomunda yer alan ABCC8 geni tarafından kodlanan bir proteindir.^[4]^[5]

Kaynakça

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000006071 - Ensembl, May 2017
^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine. Arşivlenmesi gereken bağlantıya sahip kaynak şablonu içeren maddeler (link)
^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine. Arşivlenmesi gereken bağlantıya sahip kaynak şablonu içeren maddeler (link)
^ Glaser B, Chiu KC, Anker R, Nestorowicz A, Landau H, Ben-Bassat H, ve diğerleri. (June 1994). "Familial hyperinsulinism maps to chromosome 11p14-15.1, 30 cM centromeric to the insulin gene". Nature Genetics. 7 (2). ss. 185-188. doi:10.1038/ng0694-185. PMID 7920639.
^ Thomas PM, Cote GJ, Wohllk N, Haddad B, Mathew PM, Rabl W, ve diğerleri. (April 1995). "Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy". Science. 268 (5209). ss. 426-429. Bibcode:1995Sci...268..426T. doi:10.1126/science.7716548. PMID 7716548.