Інсуліноподібний фактор росту 1 |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 1B9G, 1GZR, 1GZY, 1GZZ, 1H02, 1H59, 1IMX, 1PMX, 1TGR, 1WQJ, 2DSR, 2GF1, 3GF1, 3LRI, 1BQT, 4XSS | | |
Ідентифікатори |
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Символи | IGF1, IGF-I, IGF1A, IGFI, MGF, insulin like growth factor 1, IGF |
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Зовнішні ІД | OMIM: 147440 HomoloGene: 515 GeneCards: IGF1 |
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Пов'язані генетичні захворювання |
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growth delay due to insulin-like growth factor type 1 deficiency[1] |
Онтологія гена |
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Молекулярна функція | • hormone activity • insulin receptor binding • growth factor activity • integrin binding • GO:0001948, GO:0016582 protein binding • insulin-like growth factor receptor binding |
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Клітинна компонента | • extracellular region • exocytic vesicle • insulin-like growth factor binding protein complex • platelet alpha granule lumen • insulin-like growth factor ternary complex • alphav-beta3 integrin-IGF-1-IGF1R complex • клітинна мембрана • міжклітинний простір |
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Біологічний процес | • positive regulation of transcription regulatory region DNA binding • skeletal system development • positive regulation of glucose import • muscle organ development • positive regulation of Ras protein signal transduction • response to heat • positive regulation of cardiac muscle hypertrophy • positive regulation of smooth muscle cell migration • реплікація ДНК • positive regulation of insulin-like growth factor receptor signaling pathway • phosphatidylinositol 3-kinase signaling • positive regulation of DNA binding • Ras protein signal transduction • проліферація • positive regulation of mitotic nuclear division • positive regulation of trophectodermal cell proliferation • positive regulation of glycogen biosynthetic process • positive regulation of fibroblast proliferation • ERK1 and ERK2 cascade • negative regulation of extrinsic apoptotic signaling pathway • cell activation • negative regulation of oocyte development • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • bone mineralization involved in bone maturation • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of MAPK cascade • proteoglycan biosynthetic process • positive regulation of activated T cell proliferation • positive regulation of epithelial cell proliferation • negative regulation of release of cytochrome c from mitochondria • protein stabilization • myotube cell development • positive regulation of DNA replication • myoblast proliferation • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration • positive regulation of protein secretion • positive regulation of glycoprotein biosynthetic process • регуляція експресії генів • phosphatidylinositol-mediated signaling • positive regulation of smooth muscle cell proliferation • muscle hypertrophy • protein kinase B signaling • regulation of multicellular organism growth • positive regulation of cell migration • platelet degranulation • positive regulation of calcineurin-NFAT signaling cascade • positive regulation of phosphatidylinositol 3-kinase signaling • myoblast differentiation • glycolate metabolic process • positive regulation of glycolytic process • negative regulation of smooth muscle cell apoptotic process • GO:0072468 сигнальна трансдукція • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of cell growth involved in cardiac muscle cell development • positive regulation of cell population proliferation • positive regulation of osteoblast differentiation • activation of protein kinase B activity • insulin-like growth factor receptor signaling pathway • negative regulation of apoptotic process • positive regulation of tyrosine phosphorylation of STAT protein • regulation of signaling receptor activity • GO:1901313 positive regulation of gene expression • negative regulation of gene expression • cellular response to amyloid-beta • positive regulation of vascular associated smooth muscle cell proliferation • negative regulation of vascular associated smooth muscle cell apoptotic process • negative regulation of interleukin-1 beta production • negative regulation of tumor necrosis factor production • negative regulation of neuroinflammatory response • negative regulation of amyloid-beta formation |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | NM_000618 NM_001111283 NM_001111284 NM_001111285 |
| | NM_001082477 NM_001082478 NM_001082479 NM_178866 |
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RefSeq (білок) | | NP_000609 NP_001104753 NP_001104754 NP_001104755 |
| | NP_001075946 NP_001075947 NP_001075948 NP_849197 |
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Локус (UCSC) | Хр. 12: 102.4 – 102.48 Mb | н/д |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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