CRHR1 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/1/1c/6PB0_CRF1_receptor.png/250px-6PB0_CRF1_receptor.png) |
Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 4K5Y, 3EHU, 2L27, 3EHS, 3EHT, 4Z9G | | |
Ідентифікатори |
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Символи | CRHR1, CRF-R, CRF-R-1, CRF-R1, CRF1, CRFR-1, CRFR1, CRH-R-1, CRH-R1, CRH-R1h, CRHR, CRHR1L, CRHR1f, corticotropin releasing hormone receptor 1 |
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Зовнішні ІД | OMIM: 122561 MGI: 88498 HomoloGene: 20920 GeneCards: CRHR1 |
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Реагує на сполуку |
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antalarmin[1] |
Онтологія гена |
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Молекулярна функція | • G protein-coupled receptor activity • signal transducer activity • GO:0001948, GO:0016582 protein binding • corticotrophin-releasing factor receptor activity • transmembrane signaling receptor activity • peptide hormone binding • corticotropin-releasing hormone receptor activity • corticotropin-releasing hormone binding • G-protein alpha-subunit binding • пептидний зв'язок • GO:0032403 protein-containing complex binding |
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Клітинна компонента | • integral component of membrane • ендосома • мембрана • intrinsic component of plasma membrane • клітинна мембрана • integral component of plasma membrane • multivesicular body • trans-Golgi network • дендрит (нейробіологія) • везикула • neuronal cell body • apical part of cell |
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Біологічний процес | • corticotropin secretion • жіноча вагітність • activation of adenylate cyclase activity • regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway • cell surface receptor signaling pathway • народження • GO:0046730, GO:0046737, GO:0046738, GO:0046736 імунна відповідь • cellular response to corticotropin-releasing hormone stimulus • regulation of corticosterone secretion • negative regulation of voltage-gated calcium channel activity • GO:0072468 сигнальна трансдукція • G protein-coupled receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • hormone-mediated signaling pathway • response to hypoxia • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • positive regulation of cytosolic calcium ion concentration • neuropeptide signaling pathway • пам'ять • харчова поведінка • visual learning • hypothalamus development • adrenal gland development • epithelial cell differentiation • negative regulation of epinephrine secretion • locomotory exploration behavior • response to immobilization stress • fear response • positive regulation of mast cell degranulation • positive regulation of cAMP-mediated signaling • behavioral response to cocaine • behavioral response to ethanol • regulation of synaptic plasticity • behavioral response to pain • response to electrical stimulus • general adaptation syndrome, behavioral process • довготривала потенціація • negative regulation of neuron death • negative regulation of feeding behavior |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/9/91/PBB_GE_CRHR1_214619_at_fs.png/250px-PBB_GE_CRHR1_214619_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/9/92/PBB_GE_CRHR1_208593_x_at_fs.png/250px-PBB_GE_CRHR1_208593_x_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/2/27/PBB_GE_CRHR1_211897_s_at_fs.png/250px-PBB_GE_CRHR1_211897_s_at_fs.png) |
Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | NM_001145146 NM_001145147 NM_001145148 NM_004382 NM_001303018
| NM_001303020 |
| | NM_007762 NM_001313928 NM_001313929 |
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RefSeq (білок) | NP_001138618 NP_001138619 NP_001138620 NP_001289947 NP_001289949
| NP_004373 |
| | NP_001300857 NP_001300858 NP_031788 |
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Локус (UCSC) | н/д | Хр. 11: 104.02 – 104.07 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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