BMP4 |
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Ідентифікатори |
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Символи | BMP4, BMP2B, BMP2B1, MCOPS6, OFC11, ZYME, bone morphogenetic protein 4 |
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Зовнішні ІД | OMIM: 112262 MGI: 88180 HomoloGene: 7247 GeneCards: BMP4 |
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Онтологія гена |
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Молекулярна функція | • heparin binding • cytokine activity • co-receptor binding • transforming growth factor beta receptor binding • growth factor activity • BMP receptor binding • GO:0001948, GO:0016582 protein binding • chemoattractant activity |
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Клітинна компонента | • extracellular region • міжклітинний простір • endoplasmic reticulum lumen |
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Біологічний процес | • embryonic skeletal system morphogenesis • negative regulation of T cell differentiation in thymus • germ cell development • skeletal system development • mesenchymal cell differentiation involved in renal system development • cardiac septum development • ureteric bud development • positive regulation of protein phosphorylation • renal system process • positive regulation of endothelial cell differentiation • negative regulation of immature T cell proliferation in thymus • bud elongation involved in lung branching • tendon cell differentiation • anatomical structure formation involved in morphogenesis • ureter epithelial cell differentiation • negative regulation of cell cycle • mesenchymal to epithelial transition involved in metanephros morphogenesis • trachea development • post-embryonic development • monocyte differentiation • specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway • blood vessel endothelial cell proliferation involved in sprouting angiogenesis • BMP signaling pathway involved in renal system segmentation • cranial suture morphogenesis • mesonephros development • odontogenesis of dentin-containing tooth • telencephalon regionalization • negative regulation of chondrocyte differentiation • blood vessel development • negative regulation of mitotic nuclear division • Ангіогенез • prostate gland morphogenesis • positive regulation of ERK1 and ERK2 cascade • smooth muscle tissue development • BMP signaling pathway involved in heart induction • negative regulation of epithelial cell proliferation • гістогенез • metanephric collecting duct development • inner ear receptor cell differentiation • mesodermal cell fate determination • metanephros development • type B pancreatic cell development • regulation of pathway-restricted SMAD protein phosphorylation • negative regulation of cell population proliferation • steroid hormone mediated signaling pathway • mammary gland formation • positive regulation of collagen biosynthetic process • renal system development • negative regulation of myoblast differentiation • cell fate commitment • common-partner SMAD protein phosphorylation • glomerular visceral epithelial cell development • SMAD protein signal transduction • осифікація • розвиток нирки • lung development • ureter smooth muscle cell differentiation • embryonic digit morphogenesis • epithelial-mesenchymal cell signaling • negative regulation of thymocyte apoptotic process • mesenchymal cell differentiation involved in kidney development • negative regulation of cell death • regulation of odontogenesis of dentin-containing tooth • BMP signaling pathway involved in ureter morphogenesis • mesenchymal cell proliferation involved in ureteric bud development • smooth muscle cell differentiation • lymphoid progenitor cell differentiation • epithelium development • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • deltoid tuberosity development • negative regulation of prostatic bud formation • heart development • telencephalon development • branching involved in ureteric bud morphogenesis • positive regulation of kidney development • cartilage development • embryonic limb morphogenesis • negative regulation of MAP kinase activity • positive regulation of cartilage development • lens induction in camera-type eye • positive regulation of neuron differentiation • branching involved in prostate gland morphogenesis • regulation of protein import into nucleus • positive regulation of cell differentiation • erythrocyte differentiation • smoothened signaling pathway • camera-type eye development • secondary heart field specification • negative regulation of phosphorylation • regulation of smooth muscle cell differentiation • regulation of cell fate commitment • regulation of branching involved in prostate gland morphogenesis • диференціація клітин • positive regulation of branching involved in lung morphogenesis • chondrocyte differentiation • regulation of cartilage development • organ induction • positive regulation of epithelial cell proliferation • epithelial cell proliferation involved in lung morphogenesis • negative regulation of cell proliferation involved in heart morphogenesis • negative regulation of apoptotic process • positive regulation of ossification • осифікація ендохондральна • regulation of smooth muscle cell proliferation • regulation of morphogenesis of a branching structure • BMP signaling pathway • macrophage differentiation • negative regulation of metanephric comma-shaped body morphogenesis • embryonic skeletal system development • mesenchymal cell proliferation involved in ureter development • osteoblast differentiation • hematopoietic progenitor cell differentiation • positive regulation of BMP signaling pathway • регуляція експресії генів • embryonic cranial skeleton morphogenesis • dorsal/ventral neural tube patterning • lung alveolus development • positive regulation of protein binding • anterior/posterior axis specification • GO:0045996 negative regulation of transcription, DNA-templated • positive regulation of epidermal cell differentiation • branching morphogenesis of an epithelial tube • trachea formation • specification of animal organ position • negative regulation of glomerular mesangial cell proliferation • positive regulation of smooth muscle cell proliferation • intermediate mesodermal cell differentiation • pulmonary artery endothelial tube morphogenesis • pituitary gland development • positive regulation of cell death • lung morphogenesis • positive regulation of endothelial cell proliferation • bud dilation involved in lung branching • positive regulation of cardiac muscle fiber development • negative regulation of striated muscle tissue development • positive regulation of cell migration • negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway • BMP signaling pathway involved in nephric duct formation • positive regulation of pathway-restricted SMAD protein phosphorylation • negative regulation of mesenchymal cell proliferation involved in ureter development • mesoderm formation • cellular response to growth factor stimulus • glomerular capillary formation • bronchus development • positive regulation of endothelial cell migration • multicellular organism development • negative regulation of metanephric S-shaped body morphogenesis • neural tube closure • vasculature development • embryonic morphogenesis • protein localization to nucleus • positive regulation of apoptotic process • embryonic skeletal joint morphogenesis • регуляція диференціювання клітин • negative regulation of branching involved in ureteric bud morphogenesis • mesodermal cell differentiation • neuron fate commitment • forebrain development • cloacal septation • bone development • camera-type eye morphogenesis • positive regulation of SMAD protein signal transduction • negative regulation of glomerulus development • embryonic hindlimb morphogenesis • positive chemotaxis • outflow tract morphogenesis • odontogenesis • GO:1901227 negative regulation of transcription by RNA polymerase II • epithelial to mesenchymal transition involved in endocardial cushion formation • cardiac jelly development • cellular response to BMP stimulus • positive regulation of osteoblast differentiation • epithelial tube branching involved in lung morphogenesis • cardiac muscle cell differentiation • apoptotic process involved in endocardial cushion morphogenesis • muscular septum morphogenesis • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of bone mineralization • cardiac right ventricle morphogenesis • outflow tract septum morphogenesis • membranous septum morphogenesis • aortic valve morphogenesis • pulmonary valve morphogenesis • endocardial cushion development • endoderm development • coronary vasculature development • BMP signaling pathway involved in heart development • pharyngeal arch artery morphogenesis • positive regulation of cell proliferation involved in outflow tract morphogenesis • negative regulation of extrinsic apoptotic signaling pathway • regulation of pri-miRNA transcription by RNA polymerase II • positive regulation of production of miRNAs involved in gene silencing by miRNA • посттрансляційна модифікація • GO:1901313 positive regulation of gene expression • positive regulation of epithelial to mesenchymal transition • positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis • regulation of signaling receptor activity • positive regulation of cell population proliferation • negative regulation of gene expression • negative regulation of pri-miRNA transcription by RNA polymerase II • regulation of apoptotic process • regulation of MAPK cascade • розвиток клітин • ріст |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | NM_001202 NM_130850 NM_130851 |
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RefSeq (білок) | NP_001193 NP_570911 NP_001334841 NP_001334842 NP_001334843
| NP_001334844 NP_001334845 NP_001334846 NP_570912 |
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Локус (UCSC) | н/д | Хр. 14: 46.62 – 46.63 Mb |
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PubMed search | [1] | [2] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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BMP4 (англ. Bone morphogenetic protein 4) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 14-ї хромосоми.[3] Довжина поліпептидного ланцюга білка становить 408 амінокислот, а молекулярна маса — 46 555[4].
Послідовність амінокислот
10 | | 20 | | 30 | | 40 | | 50 |
MIPGNRMLMV | | VLLCQVLLGG | | ASHASLIPET | | GKKKVAEIQG | | HAGGRRSGQS |
HELLRDFEAT | | LLQMFGLRRR | | PQPSKSAVIP | | DYMRDLYRLQ | | SGEEEEEQIH |
STGLEYPERP | | ASRANTVRSF | | HHEEHLENIP | | GTSENSAFRF | | LFNLSSIPEN |
EVISSAELRL | | FREQVDQGPD | | WERGFHRINI | | YEVMKPPAEV | | VPGHLITRLL |
DTRLVHHNVT | | RWETFDVSPA | | VLRWTREKQP | | NYGLAIEVTH | | LHQTRTHQGQ |
HVRISRSLPQ | | GSGNWAQLRP | | LLVTFGHDGR | | GHALTRRRRA | | KRSPKHHSQR |
ARKKNKNCRR | | HSLYVDFSDV | | GWNDWIVAPP | | GYQAFYCHGD | | CPFPLADHLN |
STNHAIVQTL | | VNSVNSSIPK | | ACCVPTELSA | | ISMLYLDEYD | | KVVLKNYQEM |
VVEGCGCR |
Кодований геном білок за функціями належить до цитокінів, факторів росту, білків розвитку, фосфопротеїнів. Задіяний у таких біологічних процесах, як остеогенез, диференціація клітин. Локалізований у позаклітинному матриксі. Також секретований назовні.
Література
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
- Oida S., Iimura T., Maruoka Y., Takeda K., Sasaki S. (1995). Cloning and sequence of bone morphogenetic protein 4 (BMP-4) from a human placental cDNA library. DNA Seq. 5: 273—275. PMID 7579580 DOI:10.3109/10425179509030980
Примітки
- ↑ Human PubMed Reference:.
- ↑ Mouse PubMed Reference:.
- ↑ HUGO Gene Nomenclature Commitee, HGNC:1071 (англ.) . Архів оригіналу за 12 червня 2017. Процитовано 11 вересня 2017.
- ↑ UniProt, P12644 (англ.) . Архів оригіналу за 17 вересня 2017. Процитовано 11 вересня 2017.
Див. також
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Портал «Біологія» Портал «Хімія» |