CCL2 |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 1DOK, 1DOL, 1DOM, 1DON, 1ML0, 2BDN, 2NZ1, 4DN4, 3IFD, 4R8I, 4ZK9 | | |
Ідентифікатори |
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Символи | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF, C-C motif chemokine ligand 2 |
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Зовнішні ІД | OMIM: 158105 HomoloGene: 2245 GeneCards: CCL2 |
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Онтологія гена |
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Молекулярна функція | • signaling receptor binding • protein kinase activity • cytokine activity • GO:0001948, GO:0016582 protein binding • chemokine activity • CCR2 chemokine receptor binding • CCR chemokine receptor binding |
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Клітинна компонента | • extracellular region • міжклітинний простір • внутрішньоклітинний |
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Біологічний процес | • GO:1904089 negative regulation of neuron apoptotic process • viral genome replication • negative regulation of natural killer cell chemotaxis • protein phosphorylation • cell surface receptor signaling pathway • humoral immune response • Ангіогенез • positive regulation of ERK1 and ERK2 cascade • animal organ morphogenesis • cellular homeostasis • cellular response to fibroblast growth factor stimulus • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • inflammatory response • G protein-coupled receptor signaling pathway • monocyte chemotaxis • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • GO:1904579 cellular response to organic cyclic compound • хемотаксис • адгезія клітин • GO:0046730, GO:0046737, GO:0046738, GO:0046736 імунна відповідь • regulation of cell shape • lipopolysaccharide-mediated signaling pathway • receptor signaling pathway via JAK-STAT • response to bacterium • protein kinase B signaling • astrocyte cell migration • negative regulation of glial cell apoptotic process • PERK-mediated unfolded protein response • MAPK cascade • positive regulation of calcium ion import • cytoskeleton organization • GO:0072468 сигнальна трансдукція • regulation of signaling receptor activity • neutrophil chemotaxis • helper T cell extravasation • macrophage chemotaxis • positive regulation of T cell activation • positive regulation of nitric-oxide synthase biosynthetic process • chemokine-mediated signaling pathway • cellular response to lipopolysaccharide • cellular response to interferon-gamma • cellular response to interleukin-1 • cellular response to tumor necrosis factor • positive regulation of apoptotic cell clearance • cytokine-mediated signaling pathway • negative regulation of vascular endothelial cell proliferation • GO:1990376 negative regulation of G1/S transition of mitotic cell cycle • positive regulation of endothelial cell apoptotic process • eosinophil chemotaxis • lymphocyte chemotaxis • sensory perception of pain • positive regulation of synaptic transmission, glutamatergic • positive regulation of NMDA glutamate receptor activity |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | |
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RefSeq (білок) | | |
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Локус (UCSC) | Хр. 17: 34.26 – 34.26 Mb | н/д |
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PubMed search | [1] | [2] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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