IL18 |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 1J0S, 2VXT, 3F62, 4EEE, 4EKX, 4HJJ, 3WO2, 3WO3, 3WO4, 4R6U, 4XFS, 4XFT, 4XFU | | |
Ідентифікатори |
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Символи | IL18, IGIF, IL-18, IL-1g, IL1F4, interleukin 18 |
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Зовнішні ІД | OMIM: 600953 MGI: 107936 HomoloGene: 1200 GeneCards: IL18 |
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Онтологія гена |
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Молекулярна функція | • GO:0001948, GO:0016582 protein binding • cytokine activity • interleukin-18 receptor binding |
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Клітинна компонента | • гіалоплазма • extracellular region • міжклітинний простір |
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Біологічний процес | • positive regulation of inflammatory response • cell-cell signaling • GO:1904579 cellular response to organic cyclic compound • type 2 immune response • MAPK cascade • positive regulation of natural killer cell proliferation • сон • regulation of cell adhesion • positive regulation of NK T cell proliferation • positive regulation of granulocyte macrophage colony-stimulating factor production • positive regulation of tissue remodeling • Ангіогенез • T-helper 1 type immune response • positive regulation of interleukin-17 production • inflammatory response • lipopolysaccharide-mediated signaling pathway • positive regulation of activated T cell proliferation • positive regulation of protein kinase B signaling • positive regulation of phosphatidylinositol 3-kinase signaling • positive regulation of smooth muscle cell proliferation • activation of protein kinase B activity • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of tyrosine phosphorylation of STAT protein • GO:1901313 positive regulation of gene expression • positive regulation of macrophage derived foam cell differentiation • natural killer cell activation • positive regulation of interferon-gamma production • cholesterol homeostasis • positive regulation of T-helper 2 cell differentiation • negative regulation of myoblast differentiation • triglyceride homeostasis • проліферація • regulation of signaling receptor activity • interleukin-6 production • T-helper 1 cell cytokine production • neutrophil activation • natural killer cell mediated cytotoxicity • cytokine-mediated signaling pathway • interleukin-18-mediated signaling pathway • positive regulation of NIK/NF-kappaB signaling • GO:0046730, GO:0046737, GO:0046738, GO:0046736 імунна відповідь • positive regulation of NF-kappaB transcription factor activity • positive regulation of T-helper 1 cell cytokine production • positive regulation of cold-induced thermogenesis • positive regulation of neuroinflammatory response • GO:0072468 сигнальна трансдукція |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | NM_001243211 NM_001562 NM_001386420 |
| | NM_008360 NM_001357221 NM_001357222 |
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RefSeq (білок) | | NP_001230140 NP_001553 NP_001230140.1 |
| | NP_032386 NP_001344150 NP_001344151 |
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Локус (UCSC) | Хр. 11: 112.14 – 112.16 Mb | Хр. 9: 50.47 – 50.49 Mb |
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PubMed search | [1] | [2] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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