PTEN |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 4O1V, 1D5R, 2KYL, 5BZX, 5BUG, 5BZZ | | |
Ідентифікатори |
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Символи | PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1, phosphatase and tensin homolog, Phosphatase and tensin homolog, PTENbeta |
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Зовнішні ІД | OMIM: 601728 MGI: 109583 HomoloGene: 265 GeneCards: PTEN |
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Пов'язані генетичні захворювання |
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head and neck squamous cell carcinoma, macrocephaly-autism syndrome, Cowden syndrome 1, multiple hamartoma syndrome, prostate adenocarcinoma, меланома, prostate carcinoma, Bannayan-Riley-Ruvalcaba syndrome, Proteus-like syndrome[1] |
Онтологія гена |
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Молекулярна функція | • phosphoprotein phosphatase activity • phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity • phosphatidylinositol-3-phosphatase activity • protein serine/threonine phosphatase activity • protein tyrosine phosphatase activity • protein tyrosine/serine/threonine phosphatase activity • enzyme binding • platelet-derived growth factor receptor binding • GO:0001948, GO:0016582 protein binding • protein kinase binding • phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity • anaphase-promoting complex binding • identical protein binding • hydrolase activity • lipid binding • ubiquitin-specific protease binding • ionotropic glutamate receptor binding • protein tyrosine kinase binding • inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity • PDZ domain binding |
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Клітинна компонента | • цитоплазма • postsynaptic membrane • extracellular region • мітохондрія • neuron projection • cytoplasmic side of plasma membrane • клітинне ядро • cell projection • dendritic spine • myelin sheath adaxonal region • Schmidt-Lanterman incisure • apical plasma membrane • клітинна мембрана • PML body • нуклеоплазма • гіалоплазма • postsynaptic cytosol |
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Біологічний процес | • multicellular organismal response to stress • regulation of neuron projection development • response to zinc ion • positive regulation of TRAIL-activated apoptotic signaling pathway • response to organic substance • GO:1990376 negative regulation of G1/S transition of mitotic cell cycle • regulation of B cell apoptotic process • Ангіогенез • positive regulation of ERK1 and ERK2 cascade • negative regulation of epithelial cell proliferation • Довготривале пригнічення • positive regulation of excitatory postsynaptic potential • проліферація • response to ethanol • neuron projection development • cellular response to hypoxia • negative regulation of cell size • negative regulation of cell population proliferation • prepulse inhibition • regulation of myeloid cell apoptotic process • male mating behavior • locomotory behavior • dentate gyrus development • positive regulation of apoptotic signaling pathway • inositol phosphate metabolic process • response to arsenic-containing substance • пам'ять • forebrain morphogenesis • dendritic spine morphogenesis • heart development • central nervous system development • negative regulation of axonogenesis • regulation of cellular localization • synapse maturation • learning or memory • соціальна поведінка • synapse assembly • cellular response to decreased oxygen levels • prostate gland growth • platelet-derived growth factor receptor signaling pathway • negative regulation of dendritic spine morphogenesis • brain morphogenesis • GO:0033128 negative regulation of protein phosphorylation • regulation of cyclin-dependent protein serine/threonine kinase activity • regulation of cellular component size • response to nutrient • negative regulation of synaptic vesicle clustering • postsynaptic density assembly • GO:0016576 protein dephosphorylation • protein stabilization • positive regulation of DNA-binding transcription factor activity • negative regulation of apoptotic process • response to glucose • нейробіологія розвитку • adult behavior • phosphatidylinositol dephosphorylation • positive regulation of ubiquitin-dependent protein catabolic process • response to inorganic substance • canonical Wnt signaling pathway • phosphatidylinositol biosynthetic process • negative regulation of organ growth • negative regulation of ribosome biogenesis • GO:0098501, GO:0098502, GO:0006286 дефосфорилювання • locomotor rhythm • central nervous system myelin maintenance • regulation of axon regeneration • response to estradiol • response to ATP • negative regulation of phagocytosis • GO:1904578 response to organic cyclic compound • protein kinase B signaling • cardiac muscle tissue development • lipid metabolism • GO:0010260 старіння людини • neuron-neuron synaptic transmission • negative regulation of excitatory postsynaptic potential • presynaptic membrane assembly • regulation of cell cycle • maternal behavior • rhythmic synaptic transmission • positive regulation of cell population proliferation • positive regulation of apoptotic process • negative regulation of ERK1 and ERK2 cascade • cell migration • negative regulation of myelination • inositol phosphate dephosphorylation • regulation of synaptic transmission, GABAergic • endothelial cell migration • central nervous system neuron axonogenesis • довготривала потенціація • peptidyl-tyrosine dephosphorylation • negative regulation of axon regeneration • negative regulation of cardiac muscle cell proliferation • GO:0090623, GO:1903835, GO:0007092, GO:0051488, GO:0051487 positive regulation of ubiquitin protein ligase activity • protein deubiquitination • negative regulation of epithelial to mesenchymal transition • negative regulation of keratinocyte migration • cellular response to electrical stimulus • negative regulation of wound healing, spreading of epidermal cells • negative regulation of phosphatidylinositol 3-kinase signaling • GO:1901313 positive regulation of gene expression • positive regulation of cardiac muscle cell apoptotic process • response to activity • cellular response to insulin stimulus • cellular response to leptin stimulus • positive regulation of neuron differentiation • cellular response to ethanol • negative regulation of potassium ion transmembrane transporter activity • cellular response to nerve growth factor stimulus • cellular response to insulin-like growth factor stimulus • negative regulation of signaling receptor activity • negative regulation of protein kinase B signaling • GO:0097285 апоптоз • negative regulation of cell migration • regulation of protein stability • negative regulation of focal adhesion assembly • negative regulation of vascular associated smooth muscle cell proliferation • transcription initiation from RNA polymerase II promoter • negative regulation of cyclin-dependent protein serine/threonine kinase activity • negative regulation of neuron projection development |
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Джерела:Amigo / QuickGO | |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | ENSG00000171862 ENSG00000284792 |
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UniProt | | |
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RefSeq (мРНК) | | NM_000314 NM_001304717 NM_001304718 |
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RefSeq (білок) | | NP_000305 NP_001291646 NP_001291647 NP_000305.3 |
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Локус (UCSC) | Хр. 10: 87.86 – 87.97 Mb | Хр. 19: 32.73 – 32.8 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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