BCL11B

Mã định danh

Danh pháp

BCL11B, ATL1, ATL1-alpha, ATL1-beta, ATL1-delta, ATL1-gamma, CTIP-2, CTIP2, RIT1, ZNF856B, hRIT1-alpha, B-cell CLL/lymphoma 11B, IMD49, B cell CLL/lymphoma 11B, IDDFSTA, BAF complex component, BAF chromatin remodeling complex subunit SMARCM2

ID ngoài

OMIM: 606558 HomoloGene: 10974 GeneCards: BCL11B

Vị trí gen (Người)

NST	Nhiễm sắc thể 14 (người)^[1]

Băng	14q32.2	Bắt đầu	99,169,287 bp^[1]
Băng	14q32.2	Kết thúc	99,272,197 bp^[1]

Mẫu hình biểu hiện RNA

Thêm nguồn tham khảo về sự biểu hiện

Bản thể gen
Chức năng phân tử	• sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • metal ion binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
Thành phần tế bào	• nội bào • neuron projection • nhân tế bào
Quá trình sinh học	• commitment of neuronal cell to specific neuron type in forebrain • regulation of neuron differentiation • neurogenesis • olfactory bulb axon guidance • GO:0009373 regulation of transcription, DNA-templated • T cell differentiation in thymus • axonogenesis • epithelial cell morphogenesis • thymus development • T cell receptor V(D)J recombination • negative regulation of apoptotic process • transcription by RNA polymerase II • post-embryonic development • positive T cell selection • transcription, DNA-templated • striatal medium spiny neuron differentiation • odontogenesis of dentin-containing tooth • regulation of lipid metabolic process • keratinocyte development • post-embryonic camera-type eye development • central nervous system neuron differentiation • regulation of gene expression • alpha-beta T cell differentiation • regulation of keratinocyte proliferation • GO:0072468 signal transduction • negative regulation of cell population proliferation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • skin development • hematopoietic stem cell migration • lymphoid lineage cell migration into thymus
Nguồn: Amigo / QuickGO

Gen cùng nguồn

Loài

Người

Chuột

Entrez


64919


n/a

Ensembl


ENSG00000127152


n/a

UniProt


Q9C0K0


n/a

RefSeq (mRNA)


NM_001282237 NM_001282238 NM_022898 NM_138576


n/a

RefSeq (protein)


NP_001269166 NP_001269167 NP_075049 NP_612808


n/a

Vị trí gen (UCSC)

Chr 14: 99.17 – 99.27 Mb

n/a

PubMed

^[2]

n/a

Wikidata

Xem/Sửa Người

B-cell lymphoma/leukemia 11B là một protein ở người được mã hóa bởi gen BCL11B.^[3]^[4]^[5]

Tương tác

BCL11B đã cho thấy có tương tác với COUP-TFI.^[6]

Tham khảo

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127152 - Ensembl, May 2017
^ “Human PubMed Reference:”.
^ Satterwhite E, Sonoki T, Willis TG, Harder L, Nowak R, Arriola EL, Liu H, Price HP, Gesk S, Steinemann D, Schlegelberger B, Oscier DG, Siebert R, Tucker PW, Dyer MJ (tháng 11 năm 2001). “The BCL11 gene family: involvement of BCL11A in lymphoid malignancies”. Blood. 98 (12): 3413–20. doi:10.1182/blood.V98.12.3413. PMID 11719382.
^ Topark-Ngarm A, Golonzhka O, Peterson VJ, Barrett B, Martinez B, Crofoot K, Filtz TM, Leid M (tháng 10 năm 2006). “CTIP2 associates with the NuRD complex on the promoter of p57KIP2, a newly identified CTIP2 target gene”. J. Biol. Chem. 281 (43): 32272–83. doi:10.1074/jbc.M602776200. PMC 2547407. PMID 16950772.
^ “Entrez Gene: BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)”.
^ Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M (tháng 4 năm 2000). “Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors”. J. Biol. Chem. 275 (14): 10315–22. doi:10.1074/jbc.275.14.10315. PMC 2819356. PMID 10744719.

Đọc thêm

Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M (2000). “Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors”. J. Biol. Chem. 275 (14): 10315–22. doi:10.1074/jbc.275.14.10315. PMC 2819356. PMID 10744719.
Avram D, Fields A, Senawong T, Topark-Ngarm A, Leid M (2002). “COUP-TF (chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding protein”. Biochem. J. 368 (Pt 2): 555–63. doi:10.1042/BJ20020496. PMC 1223006. PMID 12196208.
Wakabayashi Y, Inoue J, Takahashi Y, Matsuki A, Kosugi-Okano H, Shinbo T, Mishima Y, Niwa O, Kominami R (2003). “Homozygous deletions and point mutations of the Rit1/Bcl11b gene in gamma-ray induced mouse thymic lymphomas”. Biochem. Biophys. Res. Commun. 301 (2): 598–603. doi:10.1016/S0006-291X(02)03069-3. PMID 12565905.
Rohr O, Lecestre D, Chasserot-Golaz S, Marban C, Avram D, Aunis D, Leid M, Schaeffer E (2003). “Recruitment of Tat to heterochromatin protein HP1 via interaction with CTIP2 inhibits human immunodeficiency virus type 1 replication in microglial cells”. J. Virol. 77 (9): 5415–27. doi:10.1128/JVI.77.9.5415-5427.2003. PMC 153947. PMID 12692243.
Senawong T, Peterson VJ, Avram D, Shepherd DM, Frye RA, Minucci S, Leid M (2003). “Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression”. J. Biol. Chem. 278 (44): 43041–50. doi:10.1074/jbc.M307477200. PMC 2819354. PMID 12930829.
Bezrookove V, van Zelderen-Bhola SL, Brink A, Szuhai K, Raap AK, Barge R, Beverstock GC, Rosenberg C (2004). “A novel t(6;14)(q25-q27;q32) in acute myelocytic leukemia involves the BCL11B gene”. Cancer Genet. Cytogenet. 149 (1): 72–6. doi:10.1016/S0165-4608(03)00302-9. PMID 15104287.
MacLeod RA, Nagel S, Drexler HG (2004). “BCL11B rearrangements probably target T-cell neoplasia rather than acute myelocytic leukemia”. Cancer Genet. Cytogenet. 153 (1): 88–9. doi:10.1016/j.cancergencyto.2004.02.020. PMID 15325104.
Przybylski GK, Dik WA, Wanzeck J, Grabarczyk P, Majunke S, Martin-Subero JI, Siebert R, Dölken G, Ludwig WD, Verhaaf B, van Dongen JJ, Schmidt CA, Langerak AW (2005). “Disruption of the BCL11B gene through inv(14)(q11.2q32.31) results in the expression of BCL11B-TRDC fusion transcripts and is associated with the absence of wild-type BCL11B transcripts in T-ALL”. Leukemia. 19 (2): 201–8. doi:10.1038/sj.leu.2403619. PMID 15668700.
Cismasiu VB, Adamo K, Gecewicz J, Duque J, Lin Q, Avram D (2005). “BCL11B functionally associates with the NuRD complex in T lymphocytes to repress targeted promoter”. Oncogene. 24 (45): 6753–64. doi:10.1038/sj.onc.1208904. PMID 16091750.
Marban C, Suzanne S, Dequiedt F, de Walque S, Redel L, Van Lint C, Aunis D, Rohr O (2007). “Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing”. EMBO J. 26 (2): 412–23. doi:10.1038/sj.emboj.7601516. PMC 1783449. PMID 17245431.
Nagel S, Scherr M, Kel A, Hornischer K, Crawford GE, Kaufmann M, Meyer C, Drexler HG, MacLeod RA (2007). “Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1”. Cancer Res. 67 (4): 1461–71. doi:10.1158/0008-5472.CAN-06-2615. PMID 17308084.
Kamimura K, Mishima Y, Obata M, Endo T, Aoyagi Y, Kominami R (2007). “Lack of Bcl11b tumor suppressor results in vulnerability to DNA replication stress and damages”. Oncogene. 26 (40): 5840–50. doi:10.1038/sj.onc.1210388. PMID 17369851.

Liên kết ngoài

MeSH BCL11B+protein,+human
Vị trí bộ gen ATL1 ở người và thông tin chi tiết về gen ATL1 có sẵn trên UCSC Genome Browser.
Vị trí bộ gen BCL11B ở người và thông tin chi tiết về gen BCL11B có sẵn trên UCSC Genome Browser.
Vị trí bộ gen RIT1 ở người và thông tin chi tiết về gen RIT1 có sẵn trên UCSC Genome Browser.