7,8,3'-三羟基黄酮
- 未分配
- 7,8-Dihydroxy-2-(3-hydroxyphenyl)chromen-4-one
- 676310
- 589045
- F67B8S3MH9
- ChEMBL225513
- DTXSID00350274
- 交互式图像
- C1=CC(=CC(=C1)O)C2=CC(=O)C3=C(O2)C(=C(C=C3)O)O
- InChI=1S/C15H10O5/c16-9-3-1-2-8(6-9)13-7-12(18)10-4-5-11(17)14(19)15(10)20-13/h1-7,16-17,19H
- Key:ZJZSQGDOCUHCCW-UHFFFAOYSA-N
7,8,3'-三羟基黄酮（英語：7,8,3′-Trihydroxyflavone，缩写为7,8,3'-THF）是一种黄酮类化合物，7,8-二羟基黄酮的衍生物，可作为脑源性神经营养因子受体TrkB的小分子激动剂[1][2]。
参考文献
- ^ Liu X, Chan CB, Jang SW, Pradoldej S, Huang J, He K, et al. A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect. Journal of Medicinal Chemistry. December 2010, 53 (23): 8274–86. PMC 3150605
. PMID 21073191. doi:10.1021/jm101206p. - ^ Yu Q, Chang Q, Liu X, Gong S, Ye K, Lin X. 7,8,3'-Trihydroxyflavone, a potent small molecule TrkB receptor agonist, protects spiral ganglion neurons from degeneration both in vitro and in vivo. Biochemical and Biophysical Research Communications. June 2012, 422 (3): 387–92. PMC 3388121 . PMID 22575512. doi:10.1016/j.bbrc.2012.04.154.
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