ABT-724
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识别信息 | |
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CAS号 | 70006-24-5 ![]() |
PubChem CID |
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ChemSpider |
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UNII |
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ChEMBL |
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CompTox Dashboard(英语:CompTox Chemicals Dashboard) (EPA) |
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化学信息 | |
化学式 | C17H19N5 |
摩尔质量 | 293.37 g·mol−1 |
3D模型(JSmol(英语:JSmol)) |
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ABT-724是一种含氮有机化合物,分子式C17H19N5,是一种多巴胺受体D4的选择性激动剂[1],作为治疗勃起功能障碍的潜在药物而开发[2]。
参考文献
- ^ Brioni JD, Moreland RB, Cowart M, Hsieh GC, Stewart AO, Hedlund P, et al. Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats. Proceedings of the National Academy of Sciences of the United States of America. April 2004, 101 (17): 6758–6763. Bibcode:2004PNAS..101.6758B. PMC 404118
. PMID 15087502. doi:10.1073/pnas.0308292101
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- ^ Cowart M, Latshaw SP, Bhatia P, Daanen JF, Rohde J, Nelson SL, et al. Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction. Journal of Medicinal Chemistry. July 2004, 47 (15): 3853–3864. PMID 15239663. doi:10.1021/jm030505a.