HP-505
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识别信息 | |
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CAS号 | 59142-94-8 ![]() |
PubChem CID |
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ChEMBL |
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CompTox Dashboard(英语:CompTox Chemicals Dashboard) (EPA) |
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化学信息 | |
化学式 | C18H19NO |
摩尔质量 | 265.36 g·mol−1 |
3D模型(JSmol(英语:JSmol)) |
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HP-505是一种有机化合物,化学式为C18H19NO。它是由赫美罗制药公司(英语:Hoechst-Marion-Roussel)研发的三重再摄取抑制剂。[1]HP-505在小鼠试验中发现是丁苯那嗪(英语:tetrabenazine)诱导的上睑下垂(英语:ptosis)的有效抑制剂,这表明它可能具有抗抑郁活性。[2]
药理学
5-HT | NE | DA | NE:5-HT | DA:5-HT |
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0.19 ± 0.04 | 0.34 ± 0.1 | 0.66 ± 0.15 | 1.8 | 3.5 |
化学性质
HP-505在碳酸氢钠存在下,可以和2-氯-4-硝基吡啶-1-氧化物反应,得到N-(1-氧化-4-硝基吡啶-2-基)-HP-505。[3]
参考文献
- ^ 1.0 1.1 Meyerson, Laurence R; Ong, Helen H; Martin, Lawrence L; Ellis, Daniel B. Effect of antidepressant agents on β-adrenergic receptor and neurotransmitter regulatory systems. Pharmacology Biochemistry and Behavior. June 1980, 12 (6): 943–948. PMID 6105676. S2CID 45400599. doi:10.1016/0091-3057(80)90457-8.
- ^ Klioze, SS; Bauer, VJ; Geyer HM, 3rd. Synthesis of spiro[isobenzofuran-1(3H),4'-piperidines] as potential central nervous system agents. 2. Compounds containing a heteroatom attached to nitrogen.. Journal of Medicinal Chemistry. April 1977, 20 (4): 610–2. PMID 850252. doi:10.1021/jm00214a039.
- ^ Allerton, Charlotte Moira Norfor; Owen, Dafydd Rhys; Ryckmans, Thomas; Stammen, Blanda Luzia Christa. Spiropiperidine derivatives, processes for preparing them, pharmaceutical compositions containing them, and their use as delta opioid receptor agonists. 2007 WO 2007057775 A1.