SIN3B

SIN3转录调节同源物B（酵母）
SIN3 transcription regulator homolog B (yeast)
PDB rendering based on 1e91.
有效结构
PDB 直系同源检索：PDBe, RCSB
PDB查询代码列表

1e91, 1pd7, 2cr7, 2czy, 2f05

标识
代号 SIN3B; KIAA0700
扩展标识 遗传学：607777 鼠基因：107158 同源基因：81810 GeneCards: SIN3B Gene
基因本体论描述
分子功能 · chromatin binding

· transcription corepressor activity

· protein binding
细胞成分 · X chromosome

· Y chromosome
· XY body
· nucleus
· nucleoplasm
· cytoplasm

· autosome
生物过程 · transcription, DNA-dependent

· skeletal muscle tissue development
· cellular lipid metabolic process
· small molecule metabolic process
· negative regulation of transcription, DNA-dependent

· cardiac muscle tissue development
Sources: Amigo / QuickGO
RNA表达模式
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 23309 20467
Ensembl ENSG00000127511 ENSMUSG00000031622
UniProt O75182 Q62141
mRNA序列 NM_015260 NM_001113248
蛋白序列 NP_056075 NP_001106719
基因位置 Chr 19:
16.94 – 16.99 Mb		 Chr 8:
72.72 – 72.76 Mb
PubMed查询 [1] [2]
  • 查
  • 论
  • 编

成对两亲性螺旋蛋白SIN3B（英語：Paired amphipathic helix protein Sin3b）是一个由人类基因SIN3B编码的蛋白质[1][2]。

互作

SIN3B与HDAC1[3][4]、Zinc finger and BTB domain-containing protein 16[5]、SUDS3[6]以及IKZF1[4][7]等蛋白有相互作用。

另见

  • Transcription coregulator

参考文献

  1. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. December 1998, 5 (3): 169–76. PMID 9734811. doi:10.1093/dnares/5.3.169. 
  2. ^ Entrez Gene: SIN3B SIN3 homolog B, transcription regulator (yeast). 
  3. ^ Zhang, Y; Ng H H, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D. Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev. (UNITED STATES). August 1999, 13 (15): 1924–35. ISSN 0890-9369. PMC 316920 可免费查阅. PMID 10444591. doi:10.1101/gad.13.15.1924.  引文使用过时参数coauthors (帮助)
  4. ^ 4.0 4.1 Koipally, J; Renold A, Kim J, Georgopoulos K. Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. EMBO J. (ENGLAND). June 1999, 18 (11): 3090–100. ISSN 0261-4189. PMC 1171390 可免费查阅. PMID 10357820. doi:10.1093/emboj/18.11.3090.  引文使用过时参数coauthors (帮助)
  5. ^ David, G; Alland L, Hong S H, Wong C W, DePinho R A, Dejean A. Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein. Oncogene (ENGLAND). May 1998, 16 (19): 2549–56. ISSN 0950-9232. PMID 9627120. doi:10.1038/sj.onc.1202043.  引文使用过时参数coauthors (帮助)
  6. ^ Alland, Leila; David Gregory, Shen-Li Hong, Potes Jason, Muhle Rebecca, Lee Hye-Chun, Hou Harry, Chen Ken, DePinho Ronald A. Identification of Mammalian Sds3 as an Integral Component of the Sin3/Histone Deacetylase Corepressor Complex. Mol. Cell. Biol. (United States). April 2002, 22 (8): 2743–50. ISSN 0270-7306. PMC 133736 可免费查阅. PMID 11909966. doi:10.1128/MCB.22.8.2743-2750.2002.  引文使用过时参数coauthors (帮助)
  7. ^ Koipally, Joseph; Georgopoulos Katia. A molecular dissection of the repression circuitry of Ikaros. J. Biol. Chem. (United States). August 2002, 277 (31): 27697–705. ISSN 0021-9258. PMID 12015313. doi:10.1074/jbc.M201694200.  引文使用过时参数coauthors (帮助)

延伸阅读

  • Ayer DE, Lawrence QA, Eisenman RN. Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3. Cell. 1995, 80 (5): 767–76. PMID 7889570. doi:10.1016/0092-8674(95)90355-0. 
  • David G, Alland L, Hong SH; et al. Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein. Oncogene. 1998, 16 (19): 2549–56. PMID 9627120. doi:10.1038/sj.onc.1202043.  引文格式1维护：显式使用等标签 (link)
  • Koipally J, Renold A, Kim J, Georgopoulos K. Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. EMBO J. 1999, 18 (11): 3090–100. PMC 1171390 可免费查阅. PMID 10357820. doi:10.1093/emboj/18.11.3090. 
  • Naruse Y, Aoki T, Kojima T, Mori N. Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genes. Proc. Natl. Acad. Sci. U.S.A. 2000, 96 (24): 13691–6. PMC 24126 可免费查阅. PMID 10570134. doi:10.1073/pnas.96.24.13691. 
  • Spronk CA, Tessari M, Kaan AM; et al. The Mad1-Sin3B interaction involves a novel helical fold. Nat. Struct. Biol. 2001, 7 (12): 1100–4. PMID 11101889. doi:10.1038/81944.  引文格式1维护：显式使用等标签 (link)
  • Spronk CA, Jansen JF, Tessari M; et al. Sequence-specific assignment of the PAH2 domain of Sin3B free and bound to Mad1. J. Biomol. NMR. 2001, 19 (4): 377–8. PMID 11370785. doi:10.1023/A:1011262214741.  引文格式1维护：显式使用等标签 (link)
  • Alland L, David G, Shen-Li H; et al. Identification of Mammalian Sds3 as an Integral Component of the Sin3/Histone Deacetylase Corepressor Complex. Mol. Cell. Biol. 2002, 22 (8): 2743–50. PMC 133736 可免费查阅. PMID 11909966. doi:10.1128/MCB.22.8.2743-2750.2002.  引文格式1维护：显式使用等标签 (link)
  • Rayman JB, Takahashi Y, Indjeian VB; et al. E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex. Genes Dev. 2002, 16 (8): 933–47. PMC 152357 可免费查阅. PMID 11959842. doi:10.1101/gad.969202.  引文格式1维护：显式使用等标签 (link)
  • Koipally J, Georgopoulos K. A molecular dissection of the repression circuitry of Ikaros. J. Biol. Chem. 2002, 277 (31): 27697–705. PMID 12015313. doi:10.1074/jbc.M201694200. 
  • Yang L, Mei Q, Zielinska-Kwiatkowska A; et al. An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B. Biochem. J. 2003, 369 (Pt 3): 651–7. PMC 1223118 可免费查阅. PMID 12398767. doi:10.1042/BJ20020854.  引文格式1维护：显式使用等标签 (link)
  • Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 可免费查阅. PMID 12477932. doi:10.1073/pnas.242603899.  引文格式1维护：显式使用等标签 (link)
  • Petrie K, Guidez F, Howell L; et al. The histone deacetylase 9 gene encodes multiple protein isoforms. J. Biol. Chem. 2003, 278 (18): 16059–72. PMID 12590135. doi:10.1074/jbc.M212935200.  引文格式1维护：显式使用等标签 (link)
  • Wysocka J, Myers MP, Laherty CD; et al. Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. Genes Dev. 2003, 17 (7): 896–911. PMC 196026 可免费查阅. PMID 12670868. doi:10.1101/gad.252103.  引文格式1维护：显式使用等标签 (link)
  • Ota T, Suzuki Y, Nishikawa T; et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.  引文格式1维护：显式使用等标签 (link)
  • Dugast-Darzacq C, Pirity M, Blanck JK; et al. Mxi1-SRalpha: a novel Mxi1 isoform with enhanced transcriptional repression potential. Oncogene. 2004, 23 (55): 8887–99. PMID 15467743. doi:10.1038/sj.onc.1208107.  引文格式1维护：显式使用等标签 (link)
  • Gerhard DS, Wagner L, Feingold EA; et al. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 可免费查阅. PMID 15489334. doi:10.1101/gr.2596504.  引文格式1维护：显式使用等标签 (link)
  • Rampalli S, Pavithra L, Bhatt A; et al. Tumor Suppressor SMAR1 Mediates Cyclin D1 Repression by Recruitment of the SIN3/Histone Deacetylase 1 Complex. Mol. Cell. Biol. 2005, 25 (19): 8415–29. PMC 1265755 可免费查阅. PMID 16166625. doi:10.1128/MCB.25.19.8415-8429.2005.  引文格式1维护：显式使用等标签 (link)
  • Xu Y, Sengupta PK, Seto E, Smith BD. RFX family proteins differentially interact with HDACs to repress collagen alpha 2(I) gene (COL1A2) expression. J. Biol. Chem. 2006, 281 (14): 9260–70. PMC 1434794 可免费查阅. PMID 16464847. doi:10.1074/jbc.M511724200. 

外部链接

SIN3B引用了美国国家医学图书馆提供的資料，这些資料属于公共领域。

  • 查
  • 论
  • 编
  • Template:PDB Gallery/23309
  • 查
  • 论
  • 编
转录辅调节因子（英语：Transcription coregulator）
共激活因子（英语：Coactivators）
  • ARA (54, 55, 70)
  • BCAS3
  • CARM1
  • p300-CBP (EP300, CREBBP)
  • CRTC (1, 2, 3)
  • DRIP/TRAP
  • MN1
  • PCAF
  • PNRC (1, 2)
  • PPARGC (1A, 1B)
  • TGFB1I1
    NCOA1 (SRC-1)
  • NCOA2 (GRIP1/SRC-2/TIF2)
  • NCOA3 (AIB/SRC-3/TRAM-1)
  • NCOA4 (ARA70)
  • NCOA5 (CIA)
  • NCOA6 (RAP250)
  • NCOA7 (ERAP140)
共阻遏因子（英语：Corepressors）
  • CTBP (1, 2)
  • Hairless homolog
  • LCOR
  • NRIP1 (RIP140)
  • PELP-1
  • RCOR1
  • Rb
  • SIN3A
  • SIN3B
  • Tripartite motif family TRIM (24, 28, 33)
    NCOR1
  • NCOR2 (SMRT)
ATP-依賴性重塑因子
  • Chromatin Structure Remodeling (RSC) Complex
  • SWI/SNF
參見:transcription factor/coregulator deficiencies
  • 查
  • 论
  • 编
遗传学索引
描述
  • 生化
  • 基因表达
  • DNA
    • 复制
    • 周期蛋白
    • 基因重组
    • 修复
  • 转录
    • 转录因子与细胞内受体
    • 辅调节因子
    • RNA
    • 重复序列
    • 转录后修饰
  • 翻译
    • 核糖体亚基
    • 翻译后修饰
    • 分拣蛋白（英语：Template:Sorting nexin）
  • DNA结合蛋白（英语：Template:DNA-binding proteins）/RNA结合蛋白（英语：Template:RNA-binding proteins）
    • 核糖核蛋白)
  • 蛋白质
    • 结构域
    • 结构
      • 1°
      • 2°
      • 2+°
      • 3°
      • 4°
疾病
  • Replication and repair（英语：Template:DNA replication and repair-deficiency disorder）
  • Transcription factor（英语：Template:Transcription factor and coregulator deficiencies）
  • 转录相关疾病（英语：Template:Disorders of transcription and post transcriptional modification）
  • 轉譯相關疾病