CCL3 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/b/ba/Protein_CCL3_PDB_1b50.png/250px-Protein_CCL3_PDB_1b50.png) |
Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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1B50, 1B53, 2X69, 2X6G, 3FPU, 3H44, 3KBX, 4RA8, 4ZKB, 5D65, 5COR |
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Identifiers |
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Aliases | CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3, C-C motif chemokine ligand 3 |
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External IDs | OMIM: 182283; MGI: 98260; HomoloGene: 88430; GeneCards: CCL3; OMA:CCL3 - orthologs |
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Gene location (Human) |
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![Chromosome 17 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/0/00/Ideogram_human_chromosome_17.svg/300px-Ideogram_human_chromosome_17.svg.png) | Chr. | Chromosome 17 (human)[1] |
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| Band | 17q12 | Start | 36,088,256 bp[1] |
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End | 36,090,169 bp[1] |
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Gene location (Mouse) |
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![Chromosome 11 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Ideogram_house_mouse_chromosome_11.svg/260px-Ideogram_house_mouse_chromosome_11.svg.png) | Chr. | Chromosome 11 (mouse)[2] |
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| Band | 11 C|11 51.04 cM | Start | 83,538,670 bp[2] |
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End | 83,540,181 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - bone marrow
- granulocyte
- spleen
- monocyte
- bone marrow cells
- gallbladder
- placenta
- testicle
- lymph node
- appendix
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| Top expressed in | - granulocyte
- stroma of bone marrow
- calvaria
- spermatid
- blood
- dermis
- secondary oocyte
- thymus
- islet of Langerhans
- right kidney
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/9/9f/PBB_GE_CCL3_205114_s_at_fs.png/250px-PBB_GE_CCL3_205114_s_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - protein kinase activity
- cytokine activity
- CCR5 chemokine receptor binding
- chemokine activity
- CCR1 chemokine receptor binding
- kinase activity
- phospholipase activator activity
- calcium-dependent protein kinase C activity
- protein binding
- identical protein binding
- chemoattractant activity
- CCR chemokine receptor binding
| Cellular component | - cytoplasm
- cytosol
- intracellular anatomical structure
- extracellular region
- extracellular space
| Biological process | - G protein-coupled receptor signaling pathway
- signaling
- negative regulation of bone mineralization
- positive regulation of protein kinase B signaling
- release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
- response to cholesterol
- positive regulation of calcium-mediated signaling
- regulation of sensory perception of pain
- protein kinase B signaling
- monocyte chemotaxis
- negative regulation of osteoclast differentiation
- astrocyte cell migration
- positive regulation of cell migration
- positive regulation of natural killer cell chemotaxis
- chemokine-mediated signaling pathway
- T cell chemotaxis
- cell-cell signaling
- cellular response to tumor necrosis factor
- eosinophil chemotaxis
- cellular response to organic cyclic compound
- cellular calcium ion homeostasis
- negative regulation of gene expression
- neutrophil chemotaxis
- cell activation
- MAPK cascade
- chemotaxis
- positive regulation of GTPase activity
- positive regulation of neuron apoptotic process
- positive regulation of calcium ion import
- macrophage chemotaxis
- positive regulation of gene expression
- cytoskeleton organization
- osteoblast differentiation
- cellular response to interleukin-1
- immune response
- positive regulation of ERK1 and ERK2 cascade
- regulation of cell shape
- positive regulation of tumor necrosis factor production
- cellular response to interferon-gamma
- lymphocyte chemotaxis
- inflammatory response
- granulocyte chemotaxis
- response to toxic substance
- eosinophil degranulation
- lipopolysaccharide-mediated signaling pathway
- calcium ion transport
- calcium-mediated signaling
- exocytosis
- positive regulation of calcium ion transport
- positive chemotaxis
- positive regulation of inflammatory response
- regulation of signaling receptor activity
- cytokine-mediated signaling pathway
- regulation of behavior
- positive regulation of microglial cell activation
- positive regulation of microglial cell migration
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | |
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ENSG00000278567 ENSG00000277632 ENSG00000274221 |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 17: 36.09 – 36.09 Mb | Chr 11: 83.54 – 83.54 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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