POLR2H

Protein-coding gene in the species Homo sapiens

POLR2H

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2F3I, 5FLM, 5IY9, 5IYA, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6

Identifiers

Aliases

POLR2H, RPABC3, RPB17, RPB8, polymerase (RNA) II subunit H, RNA polymerase II subunit H, RNA polymerase II, I and III subunit H

External IDs

OMIM: 606023; MGI: 2384309; HomoloGene: 4540; GeneCards: POLR2H; OMA:POLR2H - orthologs

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3q27.1	Start	184,361,718 bp^[1]
Band	3q27.1	End	184,368,596 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 16 (mouse)^[2]

Band	16\|16 B1	Start	20,536,415 bp^[2]
Band	16\|16 B1	End	20,541,017 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

mucosa of transverse colon

pancreatic ductal cell

right lobe of thyroid gland

right uterine tube

left lobe of thyroid gland

right adrenal gland

right adrenal cortex

left adrenal cortex

rectum

canal of the cervix

Top expressed in

epiblast

embryo

morula

embryo

ventricular zone

neural tube

yolk sac

tail of embryo

ganglionic eminence

ileum

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	DNA-directed 5'-3' RNA polymerase activity DNA binding RNA polymerase I activity RNA polymerase II activity RNA polymerase III activity single-stranded DNA binding
Cellular component	nucleolus RNA polymerase II, core complex nucleoplasm cytosol nucleus RNA polymerase III complex RNA polymerase I complex protein-DNA complex
Biological process	7-methylguanosine mRNA capping transcription elongation from RNA polymerase II promoter transcription initiation from RNA polymerase I promoter mRNA splicing, via spliceosome epigenetic maintenance of chromatin in transcription-competent conformation transcription-coupled nucleotide-excision repair termination of RNA polymerase I transcription transcription initiation from RNA polymerase II promoter transcription by RNA polymerase II snRNA transcription by RNA polymerase II fibroblast growth factor receptor signaling pathway transcription by RNA polymerase III RNA metabolic process regulation of gene silencing by miRNA transcription, DNA-templated transcription elongation from RNA polymerase I promoter positive regulation of type I interferon production somatic stem cell population maintenance positive regulation of viral transcription
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5437


245841

Ensembl


ENSG00000163882


ENSMUSG00000021018

UniProt


P52434


Q923G2

RefSeq (mRNA)

NM_001278698 NM_001278699 NM_001278700 NM_001278714 NM_001278715
NM_006232 NM_001346879


NM_145632 NM_001356423

RefSeq (protein)

NP_001265627 NP_001265628 NP_001265629 NP_001265643 NP_001265644
NP_001333808 NP_006223


NP_663607 NP_001343352

Location (UCSC)

Chr 3: 184.36 – 184.37 Mb

Chr 16: 20.54 – 20.54 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

DNA-directed RNA polymerases I, II, and III subunit RPABC3 is a protein that in humans is encoded by the POLR2H gene.

This gene encodes one of the essential subunits of RNA polymerase II that is shared by the other two eukaryotic DNA-directed RNA polymerases, I and III.^[5]

Interactions

POLR2H has been shown to interact with POLR2C,^[6] POLR2G,^[6] POLR2A,^[6] POLR2B^[6] and POLR2E.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163882 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021018 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: POLR2H polymerase (RNA) II (DNA directed) polypeptide H".
^ ^a ^b ^c ^d ^e Acker J, de Graaff M, Cheynel I, Khazak V, Kedinger C, Vigneron M (July 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. 272 (27). UNITED STATES: 16815–21. doi:10.1074/jbc.272.27.16815. ISSN 0021-9258. PMID 9201987.

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Romano G, Kasten M, De Falco G, et al. (2000). "Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression". J. Cell. Biochem. 75 (3): 357–68. doi:10.1002/(SICI)1097-4644(19991201)75:3<357::AID-JCB1>3.0.CO;2-K. PMID 10536359. S2CID 43685090.
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Southgate C, Zapp ML, Green MR (1990). "Activation of transcription by HIV-1 Tat protein tethered to nascent RNA through another protein". Nature. 345 (6276): 640–2. Bibcode:1990Natur.345..640S. doi:10.1038/345640a0. PMID 2190099. S2CID 4233742.
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