Protein-coding gene in the species Homo sapiens
SLC38A10 |
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Identifiers |
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Aliases | SLC38A10, PP1744, solute carrier family 38 member 10 |
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External IDs | OMIM: 616525; MGI: 1919305; HomoloGene: 41556; GeneCards: SLC38A10; OMA:SLC38A10 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 17 (human)[1] |
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| Band | 17q25.3 | Start | 81,244,811 bp[1] |
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End | 81,295,547 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 11 (mouse)[2] |
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| Band | 11|11 E2 | Start | 119,994,786 bp[2] |
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End | 120,042,172 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - anterior pituitary
- body of pancreas
- right lobe of liver
- right lobe of thyroid gland
- mucosa of transverse colon
- apex of heart
- right uterine tube
- right coronary artery
- left lobe of thyroid gland
- granulocyte
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| Top expressed in | - motor neuron
- fossa
- calvaria
- aortic valve
- ascending aorta
- vestibular membrane of cochlear duct
- Paneth cell
- condyle
- external carotid artery
- iris
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - amino acid transmembrane transporter activity
| Cellular component | - integral component of membrane
- membrane
- Golgi apparatus
| Biological process | - amino acid transmembrane transport
- bone development
- ion transport
- amino acid transport
- sodium ion transport
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | NM_001164798 NM_001164799 NM_001164800 NM_001164801 NM_001164802
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NM_024249 NM_001361696 NM_001361697 NM_001361698 NM_001361699 |
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RefSeq (protein) | | NP_001158270 NP_001158271 NP_001158272 NP_001158273 NP_001158274
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NP_077211 NP_001348625 NP_001348626 NP_001348627 NP_001348628 |
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Location (UCSC) | Chr 17: 81.24 – 81.3 Mb | Chr 11: 119.99 – 120.04 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Putative sodium-coupled neutral amino acid transporter 10, also known as solute carrier family 38 member 10,[5] is a protein that in humans is encoded by the SLC38A10 gene.[6]
Cellular localization
Cellular localization study of SLC38A10 protein was investigated on different cell lines and primary cortex neuronal cells using Immunocytochemistry and GFP SLC38A10 vector. SLC38A10 localized on Golgi apparatus and ER organelles.[7]
Recent study on SLC38A10 knockout model provided some insight on possible association with p53 protein and cell survival.[8]
Cancer
A SLC38A family member has been observed progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.[9] For this reason, SLC38A is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.[9]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000157637 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061306 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "SLC38A10 - Function". www.nextprot.org. Retrieved 2021-11-29.
- ^ "Entrez Gene: solute carrier family 38, member 10". Retrieved 2011-08-30.
- ^ Tripathi R, Hosseini K, Arapi V, Fredriksson R, Bagchi S (December 2019). "SLC38A10 (SNAT10) is Located in ER and Golgi Compartments and Has a Role in Regulating Nascent Protein Synthesis". International Journal of Molecular Sciences. 20 (24): 6265. doi:10.3390/ijms20246265. PMC 6940841. PMID 31842320.
- ^ Tripathi R, Aggarwal T, Fredriksson R (2021). "SLC38A10 Transporter Plays a Role in Cell Survival Under Oxidative Stress and Glutamate Toxicity". Frontiers in Molecular Biosciences. 8: 671865. doi:10.3389/fmolb.2021.671865. ISSN 2296-889X. PMC 8133219. PMID 34026845.
- ^ a b Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, et al. (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". Journal of Cellular Physiology. 230 (4): 806–12. doi:10.1002/jcp.24808. hdl:11392/2066612. PMID 25205602. S2CID 24986454.
Further reading
- Yashin AI, Wu D, Arbeev KG, Ukraintseva SV (September 2010). "Joint influence of small-effect genetic variants on human longevity". Aging. 2 (9): 612–20. doi:10.18632/aging.100191. PMC 2984609. PMID 20834067.
Membrane proteins, carrier proteins: membrane transport proteins solute carrier (TC 2A)
By group |
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SLC1–10 |
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(1): | - high affinity glutamate and neutral amino-acid transporter
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(2): | |
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(3): | |
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(4): | |
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(5): | |
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(6): | |
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(7): | |
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(8): | |
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(9): | |
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(10): | |
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| SLC11–20 |
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(11): | - proton coupled metal ion transporter
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(12): | |
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(13): | - human Na+-sulfate/carboxylate cotransporter
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(14): | |
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(15): | - proton oligopeptide cotransporter
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(16): | - monocarboxylate transporter
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(17): | |
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(18): | |
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(19): | |
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(20): | - type III Na+-phosphate cotransporter
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| SLC21–30 |
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(21): | |
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(22): | |
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(23): | - Na+-dependent ascorbic acid transporter
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(24): | |
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(25): | |
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(26): | - multifunctional anion exchanger
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(27): | |
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(28): | - Na+-coupled nucleoside transport (SLC28A1
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(29): | - facilitative nucleoside transporter
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(30): | |
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| SLC31–40 |
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(31): | |
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(32): | |
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(33): | |
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(34): | - type II Na+-phosphate cotransporter
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(35): | - nucleoside-sugar transporter
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-
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- SLC35E1
- SLC35E2
- SLC35E3
- SLC35E4
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(36): | |
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(37): | - sugar-phosphate/phosphate exchanger
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(38): | - System A & N, sodium-coupled neutral amino-acid transporter
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(39): | |
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(40): | - basolateral iron transporter
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| SLC41–48 |
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(41): | |
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(42): | |
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(43): | - Na+-independent, system-L like amino-acid transporter
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(44): | |
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(45): | - Putative sugar transporter
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(46): | |
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(47): | |
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(48): | |
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see also solute carrier disorders |
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