8-OH-DPAT
Nazivi | |
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IUPAC naziv 8-Hidroksi-2-(di-n-propilamino)tetralin | |
Sistemski IUPAC naziv 7-(Dipropilamino)-5,6,7,8-tetrahidronaftalen-1-ol[1] | |
Identifikacija | |
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3D model (Jmol) |
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Abrevijacija | 8-OH-DPAT |
ChemSpider |
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IUPHAR/BPS |
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MeSH | 8-Hydroxy-2-(di-N-propylamino)tetralin |
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SMILES
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Svojstva | |
C16H25NO | |
Molarna masa | 247,38 g·mol−1 |
log P | 3,711 |
Kiselost (pKa) | 10,539 |
Baznost (pKb) | 3,458 |
Farmakologija | |
Farmakokinetika: | |
Poluvreme eliminacije | 1,5 sata |
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa). | |
Y verifikuj (šta je YН ?) | |
Reference infokutije | |
8-OH-DPAT je istraživačka hemikalija iz aminotetralinske hemijske klase koja je razvijena tokom 1980-tih i široko korišćena u ispitivanju funkcije 5-HT1A receptora. On je bio jedan od prvih agonista) 5-HT1A receptora.
Originalno se verovalo da je selektivan za 5-HT1A receptor. Kasnije je utvrđeno da 8-OH-DPAT takođe deluje kao agonist 5-HT7 receptora i kao inhibitor serotoninskog preuzimanja/agens serotoninskog otpuštanja.[4][5][6][7][8]
Reference
- ^ „8-hydroxy-2-(di-N-propylamino)tetralin - PubChem Public Chemical Database”. The PubChem Project. USA: National Center for Biotechnology Information.
- ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
- ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
- ^ Larsson LG, Rényi L, Ross SB, Svensson B, Angeby-Möller K (1990). „Different effects on the responses of functional pre- and postsynaptic 5-HT1A receptors by repeated treatment of rats with the 5-HT1A receptor agonist 8-OH-DPAT”. Neuropharmacology. 29 (2): 85—91. PMID 1691832. doi:10.1016/0028-3908(90)90047-U.
- ^ Sprouse J, Reynolds L, Li X, Braselton J, Schmidt A (2004). „8-OH-DPAT as a 5-HT7 agonist: phase shifts of the circadian biological clock through increases in cAMP production”. Neuropharmacology. 46 (1): 52—62. PMID 14654097. doi:10.1016/j.neuropharm.2003.08.007.
- ^ „IUPHAR DATABASE - 5-Hydroxytryptamine receptors - 5-HT7”. Архивирано из оригинала 03. 03. 2016. г. Приступљено 05. 10. 2012.
- ^ Assié MB, Koek W (1996). „Possible in vivo 5-HT reuptake blocking properties of 8-OH-DPAT assessed by measuring hippocampal extracellular 5-HT using microdialysis in rats”. British Journal of Pharmacology. 119 (5): 845—50. PMC 1915946 . PMID 8922730.
- ^ Wölfel R, Graefe KH (1992). „Evidence for various tryptamines and related compounds acting as substrates of the platelet 5-hydroxytryptamine transporter”. Naunyn-Schmiedeberg's Archives of Pharmacology. 345 (2): 129—36. PMID 1570019. doi:10.1007/BF00165727.
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Antagonisti i/ili inhibitori | |||||||||
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Triciklični i tetraciklični antidepresivi (TCA/TeCA) | |||||
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Inhibitori monoamin oksidaze (MAOI) | |||||||
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