ADAM18

Protein-coding gene in the species Homo sapiens
ADAM18
Identifiers
AliasesADAM18, ADAM27, tMDCIII, ADAM metallopeptidase domain 18
External IDsMGI: 105986; HomoloGene: 74941; GeneCards: ADAM18; OMA:ADAM18 - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for ADAM18
Genomic location for ADAM18
Band8p11.22Start39,584,489 bp[1]
End39,730,065 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for ADAM18
Genomic location for ADAM18
Band8|8 A2Start25,092,262 bp[2]
End25,164,771 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • left testis

  • right testis

  • testicle

  • gonad

  • monocyte

  • right coronary artery

  • apex of heart

  • left ventricle

  • urinary bladder
Top expressed in
  • spermatocyte

  • spermatid

  • seminiferous tubule

  • visual cortex

  • primary visual cortex

  • superior frontal gyrus

  • islet of Langerhans

  • somite
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • metalloendopeptidase activity
  • metallopeptidase activity
Cellular component
  • integral component of membrane
  • membrane
Biological process
  • multicellular organism development
  • cell differentiation
  • spermatogenesis
  • proteolysis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8749

13524

Ensembl

ENSG00000168619
ENSG00000278548

ENSMUSG00000031552

UniProt

Q9Y3Q7

Q9R157

RefSeq (mRNA)

NM_001190956
NM_014237
NM_001320313

NM_010084

RefSeq (protein)

NP_001177885
NP_001307242
NP_055052

NP_034214

Location (UCSC)Chr 8: 39.58 – 39.73 MbChr 8: 25.09 – 25.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Disintegrin and metalloproteinase domain-containing protein 18 is an enzyme that in humans is encoded by the ADAM18 gene.[5][6]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a sperm surface protein.[6]

References

  1. ^ a b c ENSG00000278548 GRCh38: Ensembl release 89: ENSG00000168619, ENSG00000278548 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031552 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Frayne J, Hurd EA, Hall L (Aug 2002). "Human tMDC III: a sperm protein with a potential role in oocyte recognition". Mol Hum Reprod. 8 (9): 817–22. doi:10.1093/molehr/8.9.817. PMID 12200459.
  6. ^ a b "Entrez Gene: ADAM18 ADAM metallopeptidase domain 18".

Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Zhu GZ, Lin Y, Myles DG, Primakoff P (1999). "Identification of four novel ADAMs with potential roles in spermatogenesis and fertilization". Gene. 234 (2): 227–37. doi:10.1016/S0378-1119(99)00208-5. PMID 10395895.
  • Frayne J, Jury JA, Barker HL, et al. (1998). "Macaque MDC family of proteins: sequence analysis, tissue distribution and processing in the male reproductive tract". Mol. Hum. Reprod. 4 (5): 429–37. doi:10.1093/molehr/4.5.429. PMID 9665629.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

External links

  • The MEROPS online database for peptidases and their inhibitors: M12.957
  • Human ADAM18 genome location and ADAM18 gene details page in the UCSC Genome Browser.
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