Ajmalicin
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(IUPAC) ime | |||
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metil estar (19α)-16,17-didehidro- 19-metiloksajohimban- 16-karboksilne kiseline | |||
Klinički podaci | |||
Identifikatori | |||
CAS broj | 483-04-5 | ||
ATC kod | nije dodeljen | ||
PubChem[1][2] | 251561 | ||
ChemSpider[3] | 390541 | ||
ChEMBL[4] | CHEMBL123325 ![]() | ||
Hemijski podaci | |||
Formula | C21H24N2O3 | ||
Mol. masa | 352,43 g/mol | ||
SMILES | eMolekuli & PubHem | ||
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Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status | ℞ Prescription only | ||
Način primene | Oralno |
Ajmalicin (δ-johimbin, raubazin) je antihipertenziv koji se koristi kao tretman za visoki krvni pritisak.[5] On je bio u prodaji pod raznim imenima, neka od kojih su: Card-Lamuran, Circolene, Cristanyl, Duxil, Duxor, Hydroxysarpon, Iskedyl, Isosarpan, Isquebral, Lamuran, Melanex, Saltucin Co, Salvalion, i Sarpan.[5] On je isto tako alkaloid koji je prirodno javlja u raznim biljkama kao što su Rauwolfia spp., Catharanthus roseus, i Mitragyna speciosa.[5][6][7]
Ajmalicin je strukturno srodan sa johimbinom, rauvolscinom, i drugim johimbanskim derivatima. Poput korinantina, on deluje kao antagonist α1-adrenergičkog receptora. On je znatno manje aktivan na α2-adrenergičkim receptorima, iz čega proizilazi njegovo hipotenzivno dejstvo.[5][8]
Reference
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ 5,0 5,1 5,2 5,3 Wink, Michael; Roberts, M. W. (1998). Alkaloids: biochemistry, ecology, and medicinal applications. New York: Plenum Press. ISBN 0-306-45465-3.
- ↑ Kurz WG, Chatson KB, Constabel F, et al. (May 1981). „Alkaloid Production in Catharanthus roseus Cell Cultures VIII1”. Planta Medica 42 (5): 22–31. DOI:10.1055/s-2007-971541. PMID 17401876.
- ↑ León F, Habib E, Adkins JE, Furr EB, McCurdy CR, Cutler SJ (July 2009). „Phytochemical characterization of the leaves of Mitragyna speciosa grown in U.S.A”. Natural Product Communications 4 (7): 907–10. PMID 19731590.
- ↑ Roquebert J, Demichel P (October 1984). „Inhibition of the alpha 1 and alpha 2-adrenoceptor-mediated pressor response in pithed rats by raubasine, tetrahydroalstonine and akuammigine”. European Journal of Pharmacology 106 (1): 203–5. DOI:10.1016/0014-2999(84)90698-8. PMID 6099269.
Povezano
- p
- r
- u
(antagoniziraju α-adrenergičku
vazokonstrikciju)
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