Nervonska kiselina
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Nazivi | |
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IUPAC naziv (Z)-Tetrakoz-15-enoinska kiselina | |
Drugi nazivi cis-15-Tetrakozenoinska kiselina 24:1 cis, delta 9 ili 24:1 omega 9 | |
Identifikacija | |
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3D model (Jmol) |
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ChEBI |
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ChemSpider |
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ECHA InfoCard | 100.108.655 |
KEGG[2] |
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PubChem[3][4] C ID |
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SMILES
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Svojstva | |
C24H46O2 | |
Molarna masa | 366,62 g/mol |
Tačka topljenja | 42–43 °C |
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa). | |
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Reference infokutije | |
Nervonska kiselina je mononezasićena omega-9 masna kiselina. Utvrđeno je da je nervonska kiselina važna u biosintezi mijelina nervnih ćelija.[5] Ona je prisutana u sfingolipidima bele materije ljudskog mozga.
Nervonska kiselina se koristi u tretmanu poremećaja uzrokovanih demijelinacijom, kao što su adrenoleukodistrofija i multipla skleroza gde postoji snižen nivo nervonske kiseline u sfingolipidima.[6]
Reference
- ^ Nervonic acid at Sigma-Aldrich
- ^ Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
- ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
- ^ US Patent 6664406[мртва веза], Nervonic acid derivatives, their preparation and use
- ^ WO/1996/005740[мртва веза], Nervonic Acid Compositions
Literatura
- Appelqvist (1976) Lipids in Cruciferae. In: Vaughan JG, Macleod AJ (Eds), The biology and the Chemistry of Cruciferae. Academic Press, London, UK, pp. 221–277.
- Sargent JR, Coupland K, Wilson R (1994). Nervonic Acid and Demyelinating Disease. Medical Hypothesese 42, pp. 237–242.
Spoljašnje veze
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Volatilne: Sirćetna (C2) · Propionska (C3) · Buterna (C4) · Valerinska (C5) · Kapronska (C6) · Enantinska (C7) · Kaprilna (C8) · Pelargonska (C9) · Kaprinska (C10) · Undekanska (C11) · Laurinska (C12) · Tridekanska (C13) · Miristinska (C14) · Pentadekanska (C15) · Palmitinska (C16) · Margarinska (C17) · Stearinska (C18) · Nonadekanska (C19) · Arahidinska (C20) · Behenska (C22) · Lignocerinska (C24) · Kerotinska (C26) · Montanska (C28)
Oleinska (18:1) • Elaidinska (trans-18:1) • Eikozenoinska (20:1) • Erukinska (22:1) • Nervonska (24:1) • Mead (20:3)